| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab175559-100μg |
100μg |
现货  |
| |
| Ab175559-1mg |
1mg |
现货 |
| |
| Ab175559-5mg |
5mg |
现货 |
| |
| Ab175559-10mg |
10mg |
期货 |
|
| 产品名称 | IGN523 (anti-CD98), 4F2hc 抗体 |
|---|---|
| 英文别名 | Ign523 | solute carrier family 3 (activators of dibasic and neutral amino acidtransport), member 2,4F2 heavy chain antigen | SLC3A2 | NACAE4F2 cell-surface antigen heavy chain | monoclonal 44D7 | MDU1antigen defined by monoclonal 4F2, heavy chain | Lympho |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 生化机理 | Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier. Post-translational: Phosphorylation on Ser-406; Ser-408 or Ser-410 and on Ser-527 or Ser-531 by ecto-protein kinases favors heterotypic cell-cell interactions. |
| 宿主种属 | 人(Human) |
| 特异性 | SLC3A2 |
| 种属反应性 | 人(Human),食蟹猴(Cynomolgus monkey) |
| 偶联 | Unconjugated |
| 作用类型 | 抗体 |
| 作用机制 | 4F2hc 抗体 |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | kappa |
| SDS-PAGE | 145.66 kDa |
| 纯化方法 | Protein A purified |
| 储存缓冲液 | Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| 分子类型 | 抗体 |
IGN523 (anti-CD98) (Ab175559) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD98 with IGN523 (anti-CD98) (Ab175559) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).
IGN523 (anti-CD98) (Ab175559) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD98 (red) with IGN523 (anti-CD98) (Ab175559) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.
IGN523 (anti-CD98) (Ab175559) - Flow Cytometry
Flow Cytometry analysis of HeLa cells labelling CD98 (red) with IGN523 (anti-CD98) (Ab175559) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
IGN523 (anti-CD98) (Ab175559) - Flow Cytometry
Flow Cytometry analysis of MCF7 cells labelling CD98 (red) with IGN523 (anti-CD98) (Ab175559) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
IGN523 (anti-CD98) (Ab175559) - Flow Cytometry
Flow Cytometry analysis of K562 cells labelling CD98 (red) with IGN523 (anti-CD98) (Ab175559) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
IGN523 (anti-CD98) (Ab175559) - ELISA
Immobilized Recombinant huSLC3A2-ECD-NHis protein at 2.0 μg/mL can bind IGN523 (anti-CD98) (Ab175559) with the EC₅₀ of 3.6 ng/mL.
IGN523 (anti-CD98) (Ab175559) - SEC
The purity of IGN523 (anti-CD98) (Ab175559) is more than 95% verified by HPLC.
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 ZJ24F1113362 |
分析证书 | 24-11-05 | Ab175559 |
| ZJ24F1113364 |
分析证书 | 24-11-05 | Ab175559 |
| ZJ24F1113363 |
分析证书 | 24-11-05 | Ab175559 |
¥1,099.90
¥699.90
¥1,099.90
| 1. Hayes GM, Chinn L, Cantor JM, Cairns B, Levashova Z, Tran H, Velilla T, Duey D, Lippincott J, Zachwieja J et al.. (2015) Antitumor activity of an anti-CD98 antibody.. Int J Cancer, 137 (3): (710-20). [PMID:25556716] |
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