| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab170728-100μg |
100μg |
现货  |
| |
| Ab170728-1mg |
1mg |
现货 |
| |
| Ab170728-5mg |
5mg |
现货 |
| |
| Ab170728-10mg |
10mg |
期货 |
|
| 产品名称 | Ibalizumab (anti-CD4), T 细胞表面抗原 CD4 抑制剂 |
|---|---|
| 别名 | 伊巴组单抗 | 伊巴利珠单抗(抗 CD4) |
| 英文别名 | Ibalizumab | TMB-355 | TNX-355 | CD 4 antibody | CD4 (L3T4) antibody | CD4 antibody | CD4 antigen (p55) antibody | CD4 antigen antibody | CD4 molecule antibody | CD4 receptor antibody | CD4+ Lymphocyte deficiency, included antibody | CD4_HUMAN antibody | |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | CD4 |
| 应用 | ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt |
| 种属反应性 | 人(Human),食蟹猴(Cynomolgus monkey) |
| 偶联 | Unconjugated |
| 作用类型 | 抑制剂 |
| 作用机制 | T 细胞表面抗原 CD4 抑制剂 |
| 抗体类型 | Primary antibody |
|---|---|
| 克隆类型 | 重组抗体 |
| Format | Whole IgG |
| 亚型 | Human IgG4SP |
| 轻链亚型 | kappa |
| SDS-PAGE | 147.36 kDa |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 来源 | CHO supernatant |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 680188-33-4 |
| 分子类型 | 抗体 |
Ibalizumab (anti-CD4) (Ab170728) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD4 with Ibalizumab (anti-CD4) (Ab170728) (right panel) compared with Human IgG (Ab170213) - Isotype Control (left panel) and detected with Goat Anti-Human IgG (FITC) (Ab175834).
Ibalizumab (anti-CD4) (Ab170728) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD4 (red) with Ibalizumab (anti-CD4) (Ab170728) and detected with Goat Anti-Human IgG (FITC) (Ab175834). Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Ibalizumab (anti-CD4) (Ab170728) - SEC
The purity of Ibalizumab (anti-CD4) (Ab170728) is more than 95% verified by HPLC.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 ZJ24F0911549 |
分析证书 | 24-09-30 | Ab170728 |
| ZJ24F0911548 |
分析证书 | 24-09-30 | Ab170728 |
| ZJ24F0911547 |
分析证书 | 24-09-30 | Ab170728 |
| ZJ23F1001369 |
分析证书 | 23-10-18 | Ab170728 |
| ZJ23F1001370 |
分析证书 | 23-10-18 | Ab170728 |
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| 1. Burkly LC, Olson D, Shapiro R, Winkler G, Rosa JJ, Thomas DW, Williams C, Chisholm P. (1992) Inhibition of HIV infection by a novel CD4 domain 2-specific monoclonal antibody. Dissecting the basis for its inhibitory effect on HIV-induced cell fusion.. J Immunol, 149 (5): (1779-87). [PMID:1380539] |
| 2. Wilkinson RA, Pincus SH, Song K, Shepard JB, Weaver AJ, Labib ME, Teintze M.. (2013) Improved guanide compounds which bind the CXCR4 co-receptor and inhibit HIV-1 infection.. Bioorg Med Chem Lett, 23 (7): (2197-2201). [PMID:23434419] [10.1016/j.bmcl.2013.01.107] |
| 3. Lumangtad LA, Bell TW.. (2020) The signal peptide as a new target for drug design.. Bioorg Med Chem Lett, 30 (10): (127115-127115). [PMID:32209293] [10.1016/j.bmcl.2020.127115] |
| 4. Lumangtad LA,Claeys E,Hamal S,Intasiri A,Basrai C,Yen-Pon E,Beenfeldt D,Vermeire K,Bell TW. (2020) Syntheses and anti-HIV and human cluster of differentiation 4 (CD4) down-modulating potencies of pyridine-fused cyclotriazadisulfonamide (CADA) compounds.. Bioorg Med Chem, 28 (24): (115816-115816). [PMID:33181479] [10.1016/j.bmc.2020.115816] |
| 5. Fomsgaard, A A, Hirsch, V M VM and Johnson, P R PR.. (1992) Cloning and sequences of primate CD4 molecules: diversity of the cellular receptor for simian immunodeficiency virus/human immunodeficiency virus.. European journal of immunology, [PMID:1425921] |
| 6. Crise, B B and Rose, J K JK.. (1992) Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor.. The Journal of biological chemistry, (5): [PMID:1618861] |
| 7. Wang, J H JH and 9 more authors.. (1990) Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains.. Nature, (29): [PMID:1701030] |
| 8. Hodge, T W TW, Sasso, D R DR and McDougal, J S JS.. (1991) Humans with OKT4-epitope deficiency have a single nucleotide base change in the CD4 gene, resulting in substitution of TRP240 for ARG240.. Human immunology, [PMID:1708753] |
| 9. Spellman, M W MW, Leonard, C K CK, Basa, L J LJ, Gelineo, I I and van Halbeek, H H.. (1991) Carbohydrate structures of recombinant soluble human CD4 expressed in Chinese hamster ovary cells.. Biochemistry, (5): [PMID:2001369] |
| 10. Crise, B B, Buonocore, L L and Rose, J K JK.. (1990) CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor.. Journal of virology, [PMID:2214026] |
| 11. Ryu, S E SE and 9 more authors.. (1990) Crystal structure of an HIV-binding recombinant fragment of human CD4.. Nature, (29): [PMID:2247146] |
| 12. Carr, S A SA and 7 more authors.. (1989) Protein and carbohydrate structural analysis of a recombinant soluble CD4 receptor by mass spectrometry.. The Journal of biological chemistry, (15): [PMID:2592374] |
| 13. Doyle, C C and Strominger, J L JL.. (1987) Interaction between CD4 and class II MHC molecules mediates cell adhesion.. Nature, [PMID:2823150] |
| 14. Maddon, P J PJ and 5 more authors.. (1985) The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.. Cell, [PMID:2990730] |
| 15. Littman, D R DR, Maddon, P J PJ and Axel, R R.. (1988) Corrected CD4 sequence.. Cell, (18): [PMID:3263213] |
| 16. Lusso, P P and 5 more authors.. (1994) CD4 is a critical component of the receptor for human herpesvirus 7: interference with human immunodeficiency virus.. Proceedings of the National Academy of Sciences of the United States of America, (26): [PMID:7909607] |
| 17. Winkel, K K, Sotzik, F F, Vremec, D D, Cameron, P U PU and Shortman, K K.. (1994) CD4 and CD8 expression by human and mouse thymic dendritic cells.. Immunology letters, [PMID:8088877] |
| 18. Aiken, C C, Konner, J J, Landau, N R NR, Lenburg, M E ME and Trono, D D.. (1994) Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain.. Cell, (11): [PMID:8124721] |
| 19. Ansari-Lari, M A MA and 7 more authors.. (1996) A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.. Genome research, [PMID:8723724] |
| 20. Ansari-Lari, M A MA, Shen, Y Y, Muzny, D M DM, Lee, W W and Gibbs, R A RA.. (1997) Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.. Genome research, [PMID:9074930] |
| 21. Wu, H H, Kwong, P D PD and Hendrickson, W A WA.. (1997) Dimeric association and segmental variability in the structure of human CD4.. Nature, (29): [PMID:9168119] |
| 22. Kwong, P D PD and 5 more authors.. (1998) Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody.. Nature, (18): [PMID:9641677] |
| 23. Zeitlmann, L L, Sirim, P P, Kremmer, E E and Kolanus, W W.. (2001) Cloning of ACP33 as a novel intracellular ligand of CD4.. The Journal of biological chemistry, (23): [PMID:11113139] |
| 24. Fragoso, Roben R and 5 more authors.. (2003) Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:12517957] |
| 25. Sharma, Deepak D and 7 more authors.. (2005) Protein minimization of the gp120 binding region of human CD4.. Biochemistry, (13): [PMID:16331979] |
| 26. Löwenberg, Mark M and 7 more authors.. (2006) Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN.. EMBO reports, [PMID:16888650] |
| 27. Bernstein, Helene B HB and 5 more authors.. (2006) CD4 expression on activated NK cells: ligation of CD4 induces cytokine expression and cell migration.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:16951326] |
| 28. Lindwasser, O Wolf OW, Chaudhuri, Rittik R and Bonifacino, Juan S JS.. (2007) Mechanisms of CD4 downregulation by the Nef and Vpu proteins of primate immunodeficiency viruses.. Current molecular medicine, [PMID:17346169] |
| 29. Garron, Marie-Line ML and 5 more authors.. (2008) Structural basis for the interaction between focal adhesion kinase and CD4.. Journal of molecular biology, (1): [PMID:18078954] |
| 30. Wang, Xin Xiang XX and 7 more authors.. (2011) Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.. Proceedings of the National Academy of Sciences of the United States of America, (20): [PMID:21900604] |
| 31. Fernandes, Rosa Anita and 11 more authors.. (2019) Complete Multilineage CD4 Expression Defect Associated With Warts Due to an Inherited Homozygous CD4 Gene Mutation.. Frontiers in immunology, [PMID:31781092] |
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