PI3K/Akt/mTOR 信号通路 - 按“信号通路”分类 - 小分子和化合物库

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OSU-03012 (AR-12),PDPK1（PDK1）抑制剂
- ≥98%
CAS号 : 742112-33-0 Compound CID : 10027278

分子式: C₂₆H₁₉F₃N₄O 分子量: 460.46

IUPAC Name: 2-amino-N-[4-[5-phenanthren-2-yl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]acetamide

SMILES: C1=CC=C2C(=C1)C=CC3=C2C=CC(=C3)C4=CC(=NN4C5=CC=C(C=C5)NC(=O)CN)C(F)(F)F

InChIKey: YULUCECVQOCQFQ-UHFFFAOYSA-N

InChI: InChI=1S/C26H19F3N4O/c27-26(28,29)24-14-23(33(32-24)20-10-8-19(9-11-20)31-25(34)15-30)18-7-12-22-17(13-18)6-5-16-3-1-2-4-21(16)22/h1-14H,15,30H2,(H,31,34)
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PHT-427,双Akt和PDK1抑制剂
- ≥98%
CAS号 : 1191951-57-1 Compound CID : 44240850

分子式: C₂₀H₃₁N₃O₂S₂ 分子量: 409.61

IUPAC Name: 4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

SMILES: CCCCCCCCCCCCC1=CC=C(C=C1)S(=O)(=O)NC2=NN=CS2

InChIKey: BYWWNRBKPCPJMG-UHFFFAOYSA-N

InChI: InChI=1S/C20H31N3O2S2/c1-2-3-4-5-6-7-8-9-10-11-12-18-13-15-19(16-14-18)27(24,25)23-20-22-21-17-26-20/h13-17H,2-12H2,1H3,(H,22,23)
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BX-912,PDK1 抑制剂
- ≥97%
CAS号 : 702674-56-4 Compound CID : 11754511

分子式: C₂₀H₂₃BrN₈O 分子量: 471.36

IUPAC Name: N-[3-[[5-bromo-4-[2-(1H-imidazol-5-yl)ethylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide

SMILES: C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCC4=CN=CN4)Br

InChIKey: DMMILYKXNCVKOJ-UHFFFAOYSA-N

InChI: InChI=1S/C20H23BrN8O/c21-17-12-24-19(28-18(17)23-7-6-16-11-22-13-25-16)26-14-4-3-5-15(10-14)27-20(30)29-8-1-2-9-29/h3-5,10-13H,1-2,6-9H2,(H,22,25)(H,27,30)(H2,23,24,26,28)
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BX-795,PDK1抑制剂
- ≥97%
CAS号 : 702675-74-9 Compound CID : 10077147

分子式: C₂₃H₂₆IN₇O₂S 分子量: 591.47

IUPAC Name: N-[3-[[5-iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide

SMILES: C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I

InChIKey: VAVXGGRQQJZYBL-UHFFFAOYSA-N

InChI: InChI=1S/C23H26IN7O2S/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31/h3-4,6-8,13-15H,1-2,5,9-12H2,(H,26,32)(H,29,33)(H2,25,27,28,30)
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GSK2334470,新型有效的PDK1抑制剂
- ≥95%
CAS号 : 1227911-45-6 Compound CID : 46215815

分子式: C₂₅H₃₄N₈O 分子量: 462.59

IUPAC Name: (3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N-cyclohexyl-6-methylpiperidine-3-carboxamide

SMILES: CC1CCC(CN1C2=NC(=NC(=C2)C3=CC4=C(C=C3)C(=NN4)N)NC)C(=O)NC5CCCCC5

InChIKey: QLPHOXTXAKOFMU-WBVHZDCISA-N

InChI: InChI=1S/C25H34N8O/c1-15-8-9-17(24(34)28-18-6-4-3-5-7-18)14-33(15)22-13-20(29-25(27-2)30-22)16-10-11-19-21(12-16)31-32-23(19)26/h10-13,15,17-18H,3-9,14H2,1-2H3,(H,28,34)(H3,26,31,32)(H,27,29,30)/t15-,17+/m1/s1
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BX517
- ≥98%
CAS号 : 850717-64-5 Compound CID : 11161844

分子式: C₁₅H₁₄N₄O₂ 分子量: 282.30

IUPAC Name: [(3Z)-2-oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]-1H-indol-5-yl]urea

SMILES: CC(=C1C2=C(C=CC(=C2)NC(=O)N)NC1=O)C3=CC=CN3

InChIKey: DFURSNCTQGJRRX-JYRVWZFOSA-N

InChI: InChI=1S/C15H14N4O2/c1-8(11-3-2-6-17-11)13-10-7-9(18-15(16)21)4-5-12(10)19-14(13)20/h2-7,17H,1H3,(H,19,20)(H3,16,18,21)/b13-8-
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