页面 5 | JAK/STAT 信号通路 - 按“信号通路”分类

TAK-285

规格或纯度 :

≥98%

CAS号: 871026-44-7 Compound CID : 11620908

分子式: C₂₆H₂₅ClF₃N₅O₃ 分子量: 547.96

IUPAC Name: N-[2-[4-[3-chloro-4-[3-(trifluoromethyl)phenoxy]anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethyl]-3-hydroxy-3-methylbutanamide

SMILES: CC(C)(CC(=O)NCCN1C=CC2=C1C(=NC=N2)NC3=CC(=C(C=C3)OC4=CC=CC(=C4)C(F)(F)F)Cl)O

InChIKey: ZYQXEVJIFYIBHZ-UHFFFAOYSA-N

InChI: 1S/C26H25ClF3N5O3/c1-25(2,37)14-22(36)31-9-11-35-10-8-20-23(35)24(33-15-32-20)34-17-6-7-21(19(27)13-17)38-18-5-3-4-16(12-18)26(28,29)30/h3-8,10,12-13,15,37H,9,11,14H2,1-2H3,(H,31,36)(H,32,33,34)

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酪氨酸磷酸化抑制剂A23

规格或纯度 :

≥98%

CAS号: 118409-57-7 Compound CID : 2052

分子式: C₁₀H₆N₂O₂ 分子量: 186.17

IUPAC Name: 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile

SMILES: C1=CC(=C(C=C1C=C(C#N)C#N)O)O

InChIKey: VTJXFTPMFYAJJU-UHFFFAOYSA-N

InChI: 1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H

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SMI-4a,ATP竞争性Pim激酶抑制剂

规格或纯度 :

≥98%

CAS号: 438190-29-5 Compound CID : 1361334

分子式: C₁₁H₆F₃NO₂S 分子量: 273.23

IUPAC Name: (5Z)-5-[[3-(trifluoromethyl)phenyl]methylidene]-1,3-thiazolidine-2,4-dione

SMILES: C1=CC(=CC(=C1)C(F)(F)F)C=C2C(=O)NC(=O)S2

InChIKey: NGJLOFCOEOHFKQ-YVMONPNESA-N

InChI: 1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5-

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Tyrphostin AG 879 酪氨酸激酶的抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 148741-30-4 Compound CID : 135419190

分子式: C₁₈H₂₄N₂OS 分子量: 316.46

IUPAC Name: (E)-2-cyano-3-(3,5-ditert-butyl-4-hydroxyphenyl)prop-2-enethioamide

SMILES: CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C(=S)N

InChIKey: XRZYELWZLNAXGE-KPKJPENVSA-N

InChI: 1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+

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三乙酰基白藜芦醇

规格或纯度 :

≥98%

CAS号: 42206-94-0 Compound CID : 5962587

分子式: C₂₀H₁₈O₆ 分子量: 354.35

IUPAC Name: [4-[(E)-2-(3,5-diacetyloxyphenyl)ethenyl]phenyl] acetate

SMILES: CC(=O)OC1=CC=C(C=C1)C=CC2=CC(=CC(=C2)OC(=O)C)OC(=O)C

InChIKey: PDAYUJSOJIMKIS-SNAWJCMRSA-N

InChI: 1S/C20H18O6/c1-13(21)24-18-8-6-16(7-9-18)4-5-17-10-19(25-14(2)22)12-20(11-17)26-15(3)23/h4-12H,1-3H3/b5-4+

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蔓荆子黄素

规格或纯度 :

分析标准品

≥98%(HPLC)

CAS号: 479-91-4

分子式: C₁₉H₁₈O₈ 分子量: 374.34

IUPAC Name: 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxychromen-4-one

SMILES: COC1=C(C=C(C=C1)C2=C(C(=O)C3=C(C(=C(C=C3O2)OC)OC)O)OC)O

InChIKey: PJQLSMYMOKWUJG-UHFFFAOYSA-N

InChI: 1S/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3

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WHI-P154,JAK3激酶抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 211555-04-3 Compound CID : 3795

分子式: C₁₆H₁₄BrN₃O₃ 分子量: 376.2

IUPAC Name: 2-bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)O)Br)OC

InChIKey: CBIAKDAYHRWZCU-UHFFFAOYSA-N

InChI: 1S/C16H14BrN3O3/c1-22-14-6-10-12(7-15(14)23-2)18-8-19-16(10)20-9-3-4-13(21)11(17)5-9/h3-8,21H,1-2H3,(H,18,19,20)

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WZ8040

规格或纯度 :

≥98%

CAS号: 1214265-57-2 Compound CID : 44607531

分子式: C₂₄H₂₅ClN₆OS 分子量: 481.02

IUPAC Name: N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]sulfanylphenyl]prop-2-enamide

SMILES: CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)SC4=CC=CC(=C4)NC(=O)C=C)Cl

InChIKey: KIISCIGBPUVZBF-UHFFFAOYSA-N

InChI: 1S/C24H25ClN6OS/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-24(29-23)28-17-7-9-19(10-8-17)31-13-11-30(2)12-14-31/h3-10,15-16H,1,11-14H2,2H3,(H,27,32)(H,26,28,29)

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WZ4002

规格或纯度 :

Moligand™

≥98%

CAS号: 1213269-23-8 Compound CID : 44607530

分子式: C₂₅H₂₇ClN₆O₃ 分子量: 494.97

IUPAC Name: N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

SMILES: CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl)OC

InChIKey: ITTRLTNMFYIYPA-UHFFFAOYSA-N

InChI: 1S/C25H27ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h4-9,14-16H,1,10-13H2,2-3H3,(H,28,33)(H,27,29,30)

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WZ3146

规格或纯度 :

≥98%

CAS号: 1214265-56-1 Compound CID : 44607360

分子式: C₂₄H₂₅ClN₆O₂ 分子量: 464.96

IUPAC Name: N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

SMILES: CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl

InChIKey: APHGZZPEOCCYNO-UHFFFAOYSA-N

InChI: 1S/C24H25ClN6O2/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-24(29-23)28-17-7-9-19(10-8-17)31-13-11-30(2)12-14-31/h3-10,15-16H,1,11-14H2,2H3,(H,27,32)(H,26,28,29)

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WP1066,JAK / STAT3抑制剂

规格或纯度 :

Moligand™

≥98%

CAS号: 857064-38-1 Compound CID : 11210478

分子式: C₁₇H₁₄BrN₃O 分子量: 356.22

IUPAC Name: (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide

SMILES: CC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N

InChIKey: VFUAJMPDXIRPKO-LQELWAHVSA-N

InChI: 1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1

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Varlitinib,小分子抑制剂

规格或纯度 :

Moligand™

≥96%

CAS号: 845272-21-1 Compound CID : 42642648

分子式: C₂₂H₁₉ClN₆O₂S 分子量: 466.94

IUPAC Name: 4-N-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-6-N-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine

SMILES: CC1COC(=N1)NC2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=NC=CS5)Cl

InChIKey: UWXSAYUXVSFDBQ-CYBMUJFWSA-N

InChI: 1S/C22H19ClN6O2S/c1-13-10-31-22(27-13)29-14-2-4-18-16(8-14)21(26-12-25-18)28-15-3-5-19(17(23)9-15)30-11-20-24-6-7-32-20/h2-9,12-13H,10-11H2,1H3,(H,27,29)(H,25,26,28)/t13-/m1/s1

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