Inebilizumab (anti-CD19), B 淋巴细胞抗原的结合剂 CD19 结合剂

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
功能和特点
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 小鼠(Mouse)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
Ab170867-100μg
100μg 现货 Stock Image
Ab170867-1mg
1mg 现货 Stock Image
Ab170867-5mg
5mg 现货 Stock Image
Ab170867-10mg
10mg 期货 Stock Image

基本信息

产品名称 Inebilizumab (anti-CD19), B 淋巴细胞抗原的结合剂 CD19 结合剂
别名 伊奈利珠单抗 | 伊奈珠单抗(抗 CD19)
英文别名 Antibody deficiency due to defect in CD19 antibody | Antibody deficiency due to defect in CD19, included antibody | AW495831 antibody | B lymphocyte antigen CD19 antibody | B lymphocyte surface antigen B4 antibody | B-lymphocyte antigen CD19 antibody | B-
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 CD19
种属反应性 人(Human),小鼠(Mouse)
偶联 Unconjugated
作用类型 结合剂
作用机制 B 淋巴细胞抗原的结合剂 CD19 结合剂

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 28.4 kDa (Light Chain) & 52.1 kDa (Heavy Chain), under reducing conditions; 181.9 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0.
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 1299440-37-1
分子类型 抗体

图片

Inebilizumab (anti-CD19) (Ab170867) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD19 with Inebilizumab (anti-CD19) (Ab170867) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

Inebilizumab (anti-CD19) (Ab170867) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD19 (red) with Inebilizumab (anti-CD19) (Ab170867) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.

Inebilizumab (anti-CD19) (Ab170867) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD19 (red) with Inebilizumab (anti-CD19) (Ab170867). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Inebilizumab (anti-CD19) (Ab170867) - SEC
The purity of Inebilizumab (anti-CD19) (Ab170867) is more than 95% verified by HPLC.

关联靶点(人)

CD19 Tclin B淋巴细胞抗原CD19(B-lymphocyte antigen CD19) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

安全和危险性(GHS)

质量标准

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!

找到5个结果

批号(Lot Number) 证书类型 日期 货号
ZJ24F0911427 分析证书 24-09-29 Ab170867
ZJ24F0911428 分析证书 24-09-29 Ab170867
ZJ24F0911429 分析证书 24-09-29 Ab170867
ZJ23F1001473 分析证书 23-11-01 Ab170867
ZJ23F1001474 分析证书 23-11-01 Ab170867

可替换产品

参考文献

1. Tedder TF, Isaacs CM.  (1989)  Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily..  J Immunol,  143  (2): (712-7).  [PMID:2472450]
2. Herbst R, Wang Y, Gallagher S, Mittereder N, Kuta E, Damschroder M, Woods R, Rowe DC, Cheng L, Cook K et al..  (2010)  B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody..  J Pharmacol Exp Ther,  335  (1): (213-22).  [PMID:20605905]
3. Horton HM, Bernett MJ, Pong E, Peipp M, Karki S, Chu SY, Richards JO, Vostiar I, Joyce PF, Repp R et al..  (2008)  Potent in vitro and in vivo activity of an Fc-engineered anti-CD19 monoclonal antibody against lymphoma and leukemia..  Cancer Res,  68  (19): (8049-57).  [PMID:18829563]
4. Zammarchi F, Corbett S, Adams L, Tyrer PC, Kiakos K, Janghra N, Marafioti T, Britten CE, Havenith CEG, Chivers S et al..  (2018)  ADCT-402, a PBD dimer-containing antibody drug conjugate targeting CD19-expressing malignancies..  Blood,  131  (10): (1094-1105).  [PMID:29298756]
5. Zhou, L J LJ, Ord, D C DC, Omori, S A SA and Tedder, T F TF..  (1992)  Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes..  Immunogenetics,  [PMID:1370948]
6. Carter, R H RH and Fearon, D T DT..  (1992)  CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes..  Science (New York, N.Y.),  (3): [PMID:1373518]
7. Kozmik, Z Z, Wang, S S, Dörfler, P P, Adams, B B and Busslinger, M M..  (1992)  The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP..  Molecular and cellular biology,  [PMID:1375324]
8. Bradbury, L E LE, Kansas, G S GS, Levy, S S, Evans, R L RL and Tedder, T F TF..  (1992)  The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules..  Journal of immunology (Baltimore, Md. : 1950),  (1): [PMID:1383329]
9. Matsumoto, A K AK and 5 more authors..  (1991)  Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19..  The Journal of experimental medicine,  (1): [PMID:1702139]
10. Stamenkovic, I I and Seed, B B..  (1988)  CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail..  The Journal of experimental medicine,  (1): [PMID:2459292]
11. Buhl, A M AM, Pleiman, C M CM, Rickert, R C RC and Cambier, J C JC..  (1997)  Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization..  The Journal of experimental medicine,  (1): [PMID:9382888]
12. Brooks, S R SR, Li, X X, Volanakis, E J EJ and Carter, R H RH..  (2000)  Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines..  Journal of immunology (Baltimore, Md. : 1950),  (15): [PMID:10706702]
13. Kuroki, K K and 10 more authors..  (2002)  Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese..  Genes and immunity,  [PMID:12215898]
14. Wang, Yue Y and 5 more authors..  (2002)  The physiologic role of CD19 cytoplasmic tyrosines..  Immunity,  [PMID:12387743]
15. Martin, Joel J and 121 more authors..  (2004)  The sequence and analysis of duplication-rich human chromosome 16..  Nature,  (23): [PMID:15616553]
16. Shoham, Tsipi T, Rajapaksa, Ranjani R, Kuo, Chiung-Chi CC, Haimovich, Joseph J and Levy, Shoshana S..  (2006)  Building of the tetraspanin web: distinct structural domains of CD81 function in different cellular compartments..  Molecular and cellular biology,  [PMID:16449649]
17. van Zelm, Menno C MC and 10 more authors..  (2006)  An antibody-deficiency syndrome due to mutations in the CD19 gene..  The New England journal of medicine,  (4): [PMID:16672701]
18. Zugmaier, Gerhard G, Klinger, Matthias M, Schmidt, Margit M and Subklewe, Marion M..  (2015)  Clinical overview of anti-CD19 BiTE(®) and ex vivo data from anti-CD33 BiTE(®) as examples for retargeting T cells in hematologic malignancies..  Molecular immunology,  [PMID:25883042]
19. Gallagher, Sandra S and 7 more authors..  (2016)  MEDI-551 Treatment Effectively Depletes B Cells and Reduces Serum Titers of Autoantibodies in Mice Transgenic for Sle1 and Human CD19..  Arthritis & rheumatology (Hoboken, N.J.),  [PMID:26606525]
20. Gallagher, Sandra S and 7 more authors..  (2016)  Pharmacological profile of MEDI-551, a novel anti-CD19 antibody, in human CD19 transgenic mice..  International immunopharmacology,  [PMID:27163209]
21. Teplyakov, Alexey A, Obmolova, Galina G, Luo, Jinquan J and Gilliland, Gary L GL..  (2018)  Crystal structure of B-cell co-receptor CD19 in complex with antibody B43 reveals an unexpected fold..  Proteins,  [PMID:29490423]
22. Wang, Michael and 24 more authors..  (2020)  KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma..  The New England journal of medicine,  (2): [PMID:32242358]

溶液计算器