Tregalizumab (anti-CD4), T 细胞表面抗原 CD4 激动剂的激动剂

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
功能和特点
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 小鼠(Mouse)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
有货

库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab170850-100μg
100μg 现货 Stock Image
Ab170850-1mg
1mg 现货 Stock Image
Ab170850-5mg
5mg 现货 Stock Image
Ab170850-10mg
10mg 期货 Stock Image

基本信息

产品名称 Tregalizumab (anti-CD4), T 细胞表面抗原 CD4 激动剂的激动剂
别名 曲利组单抗 | 特瑞加珠单抗(抗 CD4)
英文别名 CD 4 antibody | CD4 (L3T4) antibody | CD4 antibody | CD4 antigen (p55) antibody | CD4 antigen antibody | CD4 molecule antibody | CD4 receptor antibody | CD4+ Lymphocyte deficiency, included antibody | CD4_HUMAN antibody | CD4mut antibody | L3T4 antibody |
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 CD4
种属反应性 人(Human),小鼠(Mouse)
偶联 Unconjugated
作用类型 激动剂
作用机制 T 细胞表面抗原 CD4 激动剂的激动剂

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 27.2 kDa (Light Chain) & 51.5 kDa (Heavy Chain), under reducing conditions; 165.5 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 1207446-68-1
分子类型 抗体

图片

Tregalizumab (anti-CD4) (Ab170850) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD4 with Tregalizumab (anti-CD4) (Ab170850) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

Tregalizumab (anti-CD4) (Ab170850) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD4 (red) with Tregalizumab (anti-CD4) (Ab170850) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.


Tregalizumab (anti-CD4) (Ab170850) - SEC
The purity of Tregalizumab (anti-CD4) (Ab170850) is more than 95% verified by HPLC.

关联靶点(人)

CD4 Tclin T 细胞表面糖蛋白 CD4(T-cell surface glycoprotein CD4) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

安全和危险性(GHS)

质量标准

质检证书(CoA,COO,BSE/TSE 和分析图谱)

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找到5个结果

批号(Lot Number) 证书类型 日期 货号
ZJ24F1012876 分析证书 24-10-25 Ab170850
ZJ24F1012875 分析证书 24-10-25 Ab170850
ZJ24F1012874 分析证书 24-10-25 Ab170850
ZJ23F1202088 分析证书 23-12-20 Ab170850
ZJ23F1202087 分析证书 23-12-20 Ab170850

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参考文献

1. Burkly LC, Olson D, Shapiro R, Winkler G, Rosa JJ, Thomas DW, Williams C, Chisholm P.  (1992)  Inhibition of HIV infection by a novel CD4 domain 2-specific monoclonal antibody. Dissecting the basis for its inhibitory effect on HIV-induced cell fusion..  J Immunol,  149  (5): (1779-87).  [PMID:1380539]
2. Wilkinson RA, Pincus SH, Song K, Shepard JB, Weaver AJ, Labib ME, Teintze M..  (2013)  Improved guanide compounds which bind the CXCR4 co-receptor and inhibit HIV-1 infection..  Bioorg Med Chem Lett,  23  (7): (2197-2201).  [PMID:23434419] [10.1016/j.bmcl.2013.01.107]
3. Lumangtad LA, Bell TW..  (2020)  The signal peptide as a new target for drug design..  Bioorg Med Chem Lett,  30  (10): (127115-127115).  [PMID:32209293] [10.1016/j.bmcl.2020.127115]
4. Lumangtad LA,Claeys E,Hamal S,Intasiri A,Basrai C,Yen-Pon E,Beenfeldt D,Vermeire K,Bell TW.  (2020)  Syntheses and anti-HIV and human cluster of differentiation 4 (CD4) down-modulating potencies of pyridine-fused cyclotriazadisulfonamide (CADA) compounds..  Bioorg Med Chem,  28  (24): (115816-115816).  [PMID:33181479] [10.1016/j.bmc.2020.115816]
5. Fomsgaard, A A, Hirsch, V M VM and Johnson, P R PR..  (1992)  Cloning and sequences of primate CD4 molecules: diversity of the cellular receptor for simian immunodeficiency virus/human immunodeficiency virus..  European journal of immunology,  [PMID:1425921]
6. Crise, B B and Rose, J K JK..  (1992)  Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor..  The Journal of biological chemistry,  (5): [PMID:1618861]
7. Wang, J H JH and 9 more authors..  (1990)  Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains..  Nature,  (29): [PMID:1701030]
8. Hodge, T W TW, Sasso, D R DR and McDougal, J S JS..  (1991)  Humans with OKT4-epitope deficiency have a single nucleotide base change in the CD4 gene, resulting in substitution of TRP240 for ARG240..  Human immunology,  [PMID:1708753]
9. Spellman, M W MW, Leonard, C K CK, Basa, L J LJ, Gelineo, I I and van Halbeek, H H..  (1991)  Carbohydrate structures of recombinant soluble human CD4 expressed in Chinese hamster ovary cells..  Biochemistry,  (5): [PMID:2001369]
10. Crise, B B, Buonocore, L L and Rose, J K JK..  (1990)  CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor..  Journal of virology,  [PMID:2214026]
11. Ryu, S E SE and 9 more authors..  (1990)  Crystal structure of an HIV-binding recombinant fragment of human CD4..  Nature,  (29): [PMID:2247146]
12. Carr, S A SA and 7 more authors..  (1989)  Protein and carbohydrate structural analysis of a recombinant soluble CD4 receptor by mass spectrometry..  The Journal of biological chemistry,  (15): [PMID:2592374]
13. Doyle, C C and Strominger, J L JL..  (1987)  Interaction between CD4 and class II MHC molecules mediates cell adhesion..  Nature,  [PMID:2823150]
14. Maddon, P J PJ and 5 more authors..  (1985)  The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family..  Cell,  [PMID:2990730]
15. Littman, D R DR, Maddon, P J PJ and Axel, R R..  (1988)  Corrected CD4 sequence..  Cell,  (18): [PMID:3263213]
16. Lusso, P P and 5 more authors..  (1994)  CD4 is a critical component of the receptor for human herpesvirus 7: interference with human immunodeficiency virus..  Proceedings of the National Academy of Sciences of the United States of America,  (26): [PMID:7909607]
17. Winkel, K K, Sotzik, F F, Vremec, D D, Cameron, P U PU and Shortman, K K..  (1994)  CD4 and CD8 expression by human and mouse thymic dendritic cells..  Immunology letters,  [PMID:8088877]
18. Aiken, C C, Konner, J J, Landau, N R NR, Lenburg, M E ME and Trono, D D..  (1994)  Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain..  Cell,  (11): [PMID:8124721]
19. Ansari-Lari, M A MA and 7 more authors..  (1996)  A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13..  Genome research,  [PMID:8723724]
20. Ansari-Lari, M A MA, Shen, Y Y, Muzny, D M DM, Lee, W W and Gibbs, R A RA..  (1997)  Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination..  Genome research,  [PMID:9074930]
21. Wu, H H, Kwong, P D PD and Hendrickson, W A WA..  (1997)  Dimeric association and segmental variability in the structure of human CD4..  Nature,  (29): [PMID:9168119]
22. Kwong, P D PD and 5 more authors..  (1998)  Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody..  Nature,  (18): [PMID:9641677]
23. Zeitlmann, L L, Sirim, P P, Kremmer, E E and Kolanus, W W..  (2001)  Cloning of ACP33 as a novel intracellular ligand of CD4..  The Journal of biological chemistry,  (23): [PMID:11113139]
24. Fragoso, Roben R and 5 more authors..  (2003)  Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling..  Journal of immunology (Baltimore, Md. : 1950),  (15): [PMID:12517957]
25. Sharma, Deepak D and 7 more authors..  (2005)  Protein minimization of the gp120 binding region of human CD4..  Biochemistry,  (13): [PMID:16331979]
26. Löwenberg, Mark M and 7 more authors..  (2006)  Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN..  EMBO reports,  [PMID:16888650]
27. Bernstein, Helene B HB and 5 more authors..  (2006)  CD4 expression on activated NK cells: ligation of CD4 induces cytokine expression and cell migration..  Journal of immunology (Baltimore, Md. : 1950),  (15): [PMID:16951326]
28. Lindwasser, O Wolf OW, Chaudhuri, Rittik R and Bonifacino, Juan S JS..  (2007)  Mechanisms of CD4 downregulation by the Nef and Vpu proteins of primate immunodeficiency viruses..  Current molecular medicine,  [PMID:17346169]
29. Garron, Marie-Line ML and 5 more authors..  (2008)  Structural basis for the interaction between focal adhesion kinase and CD4..  Journal of molecular biology,  (1): [PMID:18078954]
30. Wang, Xin Xiang XX and 7 more authors..  (2011)  Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex..  Proceedings of the National Academy of Sciences of the United States of America,  (20): [PMID:21900604]
31. Fernandes, Rosa Anita and 11 more authors..  (2019)  Complete Multilineage CD4 Expression Defect Associated With Warts Due to an Inherited Homozygous CD4 Gene Mutation..  Frontiers in immunology,  [PMID:31781092]

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