色胺, 5-HT 1B 受体的激动剂;5-HT 1D 受体的激动剂;5-HT 1e 受体的激动剂;5-HT 1F 受体的激动剂;5-HT 2A 受体的激动剂;5-HT 2B 受体的激动剂;5-HT 2C 受体的激动剂;5-HT 6 受体的激动剂;5-HT 7 受体的激动剂

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货号 (SKU) 包装规格 是否现货 价格 数量
T101154-5g
5g 现货 Stock Image
T101154-25g
25g 现货 Stock Image
T101154-100g
100g 现货 Stock Image
T101154-500g
500g 期货 Stock Image

基本描述

别名 3-(2-氨乙基)吲哚 | β-吲哚基乙胺
英文别名 KBio2_000393 | KBio2_002961 | NINDS_000862 | Oprea1_870097 | SCHEMBL13006684 | Spectrum2_000873 | Spectrum4_000850 | KBioSS_000393 | NCGC00095081-02 | 3-[2-Aminoethyl]indole | CS-D1750 | HMS1922K18 | TSH | (3-Indolyl)ethylamine | NCGC00014994-03 | 2-(1H-I
规格或纯度 Moligand™, ≥98%
英文名称 Tryptamine
生化机理 具有血管活性;可能具有神经调质功能;由色氨酸经 L-芳香氨基酸脱羧酶作用进行脱羧而形成的生物胺。
应用 具有血管活性;可能具有神经调质功能;由色氨酸经 L-芳香氨基酸脱羧酶作用进行脱羧而形成的生物胺。
储存温度 2-8°C储存,避光,充氩
运输条件 冰袋运输
作用类型 激动剂
作用机制 5-HT 1B 受体的激动剂;5-HT 1D 受体的激动剂;5-HT 1e 受体的激动剂;5-HT 1F 受体的激动剂;5-HT 2A 受体的激动剂;5-HT 2B 受体的激动剂;5-HT 2C 受体的激动剂;5-HT 6 受体的激动剂;5-HT 7 受体的激动剂
产品介绍

具有血管活性;可能具有神经调质功能;由色氨酸经 L-芳香氨基酸脱羧酶作用进行脱羧而形成的生物胺。

Tryptamine was used in: multi-layered analysis, used to differentiate and identify biogenic amines; in the synthesis of indole ring-terminated thiol, ω-mercaptooctyltryptamide; in surface-enhanced Raman spectroscopic investigation of indole ring-terminated self-assembled monolayer on gold electrode;

关联靶点(人)

MPO Tchem 髓过氧化物酶(Myeloperoxidase) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR1B Tclin 5-羟色胺受体 1B(5-hydroxytryptamine receptor 1B) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR2A Tclin 5-羟色胺受体 2A(5-hydroxytryptamine receptor 2A) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR1E Tchem 5-羟色胺受体 1E(5-hydroxytryptamine receptor 1E) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR7 Tclin 5-羟色胺受体 7(5-hydroxytryptamine receptor 7) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR1D Tclin 5-羟色胺受体 1D(5-hydroxytryptamine receptor 1D) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR1F Tclin 5-羟色胺受体 1F(5-hydroxytryptamine receptor 1F) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR2C Tclin 5-羟色胺受体 2C(5-hydroxytryptamine receptor 2C) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR6 Tchem 5-羟色胺受体 6(5-hydroxytryptamine receptor 6) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR2B Tclin 5-羟色胺受体 2B(5-hydroxytryptamine receptor 2B) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1D Tclin Serotonin 1d (5-HT1d) receptor (2897 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CTSK Tchem Cathepsin K (3011 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MPO Tchem Myeloperoxidase (1002 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR6 Tchem Serotonin 6 (5-HT6) receptor (9749 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2A6 Tchem Cytochrome P450 2A6 (2861 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HT-1080 (3966 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MCF7 (126967 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
WI-38 (2654 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
A549 (127892 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HCT-116 (91556 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HEK293 (82097 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HepG2 (196354 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
IDO1 Tchem Indoleamine 2,3-dioxygenase (6650 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MBNL1 Tbio Muscleblind-like protein 1 (34431 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2A13 Tchem Cytochrome P450 2A13 (65 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点(其它种属)

Htr7 Serotonin 7 (5-HT7) receptor (19 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
tat Human immunodeficiency virus type 1 Tat protein (75 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Bacillus subtilis (32866 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Saccharomyces cerevisiae (19171 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plenodomus lingam (178 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NIH3T3 (5395 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Taar1 Trace amine-associated receptor 1 (899 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
STR1 Strictosidine synthase (9 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ftmPT1 Brevianamide F prenyltransferase (40 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Adra2c Adrenergic receptor alpha-2 (3313 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Htr2b Serotonin 2 (5-HT2) receptor (2078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 200-510-5
分子类型 小分子
IUPAC Name 2-(1H-indol-3-yl)ethanamine
INCHI InChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2
InChi Key APJYDQYYACXCRM-UHFFFAOYSA-N
Canonical SMILES C1=CC=C2C(=C1)C(=CN2)CCN
Isomeric SMILES C1=CC=C2C(=C1)C(=CN2)CCN
WGK Germany 3
RTECS NL4020000
PubChem CID 1150
分子量 160.22
Beilstein号 125513
Reaxy-Rn 125513

化学和物理性质

溶解性 Soluble in DMSO, Methanol. Insoluble in water.
密度 1.157
敏感性 对热和空气敏感;对光敏感
闪点(℉) 365 °F
闪点(℃) 185℃
沸点 137 °C/0.15 mmHg (lit.)
熔点 113-117°C
分子量 160.220 g/mol
XLogP3 1.600
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 1
可旋转键计数Rotatable Bond Count 2
精确质量Exact Mass 160.1 Da
单同位素质量Monoisotopic Mass 160.1 Da
拓扑极表面积Topological Polar Surface Area 41.800 Ų
重原子数Heavy Atom Count 12
形式电荷Formal Charge 0
复杂度Complexity 147.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性(GHS)

象形图 GHS07
信号词 Warning
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激

预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染:用水充分清洗。

P321: 特殊处理(请参阅此标签上的...)。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P271: 仅在室外或通风良好的地方使用。

P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。

P403+P233: 存放在通风良好的地方。保持容器密闭。

P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续:寻求医疗帮助。

P332+P317: 如果出现皮肤刺激:请寻求医疗帮助。

P319: 如果你感到不适,请寻求医疗帮助。

WGK Germany 3
RTECS NL4020000
Reaxy-Rn 125513
Merck Index 9796
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

质量标准

Purity(HPLC) 98-100(%)
Melting point 115-118(℃)
Purity(Titration by HClO4) 97.5-102.5(%)
Water by Karl Fischer 0-2(%)
Appearance(T101154) White to Yellow to Tan Powder,Flakes or Solid
Infrared spectrum Conforms to Structure
Proton NMR spectrum Conforms to Structure
Solubility in MeOH almost transparency

质检证书(CoA,COO,BSE/TSE 和分析图谱)

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批号(Lot Number) 证书类型 日期 货号
E2422121 分析证书 24-05-24 T101154
K2328093 分析证书 23-12-07 T101154
J2311098 分析证书 23-10-16 T101154
C2010129 分析证书 22-01-26 T101154
A2213596 分析证书 21-12-29 T101154
A2213580 分析证书 21-12-29 T101154
A2213591 分析证书 21-12-29 T101154
A2214062 分析证书 21-12-29 T101154
L2417169 分析证书 21-12-29 T101154
C2511164 分析证书 21-12-29 T101154
C2513149 分析证书 21-12-29 T101154

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此产品的引用文献

1. Jian-Jun Zhong,Ningbo Liao,Tian Ding,Xingqian Ye,Dong-Hong Liu.  (2015-07-05)  Liquid chromatographic method for toxic biogenic amines in foods using a chaotropic salt..  Journal of chromatography. A,  1406  (331-336).  [PMID:26141272]
2. Yiting Xu, Xiaobo Yu, Meiling Chen, Yi Sun, Wei Zhang, Yajin Fang, Lanyun Fang, Haining Na, Fei Liu, Jin Zhu.  (2023)  Dual responsive cellulose-based fluorescent material fabricated in a CO2 switchable solvent for multifunctional applications.  CHEMICAL ENGINEERING JOURNAL,  477  (147272).  [10.1016/j.cej.2023.147272]
3. Shikai Zhang, Qing Xu, Changbo Ji, Xiaoyu Han, Yang Zhou, Chao Liang, Linran Ma, Weijian Sun, Yanling Li, Zhengyou Yang, Fengchun Zhao, Yuan Tian.  (2023)  Study on secondary metabolites of endophytic fungus Diaporthe sp. AC1 induced by tryptophan analogs.  Frontiers in Microbiology,  14  (1254609).  [PMID:37876783] [10.3389/fmicb.2023.1254609]
4. Junjun Wang, Yue Tang, Jia Zheng, Zhengmin Xie, Jianli Zhou, Yuangen Wu.  (2024)  DNAzyme-based and smartphone-assisted colorimetric biosensor for ultrasensitive and highly selective detection of histamine in meats.  FOOD CHEMISTRY,  435  (137526).  [PMID:37742463] [10.1016/j.foodchem.2023.137526]
5. Zekun Shi, Yongning Wu, Xue Zhang, Yanyan Gao, Luqin Qiao, Qin Hou, Minglin Wang.  (2023)  Highly sensitive and selective colorimetric and fluorescent dual-readout assay for the analysis of spermine, spermidine and cysteine.  DYES AND PIGMENTS,  220  (111659).  [10.1016/j.dyepig.2023.111659]
6. Pan Hu, Xin Yan, Yijia Zeng, Zherui Jiang, Juan Liu, Wu-wen Feng.  (2023)  An UPLC-MS/MS method for targeted analysis of microbial and host tryptophan metabolism after administration of polysaccharides from Atractylodes macrocephala Koidz. in ulcerative colitis mice.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  235  (115585).  [PMID:37523866] [10.1016/j.jpba.2023.115585]
7. Lin Pang, Tianshi Zhang, Yuan Liu, Dezhong Li, Jiguang Li, Ming Guan, Xincun Dou.  (2023)  Dual noncovalent interaction facilitated highly sensitive and specific colorimetric–fluorescent sensing for tryptamines.  SENSORS AND ACTUATORS B-CHEMICAL,  391  (134061).  [10.1016/j.snb.2023.134061]
8. Qixing Nie, Yonggan Sun, Mingzhi Li, Sheng Zuo, Chunhua Chen, Qiongni Lin, Shaoping Nie.  (2023)  Targeted modification of gut microbiota and related metabolites via dietary fiber.  CARBOHYDRATE POLYMERS,  316  (120986).  [PMID:37321707] [10.1016/j.carbpol.2023.120986]
9. Nuo Duan, Kexin Ren, Mingqian Song, Xinyue Zhang, Zhouping Wang, Fei Jia, Shijia Wu.  (2023)  A dual-donor FRET based aptamer sensor for simultaneous determination of histamine and tyramine in fishes.  MICROCHEMICAL JOURNAL,  191  (108801).  [10.1016/j.microc.2023.108801]
10. Shuyuan Cao, Shengjie Hu, Ping Jiang, Zhan Zhang, Lei Li, Qian Wu.  (2023)  Effects of sulforaphane on breast cancer based on metabolome and microbiome.  Food Science & Nutrition,  11  (5): (2277-2287).  [PMID:37181316] [10.1002/fsn3.3168]
11. Xu Yanfen, Lu Ying, Yu Jianna, Liu Wen, Jing Guoxing, Li Wenshan, Liu Wenjie.  (2023)  Determination of Seven Biogenic Amines in Tuna with High-Performance Liquid Chromatography Coupled to Electrospray Ionization Ion Mobility Spectrometry.  Food Analytical Methods,  16  (5): (909-917).  [10.1007/s12161-023-02455-y]
12. Yuze Li, Ke Jia, Yixin Pan, Jing Han, Junyu Chen, Yiran Wang, Xiaobing Ma, Hongwei Chen, Shengjie Wang, Dongcheng Xie, Caiqiao Xiong, Zongxiu Nie.  (2023)  Pocket-Size Wireless Nanoelectrospray Ionization Mass Spectrometry for Metabolic Analysis of Salty Biofluids and Single Cells.  ANALYTICAL CHEMISTRY,  95  (10): (4612–4618).  [PMID:36862115] [10.1021/acs.analchem.2c04268]
13. Si Lin, Hou Juying, Lv Wei, Hou Qin, Xu Zhixiang, Ai Shiyun.  (2023)  An intelligent fluorescence platform based on lignocellulose components and fluorescein for food freshness monitoring.  Biomass Conversion and Biorefinery,  (1-11).  [10.1007/s13399-023-03879-6]
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