| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| L140135-5ml |
5ml |
现货  |
| |
| L140135-8×5ml |
8×5ml |
现货 |
|
| 产品名称 | 青霉素酶液体 |
|---|---|
| 别名 | 青霉素酶 |
| 英文别名 | (6R,7R)-3-[(3-carboxy-4-nitrophenyl)sulfanylmethyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | CENTA | CENTA(TM) BETA-LACTAMASE SUBSTRATE | (6r,7r)-3-[(3-carboxy-4-nitrophenyl)sulfanylmethyl]-8-oxo-7-[(2-thiop |
| 规格或纯度 | EnzymoPure™, ＞300万单位/1ml |
| 生化机理 | β 内酰胺酶通过打开 β 内酰胺环使 β 内酰胺抗生素失活1。其他底物的典型分析：头孢曲松 2-4 单位/毫克；头孢唑啉 2-4 单位/毫克；头孢唑肟 1.5-3 单位/毫克；头孢西丁 0.35-0.7 单位/毫克；头孢吡肟 1.2-2.4 单位/毫克；头孢呋辛 1.5-3 单位/毫克；头孢他啶 1-2 单位/毫克；氧西林 4-8 单位/毫克；亚胺培南 1.2-2.4 单位/毫克；美罗培南 3-6 单位/毫克。 |
| 产品介绍 |
可水解β-内酰胺类抗生素。已发现二百多种β-内酰胺酶。青霉素酶的分类方法主要有两种，分子生物学方法和BUSH法。分子生物学法将酶分为四类。A类酶包括多种质粒编码的青霉素酶，活性部位为丝氨酸残基，分子量为29kDa。B类酶为金属酶，由染色体或质粒编码，酶活性需锌离子参与，可被乙二胺四乙酸（EDTA）抑制。C类酶的活性部位为丝氨酸残基，分子量为39kDa，其产生与诱导剂有关。C类酶主要指染色体编码的头孢菌素酶（AmpC酶）。D类酶又称为OXA型（水解苯唑西林）β-内酰胺酶。另一种分类方法为BUSH应用于环境中残留青霉素的清除；医疗器械残留青霉素的清以及青霉素效价测定中本底的清除； 用基因重组技术在大肠杆菌表达体系生产β-内酰胺酶（序列来自大肠杆菌），属于分子生物学分类A类，BUSH分类第二类的青霉素酶，学名为TEM1，目前有天然酶和融合酶两种形式提供。 Penicillinase from Bacillus cereus has been shown to contain three distinct species when purified and examined for homogeneity by sedimentation analysis, amino-terminal analysis, and vertical acrylamide gel electrophoresis. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 浓度 | ＞300万单位/1ml |
|---|---|
| 储存温度 | 2-8°C储存,充氩 |
| 运输条件 | 冰袋运输 |
| CAS编号和信息 | 9073-60-3 |
| 酶学委员会编号 | 3.5.2.6 |
| 单位定义 | PH7.0,37℃条件下，每小时分解青霉素钠活性单位的量。 |
| 分子类型 | 小分子 |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|
| Enzymatic Activity | ≥3000000（IU/ml OR u/ml） |
|---|---|
| Appearance（L140135) | Colorless to light yellow liquid |
¥83.32
| 1. Maohu Chen, Bo Qiu, Zhanlin Zhang, Shuang Xie, Yuan Liu, Tian Xia, Xiaohong Li. (2021) Light-triggerable and pH/lipase-responsive release of antibiotics and β-lactamase inhibitors from host-guest self-assembled micelles to combat biofilms and resistant bacteria. CHEMICAL ENGINEERING JOURNAL, 424 (130330). [10.1016/j.cej.2021.130330] |
| 2. Wenyao Chen, Shan Shan, Juan Peng, Daofeng Liu, Jun Xia, Bing Shao, Weihua Lai. (2020) Sensitive and hook effect–free lateral flow assay integrated with cascade signal transduction system. SENSORS AND ACTUATORS B-CHEMICAL, 321 (128465). [10.1016/j.snb.2020.128465] |
| 3. Shan Shan, Daofeng Liu, Qi Guo, Songsong Wu, Rui Chen, Kai Luo, Liming Hu, Yonghua Xiong, Weihua Lai. (2016) Sensitive detection of Escherichia coli O157:H7 based on cascade signal amplification in ELISA. JOURNAL OF DAIRY SCIENCE, 99 (7025). [PMID:27394946] [10.3168/jds.2016-11320] |
| 4. Chen Chen, Jun Lv, Wanyi Chen, Yang Xiang, Juan Zhang. (2016) Colorimetric β-lactamase inhibitor assay with double catalyzed signal amplification. NEW JOURNAL OF CHEMISTRY, 40 (3): (1982-1987). [10.1039/C5NJ02356D] |
| 5. Lihong Li, Zhao Li, Wen Shi, Xiaohua Li, Huimin Ma. (2014) Sensitive and Selective Near-Infrared Fluorescent Off–On Probe and Its Application to Imaging Different Levels of β-Lactamase in Staphylococcus aureus. ANALYTICAL CHEMISTRY, 86 (12): (6115–6120). [PMID:24844761] [10.1021/ac501288e] |
| 1. Maohu Chen, Bo Qiu, Zhanlin Zhang, Shuang Xie, Yuan Liu, Tian Xia, Xiaohong Li. (2021) Light-triggerable and pH/lipase-responsive release of antibiotics and β-lactamase inhibitors from host-guest self-assembled micelles to combat biofilms and resistant bacteria. CHEMICAL ENGINEERING JOURNAL, 424 (130330). [10.1016/j.cej.2021.130330] |
| 2. Wenyao Chen, Shan Shan, Juan Peng, Daofeng Liu, Jun Xia, Bing Shao, Weihua Lai. (2020) Sensitive and hook effect–free lateral flow assay integrated with cascade signal transduction system. SENSORS AND ACTUATORS B-CHEMICAL, 321 (128465). [10.1016/j.snb.2020.128465] |
| 3. Shan Shan, Daofeng Liu, Qi Guo, Songsong Wu, Rui Chen, Kai Luo, Liming Hu, Yonghua Xiong, Weihua Lai. (2016) Sensitive detection of Escherichia coli O157:H7 based on cascade signal amplification in ELISA. JOURNAL OF DAIRY SCIENCE, 99 (7025). [PMID:27394946] [10.3168/jds.2016-11320] |
| 4. Chen Chen, Jun Lv, Wanyi Chen, Yang Xiang, Juan Zhang. (2016) Colorimetric β-lactamase inhibitor assay with double catalyzed signal amplification. NEW JOURNAL OF CHEMISTRY, 40 (3): (1982-1987). [10.1039/C5NJ02356D] |
| 5. Lihong Li, Zhao Li, Wen Shi, Xiaohua Li, Huimin Ma. (2014) Sensitive and Selective Near-Infrared Fluorescent Off–On Probe and Its Application to Imaging Different Levels of β-Lactamase in Staphylococcus aureus. ANALYTICAL CHEMISTRY, 86 (12): (6115–6120). [PMID:24844761] [10.1021/ac501288e] |
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