| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T655584-1ml |
1ml |
期货  |
|
| 别名 | TLR7 激动剂 2 |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | TLR7 agonist 2 |
| 生化机理 | TLR7 激动剂 2 是一种强效的选择性 Toll 样受体 7（TLR7）激动剂，其 LEC 为 0.4 μM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
TLR7 agonist 2 is a potent and selective Toll-like Receptor 7 ( TLR7 ) agonist with a LEC of 0.4 μM. In Vitro TLR7 agonist 2 is a potent and selective Toll-like Receptor 7 (TLR7) agonist with a lowest effective concentration (LEC) of 0.4 μM in HEK293 cell. TLR7 agonist 2 is found to be selective for TLR7 over TLR8 with LEC of >100 μM for human TLR8. TLR7 agonist 2 demonstrates low inhibition across five CYP450 isozymes (IC 50 >10 μM) and is also not a time dependent inhibitor of CYP450 3A4. TLR7 agonist 2 has limited inhibition of the hERG potassium ion channel 3 H-dofetilide binding in vitro (IC 50 >50 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo TLR7 agonist 2 is found to be rapidly cleared in conjunction with our target profile. Both C max and AUC increase less than dose proportionally between 0.3 and 3 mg/kg and more than dose-proportionally between 3 and 10 mg/kg. TLR7 agonist 2 can induce an antiviral interferon stimulated gene (ISG) response without inducing an IFNα response at a low dose. TLR7 agonist 2 also induces a 2.7 log decrease in serum HBV viral load from 0.3 mg/kg, and a maximum 3.1 log decrease is observed for doses between 1 and 5 mg/kg . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:LEC: 0.4 μM (TLR7) |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | CC1=CC(=NO1)COC2=NC(=NC3=C2N(C=C3)CC4=CC=CC=N4)N |
| 分子量 | 336.35 |
首页
400-620-6333
