| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| rp149312-10μg |
10μg |
现货  |
| |
| rp149312-50μg |
50μg |
现货 |
| |
| rp149312-100μg |
100μg |
现货 |
| |
| rp149312-1mg |
1mg |
期货 |
|
| 产品名称 | Recombinant Human NKp30/NCR3 Protein |
|---|---|
| 别名 | 重组人NKp30/NCR3蛋白 | 重组人自然细胞毒性触发受体3蛋白 |
| 英文别名 | Activating natural killer receptor p30 | Natural killer cell p30-related protein | NKp30 | NK-p30 | CD337 antigen | Activating natural killer receptor p30 | CD337 | CD337activating NK-A1 receptor | LY117 | 1C7 | NK-p30 | lymphocyte antigen 117 | natural c |
| 规格或纯度 | ActiBioPure™, 生物活性, 无动物源, Carrier Free, ≥95%(SDS-PAGE) |
| 产品介绍 |
Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation. |
| 生物活性 | Measured by its binding ability in a functional ELISA. When Recombinant Human B7-H6 Fc Chimera is immobilized at 4 µg/mL (100 µL/well), Recombinant Human NKp30/NCR3 His-tag binds with an ED50 of 0.600-7.20 µg/mL. |
| 内毒素水平 | <0.1 EU/μg |
| 表达系统 | HEK293 |
| 种属 | 人(Human) |
| 氨基酸 | 19-138 aa |
| 序列 | LWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVVPGKEVRNGTPEFRGRLAPLASSRFLHDHQAELHIRDVRGHDASIYVCRVEVLGLGVGTGNGTRLVVEKEHPQLGAGTHHHHHH |
| 蛋白标签 | C-His |
| 无载体 | Yes |
| 无动物源 | Yes |
| Accession # | O14931 |
| 来源 | 重组表达 |
| 预测分子量 | 14 kDa |
| SDS-PAGE | 20 - 35 kDa, under reducing conditions; 20 - 35 kDa, under non-reducing conditions. |
Recombinant Human NKp30/NCR3 Protein (rp149312) - SDS-PAGE
3 μg/lane of Recombinant Human NKp30/NCR3 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 20 - 35 kDa.
| 物理形态 | 冻干(Lyophilized) |
|---|---|
| 储存缓冲液 | Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH7.4. |
| 复溶 | Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml. |
| 储存温度 | -20°C储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -20~-80℃ 下可保存 1 年以上。收货后建议分装。避免冷冻/解冻循环。 |
| 分子类型 | 蛋白质 |
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 ZJ24F1215573 |
分析证书 | 24-12-20 | rp149312 |
| ZJ24F1215572 |
分析证书 | 24-12-20 | rp149312 |
| ZJ24F1215571 |
分析证书 | 24-12-20 | rp149312 |
| 1. Nalabolu, S R SR, Shukla, H H, Nallur, G G, Parimoo, S S and Weissman, S M SM.. (1996) Genes in a 220-kb region spanning the TNF cluster in human MHC.. Genomics, (15): [PMID:8824804] |
| 2. Neville, M J MJ and Campbell, R D RD.. (1999) A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:10202016] |
| 3. Pende, D D and 12 more authors.. (1999) Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells.. The Journal of experimental medicine, (15): [PMID:10562324] |
| 4. Xie, Tao T and 7 more authors.. (2003) Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.. Genome research, [PMID:14656967] |
| 5. Vitale, Massimo M and 6 more authors.. (2005) NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor.. Blood, (15): [PMID:15784725] |
| 6. Delahaye, Nicolas F NF, Barbier, Mathieu M, Fumoux, Francis F and Rihet, Pascal P.. (2007) Association analyses of NCR3 polymorphisms with P. falciparum mild malaria.. Microbes and infection, [PMID:17208487] |
| 7. Pogge von Strandmann, Elke E and 12 more authors.. (2007) Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells.. Immunity, [PMID:18055229] |
| 8. Simhadri, Venkateswara Rao VR and 8 more authors.. (2008) Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function.. PloS one, [PMID:18852879] |
| 9. Brandt, Cameron S CS and 14 more authors.. (2009) The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans.. The Journal of experimental medicine, (6): [PMID:19528259] |
| 10. Li, Yili Y, Wang, Qian Q and Mariuzza, Roy A RA.. (2011) Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6.. The Journal of experimental medicine, (11): [PMID:21422170] |
| 11. Joyce, M Gordon MG and 5 more authors.. (2011) Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site.. Proceedings of the National Academy of Sciences of the United States of America, (12): [PMID:21444796] |
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