| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T346139-1mg |
1mg |
期货  |
|
| 英文别名 | Thyroxine glucuronide | (2S,3S,4S,5R)-6-[4-[4-[(2S)-2-Amino-3-Hydroxy-3-Oxo-Propyl]-2,6-Diiodo-Phenoxy]-2,6-Diiodo-Phenoxy]-3,4,5-Trihydroxy-Tetrahydropyran-2-Carboxylic Acid |
|---|---|
| 规格或纯度 | ≥95% |
| 英文名称 | Thyroxine 4'-O-β-D-Glucuronide |
| 储存温度 | 2-8°C储存,充氩 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
甲状腺素4'-O-β-D-葡糖苷酸是甲状腺素的代谢衍生物，旨在探索和阐明甲状腺激素代谢和调节的复杂性。其独特结构结合了葡糖醛酸部分，使其成为研究甲状腺素生物转化过程，特别是其II期代谢的宝贵工具，在此过程中，它经历结合反应，使分子更具水溶性，从而更易于排泄。这种衍生物在专注于了解甲状腺激素分布和消除动态的研究中发挥着关键作用，为理解激素稳态机制和内分泌系统功能的复杂性提供了见解。甲状腺素4'-O-β-D-葡糖苷酸作为模型化合物，有助于开发用于检测和定量激素代谢产物的分析技术，进一步促进我们对甲状腺生理学和调节其生物系统内活性的代谢途径的了解。
Thyroxine 4 ' -O-β-D-glucuronide is a metabolic derivative of thyroxine, which aims to explore and elucidate the complexity of thyroid hormone metabolism and regulation. Its unique structure combines the glucuronic acid part, making it a valuable tool for studying the biotransformation process of thyroxine, especially its phase II metabolism. In this process, it undergoes a binding reaction to make the molecule more water-soluble and thus easier to excrete. This derivative plays a key role in research focused on understanding the dynamics of thyroid hormone distribution and elimination, providing insights into the complexity of hormone homeostasis mechanisms and endocrine system functions. As a model compound, thyroxine 4 ' -O-β-D-glucuronide is helpful to develop analytical techniques for the detection and quantification of hormone metabolites, and further promote our understanding of thyroid physiology and metabolic pathways that regulate the activity of its biological system.
|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | (2S,3S,4S,5R)-6-[4-[4-[(2S)-2-amino-2-carboxyethyl]-2,6-diiodophenoxy]-2,6-diiodophenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid |
| INCHI | InChI=1S/C21H19I4NO10/c22-8-1-6(3-12(26)19(30)31)2-9(23)16(8)34-7-4-10(24)17(11(25)5-7)35-21-15(29)13(27)14(28)18(36-21)20(32)33/h1-2,4-5,12-15,18,21,27-29H,3,26H2,(H,30,31)(H,32,33)/t12-,13-,14-,15+,18-,21?/m0/s1 |
| InChi Key | RGHRJBIKIYUHEV-SGPDEFQSSA-N |
| Canonical SMILES | C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)OC3C(C(C(C(O3)C(=O)O)O)O)O)I)I)CC(C(=O)O)N |
| Isomeric SMILES | C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)OC3[C@@H]([C@H]([C@@H]([C@H](O3)C(=O)O)O)O)O)I)I)C[C@@H](C(=O)O)N |
| 分子量 | 952.99 |
| 敏感性 | 湿度敏感 |
|---|---|
| 熔点 | >169° C (dec.) |
| Purity(HPLC area) | 95-100（%） |
|---|---|
| NMR Spectrum 1H | Conforms to Structure |
| Specific Rotation [a]20/D(c = 0.2, DMSO) | -23.2～-17.2（°） |
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