基本描述

产品名称

重组人血清白蛋白OsrHSA, 诊断剂

别名

rHSA, 白蛋白人, 重组人血白蛋白

英文别名

规格或纯度

≥96%, lyophilized powder

产品介绍

人血清白蛋白（Human Serum Albumin，HSA）作为人血浆中含量最丰富的蛋白，是激素、脂类等物质的转运载体，其主要生理功能是调节血浆pH值和维持血浆渗透压。

OsrHSA（Recombinant Human Serum Albumin from Oryza sativa）是利用水稻胚乳细胞表达平台（OryzHiExp）和纯化平台（OryzPur）研发的重组人血清白蛋白，不含有动物源成分，可杜绝血液源的病毒感染风险。与胎牛血清（FBS）、血浆来源白蛋白（pHSA）和牛血清白蛋白（BSA）相比，OsrHSA具有更高的纯度，更好的批次稳定性，可以用于各类研究，包括生物制药、细胞治疗、基因治疗的细胞培养等，可替换血清，促进细胞生长。同时，OsrHSA也被广泛用于生物医药生产中作为药物载体，疫苗保护剂、细胞冻存保护剂和医疗器械包埋剂等。

说明：

包装量指的是蛋白的总量，每瓶实际包含“蛋白+保护剂”

应用领域

生物制药、人用疫苗、细胞培养、细胞存储、化药分子载体、医疗器械、体外诊断等。

OsrHSA和天然人白pHSA理化性质比较

理化性质	pHSA	OsrHSA
氨基酸序列	一致
N-端氨基酸	DAHKSEV	DAHKSEV
C-端氨基酸	KLVAASQAALGL	KLVAASQAALGL
糖苷修饰	无
分子量 (MALDl)	66.554 (kDa)	66.550 ( a)
等电点 (pl)	4.8	4.8
药物结合活性	相近
热稳定性	熔点 65℃	熔点 65℃
酯酶活性	相同
晶体结构	相同

OsrHSA系列产品参数和选择指南

项目	R639101
	单体+二聚体(非还原型SDS-PAGE法)≥96.0%
	二聚体+多聚体(非还原型SDS-PAGE法) : > 2.0%
纯度	单体+二聚体(SEC-HPLC法) >98.0% .
	多聚体(SEC-HPLC法) <1.0%
	降解片段(SEC-HPLC法) S1.0%
	二聚体+多聚体(SEC-HPLC法) > 2.0%
性状	淡黄色至白色或灰白色粉末或晶型粉末
鉴别	应为阳性
水分	<5.0%
紫外光谱	279+2nm
吸光度	<0.15
辛酸钠含量	≤0. 180mmol/g蛋白质
微生物限度	菌落总数<100cfug；霉菌及酵母菌总数S10cfu/g
	砷S1.5g/kg
重金属	镉S0.2gkg
	汞<0.3g/kg
	铅s0.5g/kg

使用限制：

以上产品仅适于科研、实验室和生产使用，不能直接使用于人体。

As the most abundant protein in human plasma, human serum albumin (HSA) is the transporter of hormones, lipids and other substances. Its main physiological function is to regulate plasma pH and maintain plasma osmotic pressure.

Osrhsa (recombinant human serum albumin from Oryza sativa) is a recombinant human serum albumin developed by using rice endosperm cell expression platform (oryzhiexp) and purification platform (oryzpur). It does not contain animal derived ingredients and can eliminate the risk of blood derived virus infection. Compared with fetal bovine serum (FBS), plasma derived albumin (pHSA) and bovine serum albumin (BSA), osrhsa has higher purity and better batch stability. It can be used in various research fields, including biopharmaceutical, cell therapy and cell culture of gene therapy. It can replace serum and promote cell growth. At the same time, osrhsa is also widely used in biomedical production as drug carrier, vaccine protector, cell cryoprotectant and medical device embedding agent.

Application

Biopharmaceuticals, human vaccines, cell culture, cell storage, chemical drug molecular carriers, medical devices, in vitro diagnosis, etc.

Comparison of physical and chemical properties between OsrHSA and natural human white pHSA

physicochemical properties	pHSA	OsrHSA
amino acid sequence	agreement
N-terminal amino acids	DAHKSEV	DAHKSEV
C-terminal amino acids	KLVAASQAALGL	KLVAASQAALGL
Glycoside modification	nothing
molecular weight (MALDl)	66.554 (kDa)	66.550 ( a)
Isoelectric point (pl)	4.8	4.8
Drug binding activity	close
thermal stability	mp 65℃	mp 65℃
esterase activity	identical
crystal structure	identical

Restrictions on use:

The above products are only suitable for scientific research, laboratory and production use, and cannot be directly used in human body.

内毒素水平

<0.125 EU/mg

表达系统

种属

人(Human)

氨基酸

25-609 aa

蛋白标签

No tag

Accession #

P02768

作用机制

诊断剂

关联靶点（人）

Homo sapiens (32628 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Rattus norvegicus (775804 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

产品规格参数

浓度	lyophilized powder
储存温度	2-8°C储存
运输条件	冰袋运输
CAS编号和信息	70024-90-7
分子类型	小分子

安全和危险性（GHS）

WGK Germany	3

SDS英文版

质量标准

Total protein content	90-100(%)
Appearance(R639101)	white to greyish-white to light yellow powder or crystalline powder
Bacterial endotoxins	0-0.01（EU/mg）
Purity(Monomer+Dimer)(SDS-PAGE)	96-100（%）

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到2个结果

批号(Lot Number)	证书类型	日期	货号
C2421706	分析证书	24-03-28	R639101
C2421707	分析证书	24-03-28	R639101

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?

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3. Mingguo Peng, Yicui Wang, Chunge Wu, Xuewen Cai, Yao Wu, Erdeng Du, Lu Zheng, Jiajun Fu. (2023) Investigating sulfonamides - Human serum albumin interactions: A comprehensive approach using multi-spectroscopy, DFT calculations, and molecular docking. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 683 (149108). [PMID:37862782] [10.1016/j.bbrc.2023.10.040]
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参考文献

1. Xiong Sheng, Shuai Kang, Bangxing Li, Fengjuan Xue, Wenqiang Lu. (2023) MXene induced two-electron oxygen reduction of Pd for H2O2 generation. ELECTROCHIMICA ACTA, 472 (143420). [10.1016/j.electacta.2023.143420]
2. Gong Xue, Wu Jiangling, Zhang Jiajia, Jiang Zhongwei, Wang Yi, Zhang Pu. (2023) A Robust N-Terminal Pro-Brain Natriuretic Peptide Assay for Clinical Diagnosis of Heart Failure in Elderly Patients. Journal of Analysis and Testing, (1-9). [10.1007/s41664-023-00270-2]
3. Mingguo Peng, Yicui Wang, Chunge Wu, Xuewen Cai, Yao Wu, Erdeng Du, Lu Zheng, Jiajun Fu. (2023) Investigating sulfonamides - Human serum albumin interactions: A comprehensive approach using multi-spectroscopy, DFT calculations, and molecular docking. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 683 (149108). [PMID:37862782] [10.1016/j.bbrc.2023.10.040]
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溶液计算器

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计算溶液所需的质量、体积或浓度。

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稀释计算器

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复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

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质量（小瓶）

所需的复溶浓度

货号 (SKU)	包装规格	是否现货	价格	数量
R639101-1g	1g	期货
R639101-10g	10g	现货

重组人血清白蛋白OsrHSA, 诊断剂

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参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器