XAV 939

XAV 939 synthesized to cGMP guidelines

有货

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货号 (SKU)	包装规格	是否现货	价格	数量
X753399-GMP-10mg	10mg	期货

基本描述

英文别名	3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
规格或纯度	GMP, ≥99%
英文名称	XAV 939
储存温度	室温
运输条件	常规运输
产品介绍	Tankyrase Inhibitor; inhibits WNT signaling. Promotes cardiomyocyte differentiation from ESCs

分子类型	小分子
IUPAC Name	2-[4-(trifluoromethyl)phenyl]-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one
INCHI	InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
InChi Key	KLGQSVMIPOVQAX-UHFFFAOYSA-N
Canonical SMILES	C1CSCC2=C1N=C(NC2=O)C3=CC=C(C=C3)C(F)(F)F
Isomeric SMILES	C1CSCC2=C1N=C(NC2=O)C3=CC=C(C=C3)C(F)(F)F
WGK Germany	3
PubChem CID	135418940
分子量	312.31

分子量	312.310 g/mol
XLogP3	2.300
氢键供体数Hydrogen Bond Donor Count	1
氢键受体数Hydrogen Bond Acceptor Count	6
可旋转键计数Rotatable Bond Count	1
精确质量Exact Mass	312.054 Da
单同位素质量Monoisotopic Mass	312.054 Da
拓扑极表面积Topological Polar Surface Area	66.800 Å²
重原子数Heavy Atom Count	21
形式电荷Formal Charge	0
复杂度Complexity	505.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

象形图	GHS06, GHS07
信号词	Danger
危险声明	H319: 引起严重眼睛刺激 H301: 吞咽会中毒
预防措施声明	P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。
WGK Germany	3

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

1. Xin Wang, Shoulin Li, Cheng Zhang, Wenping Xu, Mengqi Wu, Jiagao Cheng, Zhong Li, Liming Tao, Yang Zhang. (2024) Stereoselective toxicity of acetochlor chiral isomers on the nervous system of zebrafish larvae. JOURNAL OF HAZARDOUS MATERIALS, 464 (133016). [PMID:37992503] [10.1016/j.jhazmat.2023.133016]
2. Yuan Xu, Jian He, Jun He. (2022) Cyanidin attenuates the high hydrostatic pressure-induced degradation of cellular matrix of nucleus pulposus cell via blocking the Wnt/β-catenin signaling. TISSUE & CELL, 76 (101798). [PMID:35472676] [10.1016/j.tice.2022.101798]
3. Chen Gang, Chen Weicheng, Ye Ming, Tan Weiqiang, Jia Bing. (2019) TRIM59 knockdown inhibits cell proliferation by down-regulating the Wnt/β-catenin signaling pathway in neuroblastoma. BIOSCIENCE REPORTS, 39 (1): [PMID:30389710] [10.1042/BSR20181277]

1. Xin Wang, Shoulin Li, Cheng Zhang, Wenping Xu, Mengqi Wu, Jiagao Cheng, Zhong Li, Liming Tao, Yang Zhang. (2024) Stereoselective toxicity of acetochlor chiral isomers on the nervous system of zebrafish larvae. JOURNAL OF HAZARDOUS MATERIALS, 464 (133016). [PMID:37992503] [10.1016/j.jhazmat.2023.133016]
2. Yuan Xu, Jian He, Jun He. (2022) Cyanidin attenuates the high hydrostatic pressure-induced degradation of cellular matrix of nucleus pulposus cell via blocking the Wnt/β-catenin signaling. TISSUE & CELL, 76 (101798). [PMID:35472676] [10.1016/j.tice.2022.101798]
3. Chen Gang, Chen Weicheng, Ye Ming, Tan Weiqiang, Jia Bing. (2019) TRIM59 knockdown inhibits cell proliferation by down-regulating the Wnt/β-catenin signaling pathway in neuroblastoma. BIOSCIENCE REPORTS, 39 (1): [PMID:30389710] [10.1042/BSR20181277]