基本信息

产品名称	Transferrin Receptor/CD71 Rat mAb (Biotin)
别名	转铁蛋白受体(TFR)抗体 \| Transferrin Receptor/CD71抗体
英文别名	TFR \| Trfr \| Mtvr1 \| 2610028K12Rik \| E430033M20Rik \| CD71 antigen \| CD71 \| CD71TRFR \| p90 \| T9 \| TfR (Transferrin R) \| TfR (TransferrinR) \| TFR1 \| TFRC \| TR \| transferrin receptor (p90, CD71) \| transferrin receptor protein 1 \| CD 71 antibody \| CD71 antibo
规格或纯度	ExactAb™, 已验证, 0.5 mg/mL
生化机理	Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
宿主种属	大鼠(Rat)
特异性	Transferrin Receptor/CD71
种属反应性	小鼠(Mouse)
免疫原	Mouse erythroleukemia cell line 745.6
阳性对照	Flow: C57BL/6 mouse bone marrow cells
偶联	Biotin

产品属性

克隆类型	单克隆抗体
Format	Whole IgG
轻链亚型	kappa
纯化方法	Protein G purified
储存缓冲液	Liquid in PBS pH 7.4, containing 1% BSA and 0.05% Proclin300.
防腐剂	0.05% Proclin300
浓度	0.5 mg/mL
储存温度	2-8°C储存,避光,禁止冻结
运输条件	冰袋运输
稳定性与储存	The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
分子类型	抗体

图片

Flow Cytometry: Transferrin Receptor/CD71 Rat mAb (Biotin) (Ab190201)

Transferrin Receptor/CD71 Rat mAb (Biotin) (Ab190201) - Flow Cytometry
Flow cytometry analysis of Transferrin Receptor/CD71 expression by C57BL/6 mouse bone marrow cells (right panel) compared to an isotype control (left panel). Cells were stained with Transferrin Receptor/CD71 Rat mAb (Biotin) (Ab190201) at 0.05μg/test for 1 hour at 4°C. Then incubated with Recombinant Streptavidin Protein (R-PE) (rp156150) at 0.1μg/test for 30 minutes at 4°C in the dark. Left panel - Rat IgG (Biotin) (Ab180310).

Flow Cytometry: Transferrin Receptor/CD71 Rat mAb (Biotin) (Ab190201)

Transferrin Receptor/CD71 Rat mAb (Biotin) (Ab190201) - Flow Cytometry
Flow cytometry analysis of Transferrin Receptor/CD71 expression by C57BL/6 mouse bone marrow cells (red) compared to an isotype control (blue). Cells were stained with Transferrin Receptor/CD71 Rat mAb (Biotin) (Ab190201) at 0.05μg/test for 1 hour at 4°C. Then incubated with Recombinant Streptavidin Protein (R-PE) (rp156150) at 0.1μg/test for 30 minutes at 4°C in the dark. Blue - Rat IgG (Biotin) (Ab180310). Black - Unlabelled control, cells without incubation with primary antibody.