Bivatuzumab (anti-CD44v6), CD44 抗原结合剂的结合剂

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
功能和特点
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
有货

库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab176619-100μg
100μg 现货 Stock Image
Ab176619-1mg
1mg 现货 Stock Image
Ab176619-5mg
5mg 现货 Stock Image
Ab176619-10mg
10mg 期货 Stock Image

基本信息

产品名称 Bivatuzumab (anti-CD44v6), CD44 抗原结合剂的结合剂
别名 比伐珠单抗 | 比伐妥珠单抗 | 抗CD44v6抗体 | 比伐珠单抗(抗 CD44v6)
英文别名 CD44 antibody | CD44 antigen antibody | CD44 isoform(s) antibody | CD44 molecule (Indian blood group) antibody | CD44 molecule antibody | Cd44 variant(s) antibody | CD44_HUMAN antibody | Cd44v antibody | CDw44 antibody | Cell surface glycoprotein CD44 ant
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 CD44
种属反应性 人(Human)
偶联 Unconjugated
作用类型 结合剂
作用机制 CD44 抗原结合剂的结合剂

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 143.22 kDa
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0.
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 214559-60-1
分子类型 抗体

图片

Bivatuzumab (anti-CD44v6) (Ab176619) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD44v6 with Bivatuzumab (anti-CD44v6) (Ab176619) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

Bivatuzumab (anti-CD44v6) (Ab176619) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD44v6 (red) with Bivatuzumab (anti-CD44v6) (Ab176619) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.

Bivatuzumab (anti-CD44v6) (Ab176619) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling CD44v6 (red) with Bivatuzumab (anti-CD44v6) (Ab176619). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Bivatuzumab (anti-CD44v6) (Ab176619) - SEC
The purity of Bivatuzumab (anti-CD44v6) (Ab176619) is more than 95% verified by HPLC.

Bivatuzumab (anti-CD44v6) (Ab176619) - ELISA
Immobilized Recombinant Human CD44 protein (rp169584) at 1.0 μg/mL can bind Bivatuzumab (anti-CD44v6) (Ab176619) with the EC50 of 15.8 ng/mL.

关联靶点(人)

CD44 Tbio CD44抗原(CD44 antigen) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

安全和危险性(GHS)

质量标准

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找到6个结果

批号(Lot Number) 证书类型 日期 货号
ZJ24F1214857 分析证书 24-12-05 Ab176619
ZJ24F1214856 分析证书 24-12-05 Ab176619
ZJ24F1214855 分析证书 24-12-05 Ab176619
ZJ24F0708073 分析证书 24-07-10 Ab176619
ZJ23F1202064 分析证书 23-12-20 Ab176619
ZJ23F1202065 分析证书 23-12-20 Ab176619

参考文献

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18. Telen, M J MJ and 5 more authors..  (1996)  A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding..  The Journal of biological chemistry,  (22): [PMID:8636151]
19. Peck, D D and Isacke, C M CM..  (1998)  Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325..  Journal of cell science,  [PMID:9580567]
20. Chiu, R K RK, Carpenito, C C, Dougherty, S T ST, Hayes, G M GM and Dougherty, G J GJ..  (1999)  Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44..  Neoplasia (New York, N.Y.),  [PMID:10933060]
21. Legg, James W JW, Lewis, Charlotte A CA, Parsons, Maddy M, Ng, Tony T and Isacke, Clare M CM..  (2002)  A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility..  Nature cell biology,  [PMID:12032545]
22. Ponta, Helmut H, Sherman, Larry L and Herrlich, Peter A PA..  (2003)  CD44: from adhesion molecules to signalling regulators..  Nature reviews. Molecular cell biology,  [PMID:12511867]
23. Gasbarri, A A and 5 more authors..  (2003)  CD44s adhesive function spontaneous and PMA-inducible CD44 cleavage are regulated at post-translational level in cells of melanocytic lineage..  Melanoma research,  [PMID:12883358]
24. Teriete, Peter P and 12 more authors..  (2004)  Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44..  Molecular cell,  (27): [PMID:14992719]
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