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糖精, TAS2R31 的激动剂;TAS2R43 的激动剂

25篇引用文献
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货号 (SKU) 包装规格 是否现货 价格 数量
S112429-25g
 25g 现货 Stock Image
S112429-100g
 100g 现货 Stock Image
S112429-500g
 500g 现货 Stock Image
S112429-2.5kg
 2.5kg 现货 Stock Image
大包装询价 收藏夹 比较  SDS中文版  DATASHEET
查看相关系列
TAS2R31 Agonist (3) TAS2R43 Agonist (7)
main product photo

基本描述

别名 邻磺酰苯甲酰亚胺 | 邻苯甲硫酰亚胺 | 2-磺基苯甲酸亚胺 | 2,3-二羟基-1,2-苯并异噻唑基-3-酮-1,1-二氧化物 | 邻苯甲硫酰亚胺 | 2,3-二羟基-1,2-苯并异噻唑基-3-酮-1,1-二氧化物 | 2-磺基苯甲酸亚胺
英文别名 AI3-38107 | 1,1-Dioxide-1,2-benzisothiazolin-3-one | HSDB 669 | 1,2-Dihydro-2-ketobenzisosulphonazole | Benzosulfinide | 3-Hydroxybenzisothiazole-S,S-dioxide | Anhydro-o-sulfaminebenzoic acid | o-Benzoic sulfimide | Benzo-sulphinide | Kristallose | SACCHA
规格或纯度 Moligand™, ≥98%
英文名称 Saccharin
生化机理 一种非营养性甜味剂和一种制药辅助剂（香精）。糖精曾被列为合理预期的人类致癌物，但由于癌症数据不足以满足当前的列名标准，因此已被除名。
储存温度 充氩
运输条件 常规运输
作用类型 激动剂
作用机制 TAS2R31 的激动剂;TAS2R43 的激动剂
产品介绍

Usually used in high performance liquid chromatographic method for the simultaneous separation and determination of acesulfame potassium, saccharine and aspartame;and also used in sweet preference test of rats.

Usually used in high performance liquid chromatographic method for the simultaneous separation and determination of acesulfame potassium, saccharine and aspartame;and also used in sweet preference test of rats.

关联靶点（人）

TAS2R43 Tchem 2 型味觉受体成员 43(Taste receptor type 2 member 43) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA6 Tclin 碳酸酐酶6(Carbonic anhydrase 6) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA12 Tclin 碳酸酐酶12(Carbonic anhydrase 12) (8 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA14 Tclin 碳酸酐酶14(Carbonic anhydrase 14) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA9 Tclin 碳酸酐酶9(Carbonic anhydrase 9) (10 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA7 Tclin 碳酸酐酶7(Carbonic anhydrase 7) (3 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
TAS2R31 Tchem 2 型味觉受体成员 31(Taste receptor type 2 member 31) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA2 Tclin Carbonic anhydrase II (17698 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
VDR Tclin Vitamin D receptor (26531 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
THRB Tclin Thyroid hormone receptor beta-1 (7926 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA3 Tclin Carbonic anhydrase III (753 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA6 Tclin Carbonic anhydrase VI (993 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA1 Tclin Carbonic anhydrase I (13240 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BCHE Tclin Butyrylcholinesterase (7174 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
APP Tclin Amyloid-beta A4 protein (8510 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA5B Tclin Carbonic anhydrase VB (957 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA5A Tclin Carbonic anhydrase VA (1168 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA14 Tclin Carbonic anhydrase XIV (1305 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FBP1 Tchem Fructose-1,6-bisphosphatase (1199 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA12 Tclin Carbonic anhydrase XII (6231 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA9 Tclin Carbonic anhydrase IX (8255 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Homo sapiens (32628 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PRMT1 Tchem Protein-arginine N-methyltransferase 1 (867 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Liver (3974 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
USP2 Tbio Ubiquitin carboxyl-terminal hydrolase 2 (8818 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KMT2A Tchem Histone-lysine N-methyltransferase MLL (17327 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TAS2R31 Tchem Taste receptor type 2 member 31 (86 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TAS1R3 Tbio T1R1/T1R3 (473 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Ca7 Carbonic anhydrase VII (3 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA4 Carbonic anhydrase IV (1713 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Carbonic anhydrase (69 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
mtcA1 Uncharacterized protein Rv1284/MT1322 (182 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasma (328 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rmtA RmtA (95 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA Alpha carbonic anhydrase (93 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Astrosclerin-3 (80 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ca1 Delta carbonic anhydrase (40 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
1272966 AGAP002992-PA (40 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Carbonic anhydrase, alpha family (44 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Carbonate dehydratase (40 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 201-321-0, 228-971-8
分子类型 小分子
IUPAC Name 1,1-dioxo-1,2-benzothiazol-3-one
INCHI InChI=1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
InChi Key CVHZOJJKTDOEJC-UHFFFAOYSA-N
Canonical SMILES C1=CC=C2C(=C1)C(=O)NS2(=O)=O
Isomeric SMILES C1=CC=C2C(=C1)C(=O)NS2(=O)=O
WGK Germany 2
RTECS DE4200000
关联CAS 128-44-9,6381-61-9,81-07-2
PubChem CID 5143
NSC Number 5349
MeSH Entry Terms Calcium, Saccharin;Saccharin;Saccharin Calcium;Saccharin Sodium
分子量 183.18
Beilstein号 6888
Reaxy-Rn 6888

化学和物理性质

溶解性 Soluble in water (3.3 g/L at 20°C).
密度 1.557
敏感性 对湿度敏感
熔点 229°C
分子量 183.190 g/mol
XLogP3 0.900
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 3
可旋转键计数Rotatable Bond Count 0
精确质量Exact Mass 182.999 Da
单同位素质量Monoisotopic Mass 182.999 Da
拓扑极表面积Topological Polar Surface Area 71.600 Ų
重原子数Heavy Atom Count 12
形式电荷Formal Charge 0
复杂度Complexity 303.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

WGK Germany 2
RTECS DE4200000
Reaxy-Rn 6888
Merck Index 8311
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

 SDS英文版

质量标准

Purity(HPLC) 98-100（%）
Purity (Titration by NaOH) 98-102（%）
Melting point 226-233（℃）
Appearance（S112429) White Powder or Crystals
Infrared spectrum Conforms to Structure

 质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

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找到18个结果

批号(Lot Number) 证书类型 日期 货号
E2514433 分析证书 25-04-27 S112429
E2514488 分析证书 25-04-27 S112429
C2525478 分析证书 24-07-09 S112429
C2525785 分析证书 24-07-09 S112429
C2525789 分析证书 24-07-09 S112429
L2322247 分析证书 23-12-12 S112429
L2322238 分析证书 23-12-12 S112429
L2322248 分析证书 23-12-12 S112429
L2322249 分析证书 23-12-12 S112429
C2313028 分析证书 23-02-16 S112429
C2313033 分析证书 23-02-16 S112429
C2313034 分析证书 23-02-16 S112429
C2313035 分析证书 23-02-16 S112429
J2330038 分析证书 23-02-16 S112429
C2228007 分析证书 22-02-23 S112429
C2228010 分析证书 22-02-23 S112429
C2228017 分析证书 22-02-23 S112429
C2228041 分析证书 22-02-23 S112429

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参考文献

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