首页   400-620-6333
为了更好地浏览阿拉丁的产品，请在使用“QQ浏览器”或“360浏览器”时切换到极速模式。查看明细
  • 登录
  • 注册
  • 英文站
切换导航
我的购物车
搜索
搜索444
高级搜索
菜单
登录
设置
྾

壬二酸

5α还原酶抑制剂。PPARγ激活剂。
6篇引用文献
有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
A108439-25g
 25g 现货 Stock Image
A108439-100g
 100g 现货 Stock Image
A108439-500g
 500g 现货 Stock Image
A108439-2.5kg
 2.5kg 现货 Stock Image
大包装询价 收藏夹 比较  SDS中文版  DATASHEET
查看相关系列
羧酸 (2084) 羰基化合物 (2345)
main product photo

基本描述

英文别名 DTXSID8021640 | Azelex | Finacea Foam | MLS000069659 | Acido azelaico | MLS001148615 | Emerox 1110 | Finevin | KBioGR_000662 | Lopac0_000051 | Nonandisaure | Anchoate | SR-01000075671 | NONANEDIOIC ACID
规格或纯度 Moligand™, ≥99%
英文名称 Azelaic acid
生化机理 5α还原酶抑制剂。PPARγ激活剂。竞争性地抑制酪氨酸酶和硫氧还蛋白还原酶（K i值分别为3 mM和13μM）。细胞毒素为黑色素细胞。减少皮肤色素沉着。诱导水杨酸在植物中的积累。
运输条件 常规运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

Azelaic acid is a dicarboxylic acid that exhibits anti-inflammatory activity. It is known for it’s anti acne activity in vitro. Azelaic acid directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and upregulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPARν is thoμght to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays antiacne and anticancer potential as well, inhibiting the proliferation of cutaneous melanoma due to suppression of mitochondrial oxidoreductive activity and DNA synthesis.An antiinflammatory compound

Azelaic acid is a dicarboxylic acid that exhibits anti-inflammatory activity. It is known for it’s anti acne activity in vitro. Azelaic acid directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and upregulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPARν is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays antiacne and anticancer potential as well, inhibiting the proliferation of cutaneous melanoma due to suppression of mitochondrial oxidoreductive activity and DNA synthesis.
An antiinflammatory compound

产品属性

ALogP 1.6

关联靶点（人）

ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CACNA1C Tclin Voltage-gated L-type calcium channel alpha-1C subunit (766 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC29A1 Tclin Equilibrative nucleoside transporter 1 (1711 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2B Tclin Alpha-2b adrenergic receptor (4412 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2C Tclin Alpha-2c adrenergic receptor (4876 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA2A Tclin Adenosine A2a receptor (16305 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BDKRB2 Tclin Bradykinin B2 receptor (3970 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRNA4 Tclin Neuronal acetylcholine receptor protein alpha-4 subunit (1265 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

ampC Beta-lactamase AmpC (62480 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cckar Cholecystokinin A receptor (90 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pde4d Phosphodiesterase 4D (4 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FTL Ferritin light chain (43324 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 488179683
EC号 204-669-1
分子类型 小分子
IUPAC Name nonanedioic acid
INCHI InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
InChi Key BDJRBEYXGGNYIS-UHFFFAOYSA-N
Canonical SMILES C(CCCC(=O)O)CCCC(=O)O
Isomeric SMILES C(CCCC(=O)O)CCCC(=O)O
WGK Germany 1
RTECS CM1980000
PubChem CID 2266
分子量 188.22
Beilstein号 1101094

化学和物理性质

溶解性 Soluble in water (2.4 mg/ml at 20 °C), ethanol (5%), DMSO, methanol (70 mg/ml), and alcohol.
密度 0.821
敏感性 对湿度敏感
折光率 1.4303
闪点(℉) 410 °F
闪点(℃) 210 °C
沸点 286°C
熔点 109-111°C
分子量 188.220 g/mol
XLogP3 1.600
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 4
可旋转键计数Rotatable Bond Count 8
精确质量Exact Mass 188.105 Da
单同位素质量Monoisotopic Mass 188.105 Da
拓扑极表面积Topological Polar Surface Area 74.600 Ų
重原子数Heavy Atom Count 13
形式电荷Formal Charge 0
复杂度Complexity 147.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 Warning
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激
预防措施声明

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染：用水充分清洗。

P321: 特殊处理（请参阅此标签上的...）。

P264: 处理后要彻底洗手。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。
WGK Germany 1
RTECS CM1980000
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

 SDS英文版

质量标准

Melting point 106-109（℃）
Purity(GC) 99-100（%）
Appearance（A108439) white powder
Infrared spectrum Conforms to Structure
Proton NMR spectrum Conforms to Structure
Solubility,Colorless to light yellow liquid(5%,ethanol ) pass

 质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到24个结果

批号(Lot Number) 证书类型 日期 货号
K2422350 分析证书 24-11-25 A108439
K2427338 分析证书 24-11-25 A108439
A2503073 分析证书 24-11-16 A108439
A2503074 分析证书 24-11-16 A108439
J2312103 分析证书 23-09-14 A108439
G2422469 分析证书 23-09-14 A108439
J2408278 分析证书 23-09-14 A108439
J2419005 分析证书 23-09-14 A108439
E2324569 分析证书 23-05-06 A108439
E2324574 分析证书 23-05-06 A108439
E2324575 分析证书 23-05-06 A108439
E2324576 分析证书 23-05-06 A108439
J2210122 分析证书 22-07-14 A108439
J2210123 分析证书 22-07-14 A108439
J2210124 分析证书 22-07-14 A108439
J2210128 分析证书 22-07-14 A108439
B2324338 分析证书 22-07-14 A108439
B2324339 分析证书 22-07-14 A108439
E2311091 分析证书 22-07-14 A108439
F2215186 分析证书 22-06-05 A108439
F2215187 分析证书 22-06-05 A108439
F2215322 分析证书 22-06-05 A108439
E1803118 分析证书 22-03-30 A108439
F2129092 分析证书 21-07-03 A108439

显示更多⌵

可替换产品

  1. 壬二酸
    壬二酸

    ¥89.90

  2. 壬二酸
    壬二酸

    ¥179.90

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?
1. Suleixin Yang, Ka Hong Wong, Peng Hua, Chengwei He, Hua Yu, Dan Shao, Zhi Shi, Meiwan Chen.  (2022)  ROS-responsive fluorinated polyethyleneimine vector to co-deliver shMTHFD2 and shGPX4 plasmids induces ferroptosis and apoptosis for cancer therapy.  Acta Biomaterialia,  140  (492).  [PMID:34879292] [10.1016/j.actbio.2021.11.042]
2. Qi Jing, Jin Feiyang, You Yuchan, Du Yan, Liu Di, Xu Xiaoling, Wang Jun, Zhu Luwen, Chen Minjiang, Shu Gaofeng, Wu Liming, Ji Jiansong, Du Yongzhong.  (2021)  Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles.  Nature Communications,  12  (1): (1-17).  [PMID:34362890] [10.1038/s41467-021-24902-2]
3. Jiujiang Ji, Guo Chen, Jun Zhao.  (2019)  Preparation and characterization of amino/thiol bifunctionalized magnetic nanoadsorbent and its application in rapid removal of Pb (II) from aqueous system.  JOURNAL OF HAZARDOUS MATERIALS,  368  (255).  [PMID:30684763] [10.1016/j.jhazmat.2019.01.035]
4. Gang-Gang Yang, Hang Zhang, Dong-Yang Zhang, Qian Cao, Jing Yang, Liang-Nian Ji, Zong-Wan Mao.  (2018)  Cancer-specific chemotherapeutic strategy based on the vitamin K3 mediated ROS regenerative feedback and visualized drug release in vivo.  BIOMATERIALS,  185  (73).  [PMID:30227273] [10.1016/j.biomaterials.2018.08.065]
5. Shuai Zhang, Na Sha, Zhe Zhao.  (2017)  Surface modification of α-Al2O3 with dicarboxylic acids for the preparation of UV-curable ceramic suspensions.  JOURNAL OF THE EUROPEAN CERAMIC SOCIETY,  37  (1607).  [10.1016/j.jeurceramsoc.2016.12.013]
6. Zhijuan Sun, Xiao Wang, Fei Guo, Chunyue Jiang, Qinmin Pan.  (2016)  Isothermal and nonisothermal crystallization kinetics of bio-sourced nylon 69.  CHINESE JOURNAL OF CHEMICAL ENGINEERING,  24  (638).  [10.1016/j.cjche.2015.12.021]

参考文献

1. Q H Nguyen,T P Bui.  (1995-02-01)  Azelaic acid: pharmacokinetic and pharmacodynamic properties and its therapeutic role in hyperpigmentary disorders and acne..  International journal of dermatology,  34  ((2)): (75-84).  [PMID:7737781]
2.  (1993-06-21)  Azelaic acid--a new topical treatment for acne..  Drug and therapeutics bulletin,  31  ((13)): (50-52).  [PMID:8344141]
3. G F Hoffmann,W Meier-Augenstein,S Stöckler,R Surtees,D Rating,W L Nyhan.  (1993-01-01)  Physiology and pathophysiology of organic acids in cerebrospinal fluid..  Journal of inherited metabolic disease,  16  ((4)): (648-669).  [PMID:8412012]
4. K Graupe,W J Cunliffe,H P Gollnick,R P Zaumseil.  (1996-01-01)  Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports..  Cutis,  57  ((1 Suppl)): (20-35).  [PMID:8654128]
5. G Hoffmann,S Aramaki,E Blum-Hoffmann,W L Nyhan,L Sweetman.  (1989-04-01)  Quantitative analysis for organic acids in biological samples: batch isolation followed by gas chromatographic-mass spectrometric analysis..  Clinical chemistry,  35  ((4)): (587-595).  [PMID:2702744]
6. F Guneral,C Bachmann.  (1994-06-01)  Age-related reference values for urinary organic acids in a healthy Turkish pediatric population..  Clinical chemistry,  40  ((6)): (862-866).  [PMID:8087979]
7. A S Breathnach.  (1996-01-01)  Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies..  Cutis,  57  ((1 Suppl)): (36-45).  [PMID:8654129]
8. P S Mackrides,A F Shaughnessy.  (1996-12-01)  Azelaic acid therapy for acne..  American family physician,  54  ((8)): (2457-2459).  [PMID:8961845]
9. V Rocamora,L Puig,J Romaní,J M de Moragas.  (1999-08-04)  Amelanotic lentigo maligna melanoma: report of a case and review of the literature..  Cutis,  64  ((1)): (53-56).  [PMID:10431675]
10. J J Russell.  (2000-02-12)  Topical therapy for acne..  American family physician,  61  ((2)): (357-366).  [PMID:10670502]
11. S H Korman,H Mandel,A Gutman.  (2000-07-15)  Characteristic urine organic acid profile in peroxisomal biogenesis disorders..  Journal of inherited metabolic disease,  23  ((4)): (425-428).  [PMID:10896310]
12. G Webster.  (2000-07-18)  Combination azelaic acid therapy for acne vulgaris..  Journal of the American Academy of Dermatology,  43  ((2 Pt 3)): (S47-S50).  [PMID:10898830]
13. J F Hermanns,L Petit,O Martalo,C Piérard-Franchimont,G Cauwenbergh,G E Piérard.  (2000-10-29)  Unraveling the patterns of subclinical pheomelanin-enriched facial hyperpigmentation: effect of depigmenting agents..  Dermatology (Basel, Switzerland),  201  ((2)): (118-122).  [PMID:11053913]
14. James Q Del Rosso.  (2002-12-10)  A status report on the medical management of rosacea: focus on topical therapies..  Cutis,  70  ((5)): (271-275).  [PMID:12469780]
15. David C Liao.  (2003-01-24)  Management of acne..  The Journal of family practice,  52  ((1)): (43-51).  [PMID:12540312]
16. James Q Del Rosso.  (2003-12-19)  Medical treatment of rosacea with emphasis on topical therapies..  Expert opinion on pharmacotherapy,  5  ((1)): (5-13).  [PMID:14680431]
17. James E Frampton,Antona J Wagstaff.  (2004-02-26)  Azelaic acid 15% gel: in the treatment of papulopustular rosacea..  American journal of clinical dermatology,  5  ((1)): (57-64).  [PMID:14979745]
18. Rebat M Halder,Georgianna M Richards.  (2004-04-29)  Management of dyschromias in ethnic skin..  Dermatologic therapy,  17  ((2)): (151-157).  [PMID:15113282]
19. R M Halder,G M Richards.  (2004-08-31)  Topical agents used in the management of hyperpigmentation..  Skin therapy letter,  9  ((6)): (1-3).  [PMID:15334278]
20. Karol Burkhart Lindow.  (2004-12-24)  Rosacea. An overview of diagnosis and management..  Advance for nurse practitioners,  12  ((12)): (27-32).  [PMID:15615217]
21. Kimberly A Cayce,Amy J McMichael,Steven R Feldman.  (2004-12-31)  Hyperpigmentation: an overview of the common afflictions..  Dermatology nursing,  16  ((5)): (401-406).  [PMID:15624705]
22. Sarah Purdy.  (2005-09-02)  Acne vulgaris..  Clinical evidence,  ((13)(13)): (2038-2059).  [PMID:16135322]
23. Heather L Roebuck.  (2005-09-10)  Face up to rosacea..  The Nurse practitioner,  30  ((9)): (24-30).  [PMID:16151303]
24. Jennie B Nally,Diane S Berson.  (2006-02-14)  Topical therapies for rosacea..  Journal of drugs in dermatology : JDD,  5  ((1)): (23-26).  [PMID:16468288]
25. Zoe Diana Draelos.  (2006-03-29)  The rationale for advancing the formulation of azelaic acid vehicles..  Cutis,  77  ((2 Suppl)): (7-11).  [PMID:16566282]
26. Boni Elewski,Diane Thiboutot.  (2006-03-29)  A clinical overview of azelaic acid..  Cutis,  77  ((2 Suppl)): (12-16).  [PMID:16566283]
27. James Q Del Rosso.  (2006-03-29)  The use of topical azelaic acid for common skin disorders other than inflammatory rosacea..  Cutis,  77  ((2 Suppl)): (22-24).  [PMID:16566285]
28. Wolf-Ingo Worret,Joachim W Fluhr.  (2006-04-28)  [Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid]..  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG,  4  ((4)): (293-300).  [PMID:16638058]
29. Rosemarie H Liu,Molly K Smith,Sameh A Basta,Evan R Farmer.  (2006-08-23)  Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials..  Archives of dermatology,  142  ((8)): (1047-1052).  [PMID:16924055]
30. Greg Goodman.  (2006-09-14)  Managing acne vulgaris effectively..  Australian family physician,  35  ((9)): (705-709).  [PMID:16969442]
31. Sarah Purdy.  (2006-09-16)  Acne vulgaris..  Clinical evidence,  ((15)(15)): (2183-2201).  [PMID:16973084]
32. Aditya K Gupta,Melissa D Gover,Keyvan Nouri,Susan Taylor.  (2006-11-14)  The treatment of melasma: a review of clinical trials..  Journal of the American Academy of Dermatology,  55  ((6)): (1048-1065).  [PMID:17097400]
33. Esther J van Zuuren,Aditya K Gupta,Melissa D Gover,Mark Graber,Sally Hollis.  (2006-12-28)  Systematic review of rosacea treatments..  Journal of the American Academy of Dermatology,  56  ((1)): (107-115).  [PMID:17190628]
34. Phedias Diamandis,Jan Wildenhain,Ian D Clarke,Adrian G Sacher,Jeremy Graham,David S Bellows,Erick K M Ling,Ryan J Ward,Leanne G Jamieson,Mike Tyers,Peter B Dirks.  (2007-04-10)  Chemical genetics reveals a complex functional ground state of neural stem cells..  Nature chemical biology,  3  ((5)): (268-273).  [PMID:17417631]
35. Aditya K Gupta,Melissa D Gover.  (2007-05-03)  Azelaic acid (15% gel) in the treatment of acne rosacea..  International journal of dermatology,  46  ((5)): (533-538).  [PMID:17472690]
36. Diane Thiboutot.  (2008-02-06)  Versatility of azelaic acid 15% gel in treatment of inflammatory acne vulgaris..  Journal of drugs in dermatology : JDD,  7  ((1)): (13-16).  [PMID:18246693]
37. Harald Gollnick,Alison Layton.  (2008-09-23)  Azelaic acid 15% gel in the treatment of rosacea..  Expert opinion on pharmacotherapy,  9  ((15)): (2699-2706).  [PMID:18803456]
38. Arun Sreekumar,Laila M Poisson,Thekkelnaycke M Rajendiran,Amjad P Khan,Qi Cao,Jindan Yu,Bharathi Laxman,Rohit Mehra,Robert J Lonigro,Yong Li,Mukesh K Nyati,Aarif Ahsan,Shanker Kalyana-Sundaram,Bo Han,Xuhong Cao,Jaeman Byun,Gilbert S Omenn,Debashis Ghosh,Subramaniam Pennathur,Danny C Alexander,Alvin Berger,Jeffrey R Shuster,John T Wei,Sooryanarayana Varambally,Christopher Beecher,Arul M Chinnaiyan.  (2009-02-13)  Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression..  Nature,  457  ((7231)): (910-914).  [PMID:19212411]
39. Wolfram Gronwald,Matthias S Klein,Raoul Zeltner,Bernd-Detlef Schulze,Stephan W Reinhold,Markus Deutschmann,Ann-Kathrin Immervoll,Carsten A Böger,Bernhard Banas,Kai-Uwe Eckardt,Peter J Oefner.  (2011-03-11)  Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine..  Kidney international,  79  ((11)): (1244-1253).  [PMID:21389975]
40. Esther J van Zuuren,Sharon Kramer,Ben Carter,Mark A Graber,Zbys Fedorowicz.  (2011-03-18)  Interventions for rosacea..  The Cochrane database of systematic reviews,  ((3)): (CD003262-CD003262).  [PMID:21412882]
41. Nicola Castellucci,Giuseppe Falini,Gaetano Angelici,Claudia Tomasini.  (2011-04-14)  Formation of gels in the presence of metal ions..  Amino acids,  41  ((3)): (609-620).  [PMID:21487726]
42. Leon H Kircik.  (2011-06-04)  Efficacy and safety of azelaic acid (AzA) gel 15% in the treatment of post-inflammatory hyperpigmentation and acne: a 16-week, baseline-controlled study..  Journal of drugs in dermatology : JDD,  10  ((6)): (586-590).  [PMID:21637899]
43. Ronald G Wheeland,Sunil Dhawan.  (2011-06-04)  Evaluation of self-treatment of mild-to-moderate facial acne with a blue light treatment system..  Journal of drugs in dermatology : JDD,  10  ((6)): (596-602).  [PMID:21637900]
44. Changgeng Liu,Jie Gan,Yang Zhang,Miao Liang,Xi Shu,Jinian Shu,Bo Yang.  (2011-08-30)  Heterogeneous reaction of suspended phosmet particles with NO3 radicals..  The journal of physical chemistry. A,  115  ((39)): (10744-10748).  [PMID:21870875]
45. A Parodi,F Drago,S Paolino,E Cozzani,R Gallo.  (2011-09-13)  [Treatment of rosacea]..  Annales de dermatologie et de venereologie,  138 Suppl 2  (S158-S162).  [PMID:21907876]
46. James Q Del Rosso,Neal Bhatia.  (2011-09-16)  Azelaic acid gel 15% in the management of papulopustular rosacea: a status report on available efficacy data and clinical application..  Cutis,  88  ((2)): (67-72).  [PMID:21916272]
47. Nan Li,Xiaohong Wu,Weibu Jia,Michelle C Zhang,Fengping Tan,Jerry Zhang.  (2011-11-25)  Effect of ionization and vehicle on skin absorption and penetration of azelaic acid..  Drug development and industrial pharmacy,  38  ((8)): (985-994).  [PMID:22111946]
48. Susan Farshi.  (2011-12-14)  Comparative study of therapeutic effects of 20% azelaic acid and hydroquinone 4% cream in the treatment of melasma..  Journal of cosmetic dermatology,  10  ((4)): (282-287).  [PMID:22151936]
49. Zhichao Liu,Qiang Shi,Don Ding,Reagan Kelly,Hong Fang,Weida Tong.  (2011-12-24)  Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps)..  PLoS computational biology,  7  ((12)): (e1002310-e1002310).  [PMID:22194678]
50. Maria Vinaixa,Miguel Angel Rodriguez,Sara Samino,Marta Díaz,Antoni Beltran,Roger Mallol,Cinta Bladé,Lourdes Ibañez,Xavier Correig,Oscar Yanes.  (2011-12-24)  Metabolomics reveals reduction of metabolic oxidation in women with polycystic ovary syndrome after pioglitazone-flutamide-metformin polytherapy..  PloS one,  6  ((12)): (e29052-e29052).  [PMID:22194988]
51. Pei-Wen Hsieh,Saleh A Al-Suwayeh,Chia-Lang Fang,Chwan-Fwu Lin,Chun-Che Chen,Jia-You Fang.  (2012-04-04)  The co-drug of conjugated hydroquinone and azelaic acid to enhance topical skin targeting and decrease penetration through the skin..  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V,  81  ((2)): (369-378).  [PMID:22469554]
52. Merve Aytekin,R Neslihan Gursoy,Semra Ide,Elif H Soylu,Sueda Hekimoglu.  (2012-04-07)  Formulation and characterization of liquid crystal systems containing azelaic acid for topical delivery..  Drug development and industrial pharmacy,  39  ((2)): (228-239).  [PMID:22480294]
53. Neal D Bhatia,James Q Del Rosso.  (2012-07-11)  Optimal management of papulopustular rosacea: rationale for combination therapy..  Journal of drugs in dermatology : JDD,  11  ((7)): (838-844).  [PMID:22777226]
54. Maria Zoeller,Nadja Stingl,Markus Krischke,Agnes Fekete,Frank Waller,Susanne Berger,Martin J Mueller.  (2012-07-24)  Lipid profiling of the Arabidopsis hypersensitive response reveals specific lipid peroxidation and fragmentation processes: biogenesis of pimelic and azelaic acid..  Plant physiology,  160  ((1)): (365-378).  [PMID:22822212]
55. Tsutomu Matsubara,Naoki Tanaka,Kristopher W Krausz,Soumen K Manna,Dong Wook Kang,Erik R Anderson,Hans Luecke,Andrew D Patterson,Yatrik M Shah,Frank J Gonzalez.  (2012-11-13)  Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis..  Cell metabolism,  16  ((5)): (634-644).  [PMID:23140643]
56. Hamidreza Pazoki-Toroudi,Shahab Babakoohi,Mohammad Ali Nilforoushzadeh,Mansour Nassiri-Kashani,Mohammad Shizarpour,Marjan Ajami,Rouhollah Habibey,Bardia Sadr,Mehdi Rashighi-Firoozabadi,Alireza Firooz.  (2012-11-21)  Therapeutic effects of minoxidil high extra combination therapy in patients with androgenetic alopecia..  Skinmed,  10  ((5)): (276-282).  [PMID:23163069]
57. Robyn S Fallen,Melinda Gooderham.  (2012-12-12)  Rosacea: update on management and emerging therapies..  Skin therapy letter,  17  ((10)): (1-4).  [PMID:23223767]
58. Stefania Briganti,Enrica Flori,Arianna Mastrofrancesco,Daniela Kovacs,Emanuela Camera,Matteo Ludovici,Giorgia Cardinali,Mauro Picardo.  (2013-01-03)  Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts: possible implication of PPARγ..  Experimental dermatology,  22  ((1)): (41-47).  [PMID:23278893]
59. Shanmugam Muthulakshmi,Ramalingam Saravanan.  (2013-01-31)  Protective effects of azelaic acid against high-fat diet-induced oxidative stress in liver, kidney and heart of C57BL/6J mice..  Molecular and cellular biochemistry,  377  ((1-2)): (23-33).  [PMID:23361364]
60. Nitin Chauhan,David A F Ellis.  (2013-02-02)  Rosacea: pathophysiology and management principles..  Facial plastic surgery clinics of North America,  21  ((1)): (127-136).  [PMID:23369595]
61. Alan R Shalita,Ronald Falcon,Alan Olansky,Patricia Iannotta,Arash Akhavan,Doris Day,Anthony Janiga,Prashant Singri,John E Kallal.  (2013-02-05)  Inflammatory acne management with a novel prescription dietary supplement..  Journal of drugs in dermatology : JDD,  11  ((12)): (1428-1433).  [PMID:23377512]
62. J Mark Jackson,Leon H Kircik,Douglas J Lorenz.  (2013-04-03)  Efficacy of extended-release 45 mg oral minocycline and extended-release 45 mg oral minocycline plus 15% azelaic acid in the treatment of acne rosacea..  Journal of drugs in dermatology : JDD,  12  ((3)): (292-298).  [PMID:23545911]
63. Alvin B Coda,Tissa Hata,Jeremiah Miller,David Audish,Paul Kotol,Aimee Two,Faiza Shafiq,Kenshi Yamasaki,Julie C Harper,James Q Del Rosso,Richard L Gallo.  (2013-07-23)  Cathelicidin, kallikrein 5, and serine protease activity\xa0is inhibited during treatment of rosacea with azelaic acid 15% gel..  Journal of the American Academy of Dermatology,  69  ((4)): (570-577).  [PMID:23871720]
64. Xiaoling Zang,Christina M Jones,Tran Q Long,María Eugenia Monge,Manshui Zhou,L DeEtte Walker,Roman Mezencev,Alexander Gray,John F McDonald,Facundo M Fernández.  (2014-06-13)  Feasibility of detecting prostate cancer by ultraperformance liquid chromatography-mass spectrometry serum metabolomics..  Journal of proteome research,  13  ((7)): (3444-3454).  [PMID:24922590]
65. Yosuke Fukutani,Ayaka Hori,Satoshi Tsukada,Ryoichi Sato,Jun Ishii,Akihiko Kondo,Hiroaki Matsunami,Masafumi Yohda.  (2014-12-03)  Improving the odorant sensitivity of olfactory receptor-expressing yeast with accessory proteins..  Analytical biochemistry,  471  (1-8).  [PMID:25449303]
66. Chaemyeong Lee,Sang-Yup Lee.  (2015-02-07)  Mussel-inspired bolaamphiphile sticky self-assemblies for the preparation of magnetic nanoparticles..  Colloids and surfaces. B, Biointerfaces,  127  (89-95).  [PMID:25658196]
67. Fei Li,Xiu-Wei Yang,Kristopher W Krausz,Robert G Nichols,Wei Xu,Andrew D Patterson,Frank J Gonzalez.  (2015-02-26)  Modulation of colon cancer by nutmeg..  Journal of proteome research,  14  ((4)): (1937-1946).  [PMID:25712450]
68. Zhonghua Wang,Yajie Zheng,Baoxin Zhao,Yanping Zhang,Zhe Liu,Jing Xu,Yanhua Chen,Zhao Yang,Fenfen Wang,Huiqing Wang,Jiuming He,Ruiping Zhang,Zeper Abliz.  (2015-05-21)  Human metabolic responses to chronic environmental polycyclic aromatic hydrocarbon exposure by a metabolomic approach..  Journal of proteome research,  14  ((6)): (2583-2593).  [PMID:25990285]
69. Sanket M Shah,Mukul Ashtikar,Ankitkumar S Jain,Dinesh T Makhija,Yuvraj Nikam,Rajiv P Gude,Frank Steiniger,Aarti A Jagtap,Mangal S Nagarsenker,Alfred Fahr.  (2015-05-24)  LeciPlex, invasomes, and liposomes: A skin penetration study..  International journal of pharmaceutics,  490  ((1-2)): (391-403).  [PMID:26002568]
70. Anne Krog Ingerslev,Ibrahim Karaman,Murat Bağcıoğlu,Achim Kohler,Peter Kappel Theil,Knud Erik Bach Knudsen,Mette Skou Hedemann.  (2015-07-03)  Whole Grain Consumption Increases Gastrointestinal Content of Sulfate-Conjugated Oxylipins in Pigs - A Multicompartmental Metabolomics Study..  Journal of proteome research,  14  ((8)): (3095-3110).  [PMID:26133160]
71. Maryam Goudarzi,Waylon M Weber,Juijung Chung,Melanie Doyle-Eisele,Dunstana R Melo,Tytus D Mak,Steven J Strawn,David J Brenner,Raymond Guilmette,Albert J Fornace.  (2015-08-12)  Serum Dyslipidemia Is Induced by Internal Exposure to Strontium-90 in Mice, Lipidomic Profiling Using a Data-Independent Liquid Chromatography-Mass Spectrometry Approach..  Journal of proteome research,  14  ((9)): (4039-4049).  [PMID:26262552]
72. Chaemyeong Lee,Seung-Hyun Kim,Jae-Hyung Jang,Sang-Yup Lee.  (2017-10-25)  Enhanced Cell Adhesion on a Nano-Embossed, Sticky Surface Prepared by the Printing of a DOPA-Bolaamphiphile Assembly Ink..  Scientific reports,  7  ((1)): (13797-13797).  [PMID:29062140]
73. Eric M Jones,Rishi Jajoo,Daniel Cancilla,Nathan B Lubock,Jeffrey Wang,Megan Satyadi,Rocky Cheung,Claire de March,Joshua S Bloom,Hiroaki Matsunami,Sriram Kosuri.  (2019-03-25)  A Scalable, Multiplexed Assay for Decoding GPCR-Ligand Interactions with RNA Sequencing..  Cell systems,  8  ((3)): (254-260).  [PMID:30904378]
74. Seyed Dariush Taherzade,Sara Rojas,Janet Soleimannejad,Patricia Horcajada.  (2020-12-02)  Combined Cutaneous Therapy Using Biocompatible Metal-Organic Frameworks..  Nanomaterials (Basel, Switzerland),  10  ((12)): [PMID:33255580]
75. C Schnopp,M Mempel.  (2011-09-13)  Acne vulgaris in children and adolescents..  Minerva pediatrica,  63  ((4)): (293-304).  [PMID:21909065]
76. Suleixin Yang, Ka Hong Wong, Peng Hua, Chengwei He, Hua Yu, Dan Shao, Zhi Shi, Meiwan Chen.  (2022)  ROS-responsive fluorinated polyethyleneimine vector to co-deliver shMTHFD2 and shGPX4 plasmids induces ferroptosis and apoptosis for cancer therapy.  Acta Biomaterialia,  140  (492).  [PMID:34879292] [10.1016/j.actbio.2021.11.042]
77. Qi Jing, Jin Feiyang, You Yuchan, Du Yan, Liu Di, Xu Xiaoling, Wang Jun, Zhu Luwen, Chen Minjiang, Shu Gaofeng, Wu Liming, Ji Jiansong, Du Yongzhong.  (2021)  Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles.  Nature Communications,  12  (1): (1-17).  [PMID:34362890] [10.1038/s41467-021-24902-2]
78. Jiujiang Ji, Guo Chen, Jun Zhao.  (2019)  Preparation and characterization of amino/thiol bifunctionalized magnetic nanoadsorbent and its application in rapid removal of Pb (II) from aqueous system.  JOURNAL OF HAZARDOUS MATERIALS,  368  (255).  [PMID:30684763] [10.1016/j.jhazmat.2019.01.035]
79. Gang-Gang Yang, Hang Zhang, Dong-Yang Zhang, Qian Cao, Jing Yang, Liang-Nian Ji, Zong-Wan Mao.  (2018)  Cancer-specific chemotherapeutic strategy based on the vitamin K3 mediated ROS regenerative feedback and visualized drug release in vivo.  BIOMATERIALS,  185  (73).  [PMID:30227273] [10.1016/j.biomaterials.2018.08.065]
80. Shuai Zhang, Na Sha, Zhe Zhao.  (2017)  Surface modification of α-Al2O3 with dicarboxylic acids for the preparation of UV-curable ceramic suspensions.  JOURNAL OF THE EUROPEAN CERAMIC SOCIETY,  37  (1607).  [10.1016/j.jeurceramsoc.2016.12.013]
81. Zhijuan Sun, Xiao Wang, Fei Guo, Chunyue Jiang, Qinmin Pan.  (2016)  Isothermal and nonisothermal crystallization kinetics of bio-sourced nylon 69.  CHINESE JOURNAL OF CHEMICAL ENGINEERING,  24  (638).  [10.1016/j.cjche.2015.12.021]

溶液计算器

上海阿拉丁生化科技股份有限公司
© 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。

上海工商 危险品化学品经营许可证（带存储）营业执照(三证合一)