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壬二酸

6篇引用文献
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
A108440-250g
 250g 现货 Stock Image
A108440-1kg
 1kg 现货 Stock Image
A108440-2.5kg
 2.5kg 现货 Stock Image
大包装询价 收藏夹 比较  SDS中文版  DATASHEET
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羧酸 (2084) 羰基化合物 (2345)
main product photo

基本描述

别名 杜鹃花酸
英文别名 DTXSID8021640 | Opera_ID_740 | Spectrum3_000278 | Azelex | Finacea Foam | MLS000069659 | Acido azelaico | MLS001148615 | Emerox 1110 | Finevin | KBioGR_000662 | Lopac0_000051 | Nonandisaure | Spectrum5_001304 | Anchoate | SR-01000075671 | 1,7-Dicarboxyhep
规格或纯度 Moligand™, 工业级, ≥85%(GC)
英文名称 Azelaic acid
应用 有机合成。
运输条件 常规运输
产品介绍

在360℃以上蒸馏时部分形成酸酐。易溶于沸水和乙醇，溶于有机溶剂，微溶于苯。有刺激性。有机合成。

产品属性

ALogP 1.6

关联靶点（人）

ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CACNA1C Tclin Voltage-gated L-type calcium channel alpha-1C subunit (766 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC29A1 Tclin Equilibrative nucleoside transporter 1 (1711 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2B Tclin Alpha-2b adrenergic receptor (4412 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2C Tclin Alpha-2c adrenergic receptor (4876 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA2A Tclin Adenosine A2a receptor (16305 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BDKRB2 Tclin Bradykinin B2 receptor (3970 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRNA4 Tclin Neuronal acetylcholine receptor protein alpha-4 subunit (1265 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

ampC Beta-lactamase AmpC (62480 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cckar Cholecystokinin A receptor (90 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pde4d Phosphodiesterase 4D (4 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FTL Ferritin light chain (43324 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504750548
EC号 204-669-1
分子类型 小分子
IUPAC Name nonanedioic acid
INCHI InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
InChi Key BDJRBEYXGGNYIS-UHFFFAOYSA-N
Canonical SMILES C(CCCC(=O)O)CCCC(=O)O
Isomeric SMILES C(CCCC(=O)O)CCCC(=O)O
WGK Germany 1
RTECS CM1980000
PubChem CID 2266
分子量 188.22
Beilstein号 1101094

化学和物理性质

溶解性 Soluble in water (2.4 mg/ml at 20 °C), ethanol (5%), DMSO, methanol (70 mg/ml), and alcohol.
密度 0.821
敏感性 对湿度敏感
折光率 1.4303
闪点(℉) 410 °F
闪点(℃) 210 °C
沸点 286°C
熔点 109-111°C
分子量 188.220 g/mol
XLogP3 1.600
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 4
可旋转键计数Rotatable Bond Count 8
精确质量Exact Mass 188.105 Da
单同位素质量Monoisotopic Mass 188.105 Da
拓扑极表面积Topological Polar Surface Area 74.600 Ų
重原子数Heavy Atom Count 13
形式电荷Formal Charge 0
复杂度Complexity 147.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 Warning
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激
预防措施声明

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染：用水充分清洗。

P321: 特殊处理（请参阅此标签上的...）。

P264: 处理后要彻底洗手。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。
WGK Germany 1
RTECS CM1980000
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

 SDS英文版

质量标准

Melting point 102-105（℃）
Purity(GC) 85-100（%）
Appearance（A108440) White to off-white solid
Infrared spectrum Conforms to Structure

 质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到6个结果

批号(Lot Number) 证书类型 日期 货号
J2312104 分析证书 23-10-19 A108440
E2331185 分析证书 23-06-09 A108440
J2210130 分析证书 22-10-12 A108440
G1430043 分析证书 22-06-20 A108440
B2303906 分析证书 21-11-11 A108440
E2311097 分析证书 21-11-11 A108440

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参考文献

1. A Fitton,K L Goa.  (1991-05-01)  Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders..  Drugs,  41  ((5)): (780-798).  [PMID:1712709]
2. G Hoffmann,S Aramaki,E Blum-Hoffmann,W L Nyhan,L Sweetman.  (1989-04-01)  Quantitative analysis for organic acids in biological samples: batch isolation followed by gas chromatographic-mass spectrometric analysis..  Clinical chemistry,  35  ((4)): (587-595).  [PMID:2702744]
3. K U Schallreuter,J M Wood.  (1987-09-01)  Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells..  Cancer letters,  36  ((3)): (297-305).  [PMID:3652030]
4. Q H Nguyen,T P Bui.  (1995-02-01)  Azelaic acid: pharmacokinetic and pharmacodynamic properties and its therapeutic role in hyperpigmentary disorders and acne..  International journal of dermatology,  34  ((2)): (75-84).  [PMID:7737781]
5. F Guneral,C Bachmann.  (1994-06-01)  Age-related reference values for urinary organic acids in a healthy Turkish pediatric population..  Clinical chemistry,  40  ((6)): (862-866).  [PMID:8087979]
6. J Brasch,E Christophers.  (1993-01-01)  Azelaic acid has antimycotic properties in vitro..  Dermatology (Basel, Switzerland),  186  ((1)): (55-58).  [PMID:8435518]
7. K Graupe,W J Cunliffe,H P Gollnick,R P Zaumseil.  (1996-01-01)  Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports..  Cutis,  57  ((1 Suppl)): (20-35).  [PMID:8654128]
8. A S Breathnach.  (1996-01-01)  Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies..  Cutis,  57  ((1 Suppl)): (36-45).  [PMID:8654129]
9. P S Mackrides,A F Shaughnessy.  (1996-12-01)  Azelaic acid therapy for acne..  American family physician,  54  ((8)): (2457-2459).  [PMID:8961845]
10.  (1993-06-21)  Azelaic acid--a new topical treatment for acne..  Drug and therapeutics bulletin,  31  ((13)): (50-52).  [PMID:8344141]
11. G F Hoffmann,W Meier-Augenstein,S Stöckler,R Surtees,D Rating,W L Nyhan.  (1993-01-01)  Physiology and pathophysiology of organic acids in cerebrospinal fluid..  Journal of inherited metabolic disease,  16  ((4)): (648-669).  [PMID:8412012]
12. V Rocamora,L Puig,J Romaní,J M de Moragas.  (1999-08-04)  Amelanotic lentigo maligna melanoma: report of a case and review of the literature..  Cutis,  64  ((1)): (53-56).  [PMID:10431675]
13. J J Russell.  (2000-02-12)  Topical therapy for acne..  American family physician,  61  ((2)): (357-366).  [PMID:10670502]
14. S H Korman,H Mandel,A Gutman.  (2000-07-15)  Characteristic urine organic acid profile in peroxisomal biogenesis disorders..  Journal of inherited metabolic disease,  23  ((4)): (425-428).  [PMID:10896310]
15. G Webster.  (2000-07-18)  Combination azelaic acid therapy for acne vulgaris..  Journal of the American Academy of Dermatology,  43  ((2 Pt 3)): (S47-S50).  [PMID:10898830]
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17. James Q Del Rosso.  (2002-12-10)  A status report on the medical management of rosacea: focus on topical therapies..  Cutis,  70  ((5)): (271-275).  [PMID:12469780]
18. Montserrat Morillas,Paulino Gómez-Puertas,Assia Bentebibel,Eva Sellés,Nuria Casals,Alfonso Valencia,Fausto G Hegardt,Guillermina Asins,Dolors Serra.  (2002-12-25)  Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition..  The Journal of biological chemistry,  278  ((11)): (9058-9063).  [PMID:12499375]
19. David C Liao.  (2003-01-24)  Management of acne..  The Journal of family practice,  52  ((1)): (43-51).  [PMID:12540312]
20. James Q Del Rosso.  (2003-12-19)  Medical treatment of rosacea with emphasis on topical therapies..  Expert opinion on pharmacotherapy,  5  ((1)): (5-13).  [PMID:14680431]
21. James E Frampton,Antona J Wagstaff.  (2004-02-26)  Azelaic acid 15% gel: in the treatment of papulopustular rosacea..  American journal of clinical dermatology,  5  ((1)): (57-64).  [PMID:14979745]
22. Rebat M Halder,Georgianna M Richards.  (2004-04-29)  Management of dyschromias in ethnic skin..  Dermatologic therapy,  17  ((2)): (151-157).  [PMID:15113282]
23. R M Halder,G M Richards.  (2004-08-31)  Topical agents used in the management of hyperpigmentation..  Skin therapy letter,  9  ((6)): (1-3).  [PMID:15334278]
24. Karol Burkhart Lindow.  (2004-12-24)  Rosacea. An overview of diagnosis and management..  Advance for nurse practitioners,  12  ((12)): (27-32).  [PMID:15615217]
25. Kimberly A Cayce,Amy J McMichael,Steven R Feldman.  (2004-12-31)  Hyperpigmentation: an overview of the common afflictions..  Dermatology nursing,  16  ((5)): (401-406).  [PMID:15624705]
26. John E Wolf.  (2005-04-07)  Present and future rosacea therapy..  Cutis,  75  ((3 Suppl)): (4-7).  [PMID:15810803]
27. Esther J van Zuuren,Mark A Graber.  (2005-04-07)  The rigor of trials evaluating Rosacea treatments..  Cutis,  75  ((3 Suppl)): (13-16).  [PMID:15810805]
28. Sarah Purdy.  (2005-09-02)  Acne vulgaris..  Clinical evidence,  ((13)(13)): (2038-2059).  [PMID:16135322]
29. Heather L Roebuck.  (2005-09-10)  Face up to rosacea..  The Nurse practitioner,  30  ((9)): (24-30).  [PMID:16151303]
30. Valerie D Callender.  (2005-09-17)  Considerations for treating acne in ethnic skin..  Cutis,  76  ((2 Suppl)): (19-23).  [PMID:16164153]
31. Jennie B Nally,Diane S Berson.  (2006-02-14)  Topical therapies for rosacea..  Journal of drugs in dermatology : JDD,  5  ((1)): (23-26).  [PMID:16468288]
32. Zoe Diana Draelos.  (2006-03-29)  The rationale for advancing the formulation of azelaic acid vehicles..  Cutis,  77  ((2 Suppl)): (7-11).  [PMID:16566282]
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