Recombinant Human DDR1 Protein

功能和特点
  • 表达系统: HEK293
  • Accession #: Q08345
  • 蛋白标签: C-His
  • 生物活性: Testing in progress
  • 内毒素水平: <1.0 EU/μg
有货

库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
rp169564-10μg
10μg 现货 Stock Image
rp169564-50μg
50μg 现货 Stock Image
rp169564-100μg
100μg 现货 Stock Image
rp169564-1mg
1mg 期货 Stock Image

基本描述

产品名称 Recombinant Human DDR1 Protein
别名 重组人DDR1蛋白 | 重组人类 DDR1 蛋白
英文别名 CAK | CD167 antigen-like family member A | CD167a antigen | CD167a | DDR | DDR1 | discoidin domain receptor family, member 1 | discoidin domain receptor tyrosine kinase 1 | Discoidin receptor tyrosine kinase | EC 2.7.10 | EC 2.7.10.1 | EDDR1 | ENTRK4 | Ep
规格或纯度 Carrier Free, Animal Free, ≥95%(SDS-PAGE)
产品介绍


Purity: ≥95%, by SDS-PAGE visualized with Coomassie® Blue Staining.
Description:
Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.

生物活性 Testing in progress
内毒素水平 <1.0 EU/μg
表达系统 HEK293
种属 人(Human)
氨基酸 1-416 aa
序列 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTHHHHHH
蛋白标签 C-His
无载体 Yes
无动物源 Yes
Accession # Q08345
来源 重组表达
预测分子量 50.0 kDa
SDS-PAGE 50.9-64.9 kDa, reducing conditions; 47.8-61.2 kDa, non-reducing conditions.

图片

Recombinant Human DDR1 Protein (rp169564) - SDS-PAGE
3 μg/lane of Recombinant Human DDR1 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 50.9-64.9 kDa under reducing conditions and 47.8-61.2 kDa under non-reducing conditions.

产品规格参数

物理形态 冻干(Lyophilized)
储存缓冲液 Lyophilized from PBS, pH7.4
复溶 We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -20°C 下可保存 1 年。避免冷冻/解冻循环。
分子类型 蛋白质

安全和危险性(GHS)

质量标准

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批号(Lot Number) 证书类型 日期 货号
ZJ24F0606441 分析证书 24-06-07 rp169564

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