基本信息

产品名称	Recombinant CD19 Antibody
别名	CD19抗体 \| CD19单抗
英文别名	B4 \| B-lymphocyte antigen CD19 \| B-lymphocyte surface antigen B4 \| CD19 antigen \| CD19 molecule \| CD19 \| CVID3 \| Differentiation antigen CD19 \| Leu-12 \| MGC12802 \| T-cell surface antigen Leu-12 \| Antibody deficiency due to defect in CD19 antibody \| Antibo
规格或纯度	无动物源, 无载体, 重组, ExactAb™, 无叠氮钠, 已验证, 高性能, ≥95%(SDS-PAGE), 见 COA
生化机理	Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes (PubMed:29523808). Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:1373518, PubMed:16672701, PubMed:2463100). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca2+ stores (PubMed:12387743, PubMed:16672701, PubMed:9317126, PubMed:9382888). Is not required for early steps during B cell differentiation in the blood marrow (PubMed:9317126). Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:1373518, PubMed:2463100). Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:12387743, PubMed:16672701, PubMed:9317126).
宿主种属	小鼠(Mouse)
特异性	CD19
种属反应性	人(Human)
免疫原	Intact normal human B cell cells
阳性对照	Flow Cytometry: Human peripheral blood monocyte
偶联	Unconjugated

产品属性

克隆类型	重组抗体
Format	Whole IgG
SDS-PAGE	150 kDa
纯化方法	Protein A purified
储存缓冲液	10mM PBS, pH 7.2-7.4
浓度	见 COA
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
分子类型	抗体

图片

Flow Cytometry: Recombinant CD19 Antibody (Ab210975)

Recombinant CD19 Antibody (Ab210975) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD19 with Recombinant CD19 Antibody (Ab210975) conjugated with biotin (right panel) at 1 μg/mL for 1 hour at 4°C, compared with Mouse IgG (Biotin) (Ab180306) - Isotype Control (left panel) and detected with SA-PE (rp156150).

Flow Cytometry: Recombinant CD19 Antibody (Ab210975)

Recombinant CD19 Antibody (Ab210975) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD19 (red) with Recombinant CD19 Antibody (Ab210975) conjugated with biotin at 1 μg/mL for 1 hour at 4°C, and detected with SA-PE (rp156150). Blue - Isotype control, compared with Mouse IgG (Biotin) (Ab180306). Black - Unlabelled control, cells without incubation with primary antibody.