基本信息

产品名称	Transferrin Receptor/CD71 Rat mAb (APC)
别名	转铁蛋白受体(TFR)抗体 \| Transferrin Receptor/CD71抗体
英文别名	TFR \| Trfr \| Mtvr1 \| 2610028K12Rik \| E430033M20Rik \| CD71 antigen \| CD71 \| CD71TRFR \| p90 \| T9 \| TfR (Transferrin R) \| TfR (TransferrinR) \| TFR1 \| TFRC \| TR \| transferrin receptor (p90, CD71) \| transferrin receptor protein 1 \| CD 71 antibody \| CD71 antibo
规格或纯度	ExactAb™, 已验证, Ex:650nm, Em:660nm, 0.5 mg/mL
生化机理	Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
宿主种属	大鼠(Rat)
特异性	Transferrin Receptor/CD71
种属反应性	小鼠(Mouse)
免疫原	Mouse erythroleukemia cell line 745.6
阳性对照	Flow: C57BL/6 mouse bone marrow cells
偶联	APC
Excitation(nm)	Red Laser(633nm)
Emission(nm)	660nm
Ex/Em(nm)	Ex:650nm;Em:660nm

产品属性

克隆类型	单克隆抗体
Format	Whole IgG
轻链亚型	kappa
纯化方法	Protein G purified
储存缓冲液	Liquid in PBS pH 7.4, containing 1% BSA and 0.05% Proclin300.
防腐剂	0.05% Proclin300
浓度	0.5 mg/mL
储存温度	2-8°C储存,避光,禁止冻结
运输条件	冰袋运输
稳定性与储存	The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
分子类型	抗体

图片

Flow Cytometry: Transferrin Receptor/CD71 Rat mAb (APC) (Ab190204)

Transferrin Receptor/CD71 Rat mAb (APC) (Ab190204) - Flow Cytometry
Flow cytometry analysis of Transferrin Receptor/CD71 expression by C57BL/6 mouse bone marrow cells (right panel) compared to an isotype control (left panel). Cells were stained with Transferrin Receptor/CD71 Rat mAb (APC) (Ab190204) at 0.1μg/test for 1 hour at 4°C. Left panel - Rat IgG (APC) (Ab180313).

Flow Cytometry: Transferrin Receptor/CD71 Rat mAb (APC) (Ab190204)

Transferrin Receptor/CD71 Rat mAb (APC) (Ab190204) - Flow Cytometry
Flow cytometry analysis of Transferrin Receptor/CD71 expression by C57BL/6 mouse bone marrow cells (red) compared to an isotype control (blue). Cells were stained with Transferrin Receptor/CD71 Rat mAb (APC) (Ab190204) at 0.1μg/test for 1 hour at 4°C. Blue - Rat IgG (APC) (Ab180313). Black - Unlabelled control, cells without incubation with primary antibody.

关联靶点（人）

TFRC Tclin 转铁蛋白受体蛋白1(Transferrin receptor protein 1) (0 活性数据)

点击查看靶蛋白信息： TFRC

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

TFRC Tclin Transferrin receptor protein 1 (0 活性数据)

点击查看靶蛋白信息： TFRC

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

安全和危险性（GHS）

SDS英文版

质量标准

质量标准

应用

应用名称	稀释比例
Flow Cytometry	≤0.3μg/test For flow cytometric staining, the suggested use of this reagent is ≤0.3 μg per million cells in 100 µL staining volume.