| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| V424374-1ml |
1ml |
现货  |
|
| 别名 | 沃替西汀 | 沃替西汀 |
|---|---|
| 英文别名 | Lu AA 21004 | AR-270/43507985 | GG-0052 | Lu AA 21004 | Piperazine, 1-[2-[(2,4-dimethylphenyl)thio]phenyl]-; 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine; Lu AA 21004; Vortioxetine | VORTIOXETINE [INN] | FS-3517 | 1-[2-(2,4-dimethylphenylsulfanyl)ph |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Vortioxetine |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 5-HT 1A 受体激动剂；5-HT 1B 受体激动剂；5-HT 1D 受体拮抗剂；5-HT 2A 受体拮抗剂；5-HT 3A 受体拮抗剂；5-HT 5A 受体拮抗剂；5-HT 6 受体拮抗剂；5-HT 7 受体拮抗剂；SERT 抑制剂 |
| 产品介绍 |
Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively. IC50 Value: 15nM (5-HT1A); 33nM (5-HT1B); 3.7nM(5-HT3A); 19nM (5-HT7); 1.6 nM(SERT) Target: 5-HT receptor Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively. IC50 Value: 15nM (5-HT1A); 33nM (5-HT1B); 3.7nM(5-HT3A); 19nM (5-HT7); 1.6 nM(SERT) Target: 5-HT receptor |
| EC号 | 823-919-6 |
|---|---|
| 分子类型 | 小分子 |
| IUPAC Name | 1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine |
| INCHI | InChI=1S/C18H22N2S/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20/h3-8,13,19H,9-12H2,1-2H3 |
| InChi Key | YQNWZWMKLDQSAC-UHFFFAOYSA-N |
| Canonical SMILES | CC1=CC(=C(C=C1)SC2=CC=CC=C2N3CCNCC3)C |
| Isomeric SMILES | CC1=CC(=C(C=C1)SC2=CC=CC=C2N3CCNCC3)C |
| 关联CAS | 508233-74-7 |
| PubChem CID | 9966051 |
| MeSH Entry Terms | 1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine;brintellix;Lu AA21004;Lu-AA21004;LuAA21004;vortioxetine;vortioxetine hydrobromide |
| 分子量 | 298.45 |
| 分子量 | 298.400 g/mol |
|---|---|
| XLogP3 | 4.200 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 298.15 Da |
| 单同位素质量Monoisotopic Mass | 298.15 Da |
| 拓扑极表面积Topological Polar Surface Area | 40.600 Ų |
| 重原子数Heavy Atom Count | 21 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 316.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS08 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H373: 通过长时间或反复暴露对器官造成损害 H361: 怀疑破坏生育力或未出生的孩子 H371: 可能会损坏器官 |
| 预防措施声明 |
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。 P308+P316: 如果暴露或担心：立即寻求紧急医疗救助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| Concentration(Compounding value) | 9.0-11.0(mmol/L) |
|---|---|
| Record the entire process by video | Conform |
| 1. Yunong Li, Haixia Zhu, Jingbo Yang, Kehui Ke, Yanmei Zhu, Li Chen, Youyang Qu, Rui Suo, Xiujie Chen, Yulan Zhu. (2019) Discovering Proangiogenic Drugs in Ischemic Stroke Based on the Relationship between Protein Domain and Drug Substructure. ACS Chemical Neuroscience, 10 (1): (507–517). [PMID:30346717] [10.1021/acschemneuro.8b00381] |
| 1. Yunong Li, Haixia Zhu, Jingbo Yang, Kehui Ke, Yanmei Zhu, Li Chen, Youyang Qu, Rui Suo, Xiujie Chen, Yulan Zhu. (2019) Discovering Proangiogenic Drugs in Ischemic Stroke Based on the Relationship between Protein Domain and Drug Substructure. ACS Chemical Neuroscience, 10 (1): (507–517). [PMID:30346717] [10.1021/acschemneuro.8b00381] |
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