Recombinant Human CD38 Protein

无动物源

无载体

生物活性

ActiBioPure™

无叠氮钠

≥95%(SDS-PAGE)

功能和特点

表达系统: HEK293
Accession #: P28907
蛋白标签: C-His
生物活性: Immobilized Human CD38 Protein at 1μg/mL (100 μL/well) can bind CD38 Rabbit pAb with a linear range of 0.244-3.2 ng/mL.
内毒素水平: <0.1 EU/μg

有货

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货号 (SKU)	包装规格	是否现货
rp143978-10μg	10μg	现货
rp143978-50μg	50μg	现货
rp143978-100μg	100μg	现货
rp143978-1mg	1mg	期货

查看相关系列

点击查看蛋白信息: CD38

Accession#:P28907 (14) CD38 (21) Gene ID:952 (14)

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基本描述

产品名称	Recombinant Human CD38 Protein
别名	重组人CD38蛋白 \| 重组人 CD38 蛋白
英文别名	2'-phospho-ADP-ribosyl cyclase \| 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20) \| 2'-phospho-cyclic-ADP-ribose transferase \| ADPRC 1 \| ADPRC1 \| ADP-ribosyl cyclase 1 \| ADP-ribosyl Cyclase \| ADP-ribosyl cyclase/cycli
规格或纯度	ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, ≥95%(SDS-PAGE)
产品介绍	Purity >95% SDS-PAGE. Function Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
生物活性	Immobilized Human CD38 Protein at 1μg/mL (100 μL/well) can bind CD38 Rabbit pAb with a linear range of 0.244-3.2 ng/mL.
内毒素水平	<0.1 EU/μg
表达系统	HEK293
种属	人(Human)
氨基酸	43-300 aa
序列	VPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEIHHHHHH
纯度	＞95%(SDS-PAGE)
蛋白标签	C-His
无载体	Yes
无动物源	Yes
Accession #	P28907
来源	重组表达
预测分子量	47 kDa
SDS-PAGE	43.0 kDa, under reducing conditions; 43.0 kDa, under non-reducing conditions.

图片

Protein Bioactivity: Recombinant Human CD38 Protein (rp143978)

Recombinant Human CD38 Protein (rp143978) - Protein Bioactivity
Immobilized Human CD38 Protein (rp143978) at 1μg/mL can bind CD38 Antibody with a linear range of 0.244 - 3.2 ng/mL.

SDS-PAGE: Recombinant Human CD38 Protein (rp143978)

Recombinant Human CD38 Protein (rp143978) - SDS-PAGE
3 μg/lane of Recombinant Human CD38 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 43.0 kDa.

产品规格参数

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from 1×PBS, PH7.4, containing 5% trehalose, 5% mannitol
复溶	Reconstitute in sterile H2O to a concentration of 0.1-0.5 mg/ml.
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -20 ~-80℃ 下可存放 1 年以上
分子类型	蛋白质

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到3个结果

批号(Lot Number)	证书类型	日期	货号
ZJ24F0102338	分析证书	24-01-30	rp143978
ZJ24F0102337	分析证书	24-01-30	rp143978
ZJ24F0102335	分析证书	24-01-30	rp143978

参考文献

1. de Weers M, Tai YT, van der Veer MS, Bakker JM, Vink T, Jacobs DC, Oomen LA, Peipp M, Valerius T, Slootstra JW et al.. (2011) Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors.. J Immunol, 186 (3): (1840-8). [PMID:21187443]
2. Jackson DG, Bell JI. (1990) Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation.. J Immunol, 144 (7): (2811-5). [PMID:2319135]
3. Isabelle Kuhn,Esther Kellenberger,Fatouma Said-Hassane,Pascal Villa,Didier Rognan,Annelise Lobstein,Jacques Haiech,Marcel Hibert,Francis Schuber,Hélène Muller-Steffner. (2010-10-19) Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme.. Bioorganic & medicinal chemistry, 18 ((22)): (7900-7910). [PMID:20951593]
4. Swarbrick JM, Graeff R, Zhang H, Thomas MP, Hao Q, Potter BV.. (2014) Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38.. J Med Chem, 57 (20): (8517-8529). [PMID:25226087] [10.1021/jm501037u]
5. Jacques SA, Kuhn I, Koniev O, Schuber F, Lund FE, Wagner A, Muller-Steffner H, Kellenberger E.. (2015) Discovery of Potent Inhibitors of Schistosoma mansoni NAD⁺ Catabolizing Enzyme.. J Med Chem, 58 (8): (3582-3592). [PMID:25803425] [10.1021/acs.jmedchem.5b00203]
6. Becherer JD, Boros EE, Carpenter TY, Cowan DJ, Deaton DN, Haffner CD, Jeune MR, Kaldor IW, Poole JC, Preugschat F, Rheault TR, Schulte CA, Shearer BG, Shearer TW, Shewchuk LM, Smalley TL, Stewart EL, Stuart JD, Ulrich JC.. (2015) Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38.. J Med Chem, 58 (17): (7021-7056). [PMID:26267483] [10.1021/acs.jmedchem.5b00992]
7. Deaton DN, Haffner CD, Henke BR, Jeune MR, Shearer BG, Stewart EL, Stuart JD, Ulrich JC.. (2018) 2,4-Diamino-8-quinazoline carboxamides as novel, potent inhibitors of the NAD hydrolyzing enzyme CD38: Exploration of the 2-position structure-activity relationships.. Bioorg Med Chem, 26 (8): (2107-2150). [PMID:29576271] [10.1016/j.bmc.2018.03.021]
8. States, D J DJ, Walseth, T F TF and Lee, H C HC.. (1992) Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38.. Trends in biochemical sciences, [PMID:1471258]
9. Tohgo, A A and 8 more authors.. (1994) Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38.. The Journal of biological chemistry, (18): [PMID:7961800]
10. Takasawa, S S and 7 more authors.. (1993) Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP.. The Journal of biological chemistry, (15): [PMID:8253715]
11. Nata, K K and 9 more authors.. (1997) Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing.. Gene, (28): [PMID:9074508]
12. Yagui, K K and 13 more authors.. (1998) A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro.. Diabetologia, [PMID:9754820]
13. Hillman, R Tyler RT, Green, Richard E RE and Brenner, Steven E SE.. (2004) An unappreciated role for RNA surveillance.. Genome biology, [PMID:14759258]
14. Liu, Qun Q and 5 more authors.. (2005) Crystal structure of human CD38 extracellular domain.. Structure (London, England : 1993), [PMID:16154090]
15. Wollscheid, Bernd B and 7 more authors.. (2009) Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.. Nature biotechnology, [PMID:19349973]

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Recombinant Human CD38 Protein

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基本描述

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产品规格参数

安全和危险性（GHS）

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质检证书（CoA,COO,BSE/TSE 和分析图谱)

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参考文献

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