| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S613473-5mg |
5mg |
期货  |
| |
| S613473-25mg |
25mg |
期货 |
|
| 别名 | compound 20;SBP 3264;SBP3264 |
|---|---|
| 英文别名 | compound 20;SBP 3264;SBP3264 |
| 规格或纯度 | Moligand™ |
| 英文名称 | SBP-3264 |
| 作用类型 | 抑制剂 |
| 作用机制 | 丝氨酸/苏氨酸激酶 3 抑制剂；丝氨酸/苏氨酸激酶 4 抑制剂 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 未知 |
|---|---|
| INCHI | InChI=1S/C19H20ClN5O/c1-12(26)24-15-5-7-25(8-6-15)19-17-16(10-21-18(17)22-11-23-19)13-3-2-4-14(20)9-13/h2-4,9-11,15H,5-8H2,1H3,(H,24,26)(H,21,22,23) |
| InChi Key | AYRVYPOFYQSRNH-UHFFFAOYSA-N |
| Canonical SMILES | Clc1cccc(c2c[nH]c3ncnc(N4CCC(NC(=O)C)CC4)c23)c1 |
| Isomeric SMILES | CC(=O)NC1CCN(CC1)C2=NC=NC3=C2C(=CN3)C4=CC(=CC=C4)Cl |
| PubChem CID | 162366980 |
| 1. Cottini F, Hideshima T, Xu C, Sattler M, Dori M, Agnelli L, ten Hacken E, Bertilaccio MT, Antonini E, Neri A et al.. (2014) Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers.. Nat Med, 20 (6): (599-606). [PMID:24813251] |
| 2. Wermke M, Camgoz A, Paszkowski-Rogacz M, Thieme S, von Bonin M, Dahl A, Platzbecker U, Theis M, Ehninger G, Brenner S et al.. (2015) RNAi profiling of primary human AML cells identifies ROCK1 as a therapeutic target and nominates fasudil as an antileukemic drug.. Blood, 125 (24): (3760-8). [PMID:25931586] |
| 3. Camgoz A, Paszkowski-Rogacz M, Satpathy S, Wermke M, Hamann MV, von Bonin M, Choudhary C, Knapp S, Buchholz F. (2018) STK3 is a therapeutic target for a subset of acute myeloid leukemias.. Oncotarget, 9 (39): (25458-25473). [PMID:29876001] |
| 4. Bata N, Chaikuad A, Bakas NA, Limpert AS, Lambert LJ, Sheffler DJ, Berger LM, Liu G, Yuan C, Wang L et al.. (2021) Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia.. J Med Chem, [PMID:34807584] [10.1021/acs.jmedchem.1c00804] |
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