| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| rp144638-10μg |
10μg |
现货  |
| |
| rp144638-50μg |
50μg |
现货 |
| |
| rp144638-100μg |
100μg |
现货 |
| |
| rp144638-1mg |
1mg |
期货 |
|
| 产品名称 | Recombinant Human Serpin A6 Protein |
|---|---|
| 别名 | 重组人Serpin A6蛋白 | 重组人皮质醇结合球蛋白 | 重组人Serpin A6蛋白 | 重组人皮质醇结合球蛋白 | 重组人Serpin A6蛋白 | 重组人皮质醇结合球蛋白 |
| 英文别名 | CBG | Serpin A6 | Transcortin | (antitrypsin), member 6 | CBG | CBGcorticosteroid-binding globulin | corticosteroid binding globulin | member 6 | serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase | Serpin A6 | serpin peptidase inh |
| 规格或纯度 | 无动物源, 无载体, 生物活性, ActiBioPure™, ≥95%(SDS-PAGE), 见COA |
| 产品介绍 |
Function |
| 生物活性 | Measured by its binding ability in a functional ELISA. When Cortisol-BSA Conjugate is immobilized at 5 μg/mL, 100 μL/well, Recombinant Human Serpin A6 binds with an ED50 of 1.5-7.5 μg/mL. |
| 内毒素水平 | <0.1 EU/μg |
| 表达系统 | HEK293 |
| 种属 | 人(Human) |
| 氨基酸 | 23-405 aa |
| 序列 | MDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPVHHHHHH |
| 蛋白标签 | C-His |
| 无载体 | Yes |
| 无动物源 | Yes |
| Accession # | P08185 |
| 来源 | 重组表达 |
| 预测分子量 | 43 kDa |
| SDS-PAGE | 52 - 73 kDa, under reducing conditions; 52 - 73 kDa, under non-reducing conditions. |
Recombinant Human Serpin A6 Protein (rp144638) - SDS-PAGE
3 μg/lane of Recombinant Human Serpin A6 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 52 - 73 kDa.
| 物理形态 | 冻干(Lyophilized) |
|---|---|
| 储存缓冲液 | Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH7.4. |
| 浓度 | 见COA |
| 复溶 | Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml. |
| 储存温度 | -20°C储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -20~-80℃ 下可保存 1 年以上。收货后建议分装。避免冷冻/解冻循环。 |
| 分子类型 | 蛋白质 |
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 ZJ25F0116974 |
分析证书 | 25-01-16 | rp144638 |
| ZJ25F0116975 |
分析证书 | 25-01-16 | rp144638 |
| ZJ25F0116976 |
分析证书 | 25-01-16 | rp144638 |
| 1. Smith, C L CL, Power, S G SG and Hammond, G L GL.. (1992) A Leu----His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol.. The Journal of steroid biochemistry and molecular biology, [PMID:1504007] |
| 2. Hammond, G L GL and 8 more authors.. (1987) Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:3299377] |
| 3. Kato, E A EA, Hsu, B R BR and Kuhn, R W RW.. (1988) Comparative structural analyses of corticosteroid binding globulin.. Journal of steroid biochemistry, [PMID:3347061] |
| 4. Bardin, C W CW and 7 more authors.. (1988) Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors.. Journal of steroid biochemistry, [PMID:3386241] |
| 5. Van Baelen, H H, Power, S G SG and Hammond, G L GL.. (1993) Decreased cortisol-binding affinity of transcortin Leuven is associated with an amino acid substitution at residue-93.. Steroids, [PMID:8212073] |
| 6. Emptoz-Bonneton, A A and 6 more authors.. (2000) Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity.. The Journal of clinical endocrinology and metabolism, [PMID:10634411] |
| 7. Bunkenborg, Jakob J, Pilch, Bartosz J BJ, Podtelejnikov, Alexandre V AV and Wiśniewski, Jacek R JR.. (2004) Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.. Proteomics, [PMID:14760718] |
| 8. Liu, Tao T and 6 more authors.. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.. Journal of proteome research, [PMID:16335952] |
| 9. Buss, C C and 6 more authors.. (2007) Haploinsufficiency of the SERPINA6 gene is associated with severe muscle fatigue: A de novo mutation in corticosteroid-binding globulin deficiency.. Journal of neural transmission (Vienna, Austria : 1996), [PMID:17245537] |
| 10. Zhou, Aiwu A and 5 more authors.. (2008) The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release.. Journal of molecular biology, (27): [PMID:18513745] |
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