| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab215383-10T |
10T |
期货  |
| |
| Ab215383-25T |
25T |
期货 |
| |
| Ab215383-100T |
100T |
期货 |
|
| 产品名称 | Recombinant CD98 Antibody (APC) |
|---|---|
| 别名 | CD98抗体 |
| 英文别名 | 4F2 antibody | 4F2 cell surface antigen heavy chain antibody | 4F2 cell-surface antigen heavy chain antibody | 4F2 heavy chain antibody | 4F2 heavy chain antigen antibody | 4F2_HUMAN antibody | 4F2hc antibody | 4T2HC antibody | Antigen defined by monoclon |
| 规格或纯度 | ExactAb™, 已验证, 5 μL/test |
| 生化机理 | Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier. Post-translational: Phosphorylation on Ser-406; Ser-408 or Ser-410 and on Ser-527 or Ser-531 by ecto-protein kinases favors heterotypic cell-cell interactions. |
| 宿主种属 | 人(Human) |
| 特异性 | SLC3A2 |
| 种属反应性 | 人(Human),食蟹猴(Cynomolgus monkey) |
| 阳性对照 | Flow Cytometry: MCF-7 |
| 偶联 | APC |
| Excitation(nm) | Red Laser(633nm) |
| Emission(nm) | 660nm |
| Ex/Em(nm) | Ex:650nm;Em:660nm |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 轻链亚型 | kappa |
| SDS-PAGE | 145.66 kDa |
| 纯化方法 | Protein A purified |
| 储存缓冲液 | Liquid in PBS pH 7.4, containing 1% BSA and 0.05% Proclin300. |
| 防腐剂 | 0.05% Proclin300 |
| 浓度 | 5 μL/test |
| 储存温度 | 2-8°C储存,避光,禁止冻结 |
| 运输条件 | 冰袋运输 |
| 稳定性与储存 | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| 分子类型 | 抗体 |
Recombinant CD98 Antibody (APC) (Ab215383) - Flow Cytometry
Flow cytometry analysis of CD98 expression by MCF-7 cells (red) compared to an isotype control (blue). Cells were stained with Recombinant CD98 Antibody (APC) (Ab215383) at 5μL/test for 1 hour at 4°C. Blue - Human IgG (APC) (Ab180317). Black - Unlabelled control, cells without incubation with primary antibody.
| 应用名称 | 稀释比例 |
|---|---|
| Flow Cytometry | 5μl/test For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. |
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