CD6/T12 Mouse mAb

    应用:
  • Flow Cytometry
功能和特点
  • 宿主种属: 小鼠(Mouse)
  • 种属反应性: 人(Human)
  • 亚型: Mouse IgG1
  • 克隆号: HI210
  • 偶联: Unconjugated
有货

库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab095071-10μg
10μg 现货 Stock Image
Ab095071-50μg
50μg 现货 Stock Image
Ab095071-100μg
100μg 期货 Stock Image
Ab095071-1mg
1mg 期货 Stock Image

基本信息

产品名称 CD6/T12 Mouse mAb
别名 CD6/T12抗体 | CD6分子(CD6)抗体 | CD6/T12小鼠单克隆抗体 | CD6/T12小鼠单抗
英文别名 T12 | TP120 | TP120 | CD6 antigenFLJ44171 | CD6 molecule | CD6 | T12 | Tp120 | TP120T-cell differentiation antigen CD6 | CD_antigen=CD6 antibody | CD6 antibody | CD6 antigen Tp120 antibody | CD6 molecule antibody | CD6_HUMAN antibody | FLJ44171 antibody |
规格或纯度 无载体, ExactAb™, 已验证, 见COA
宿主种属 小鼠(Mouse)
特异性 CD6/T12
种属反应性 人(Human)
免疫原 Fetal thymocytes
阳性对照 Flow: Human peripheral blood lymphocytes.
偶联 Unconjugated

产品属性

克隆类型 单克隆抗体
克隆号 HI210
Format Whole IgG
亚型 Mouse IgG1
轻链亚型 kappa
SDS-PAGE 150 kDa
纯化方法 Protein A purified
物理外观 Liquid
储存缓冲液 10mM PBS, 0.1% Sodium azide, pH 7.2
防腐剂 0.1% Sodium azide
浓度 见COA
储存温度 2-8°C储存
运输条件 冰袋运输
稳定性与储存 4°C 下运输。4°C 长期保存(36 个月)。收货后建议分装。
分子类型 抗体

图片

CD6/T12 Mouse mAb (Ab095071) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD6/T12 with CD6/T12 Mouse mAb (Ab095071) conjugated with biotin (right panel) at 0.5 μg/mL for 1 hour at 4°C, compared with Mouse IgG Isotype Control Antibody (Biotin) (Ab180306) (left panel) and detected with SA-PE (rp156150). 

CD6/T12 Mouse mAb (Ab095071) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD6/T12 (red) with CD6/T12 Mouse mAb (Ab095071) conjugated with biotin at 0.5 μg/mL for 1 hour at 4°C, and detected with SA-PE (rp156150). Blue - Mouse IgG Isotype Control Antibody (Biotin) (Ab180306). Black - Unlabelled control, cells without incubation with primary antibody.

关联靶点(人)

CD6 Tbio T细胞分化抗原CD6(T-cell differentiation antigen CD6) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

安全和危险性(GHS)

质量标准

应用

应用名称 稀释比例
Flow Cytometry

< 0.5µg/100w cells

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到3个结果

批号(Lot Number) 证书类型 日期 货号
ZJ24F0707910 分析证书 24-07-08 Ab095071
ZJ24F0707909 分析证书 24-07-08 Ab095071
ZJ24F0707911 分析证书 24-07-08 Ab095071

参考文献

1. Alonso R, Huerta V, de Leon J, Piedra P, Puchades Y, Guirola O, Chinea G, Montero E.  (2008)  Towards the definition of a chimpanzee and human conserved CD6 domain 1 epitope recognized by T1 monoclonal antibody..  Hybridoma (Larchmt),  27  (4): (291-301).  [PMID:18707547]
2. Todd D Taylor,Hideki Noguchi,Yasushi Totoki,Atsushi Toyoda,Yoko Kuroki,Ken Dewar,Christine Lloyd,Takehiko Itoh,Tadayuki Takeda,Dae-Won Kim,Xinwei She,Karen F Barlow,Toby Bloom,Elspeth Bruford,Jean L Chang,Christina A Cuomo,Evan Eichler,Michael G FitzGerald,David B Jaffe,Kurt LaButti,Robert Nicol,Hong-Seog Park,Christopher Seaman,Carrie Sougnez,Xiaoping Yang,Andrew R Zimmer,Michael C Zody,Bruce W Birren,Chad Nusbaum,Asao Fujiyama,Masahira Hattori,Jane Rogers,Eric S Lander,Yoshiyuki Sakaki.  (2006-03-24)  Human chromosome 11 DNA sequence and analysis including novel gene identification..  Nature,  440  ((7083)): (497-500).  [PMID:16554811]
3. Aruffo, A A, Melnick, M B MB, Linsley, P S PS and Seed, B B..  (1991)  The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins..  The Journal of experimental medicine,  (1): [PMID:1919444]
4. Swack, J A JA, Mier, J W JW, Romain, P L PL, Hull, S R SR and Rudd, C E CE..  (1991)  Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule..  The Journal of biological chemistry,  (15): [PMID:2016320]
5. Wee, S S and 5 more authors..  (1993)  Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors..  The Journal of experimental medicine,  (1): [PMID:7678115]
6. Bowen, M A MA and 8 more authors..  (1997)  Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms..  Journal of immunology (Baltimore, Md. : 1950),  (1): [PMID:9013954]
7. Gimferrer, Idoia I and 8 more authors..  (2004)  Relevance of CD6-mediated interactions in T cell activation and proliferation..  Journal of immunology (Baltimore, Md. : 1950),  (15): [PMID:15294938]
8. Zimmerman, Aukje W AW and 5 more authors..  (2006)  Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells..  Blood,  (15): [PMID:16352806]
9. Hassan, Namir J NJ and 7 more authors..  (2006)  CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76..  Molecular and cellular biology,  [PMID:16914752]
10. Castro, Mónica A A MA and 11 more authors..  (2007)  Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse..  Journal of immunology (Baltimore, Md. : 1950),  (1): [PMID:17371992]
11. Sarrias, Maria-Rosa MR and 10 more authors..  (2007)  CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock..  Proceedings of the National Academy of Sciences of the United States of America,  (10): [PMID:17601777]
12. Roncagalli, Romain R and 16 more authors..  (2014)  Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub..  Nature immunology,  [PMID:24584089]
13. Escoda-Ferran, Cristina C and 8 more authors..  (2014)  Modulation of CD6 function through interaction with Galectin-1 and -3..  FEBS letters,  (25): [PMID:24945728]
14. Chappell, Paul E PE and 8 more authors..  (2015)  Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction..  Structure (London, England : 1993),  (4): [PMID:26146185]

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