首页
400-620-6333
计算溶液所需的质量、体积或浓度。
桔梗皂苷D
- CAS编号: 58479-68-8
- 分子式: C57H92O28
- 分子量: 1225.32
- PubChem编号: 162859
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P424891-1ml |
1ml |
现货  |
|
切换导航
关闭
搜索
基本描述
| 英文别名 | Platycodin D | 58479-68-8 | PlatycodinD | CWJ06TA2GI | CHEBI:70436 | Platycodin-D | UNII-CWJ06TA2GI | PLATYCODIN D [INCI] | CHEMBL1641859 | SCHEMBL23500390 | SINGLEEX PLATYCODIN D 98 | DTXSID901021773 | HMS3887G11 | HY-N1411 | MFCD09952590 | s9304 | AKOS037514784 | CCG-270661 | AC-34319 | BS- |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Platycodin D |
| 生化机理 | 桔梗皂苷D具有较强的抗癌性，对体外和体内来源的多种肿瘤细胞株均具有细胞毒性作用。可通过上调肝X受体α(LXRα)和ATP-结合盒转运蛋白A1(ABCA1)信号传导通路，发挥对脂多糖(LPS)诱导的急性肺损伤(ALI)具有抗炎和保护功效。也对顺铂诱导(CDDP)的小鼠肾毒性具有保护作用。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
桔梗皂苷D (platycodin D)是从桔梗根(Platycodonis Radix)中提取的一种三萜皂苷。 应用
桔梗皂苷D已用于：
Platycodin D (PD) is a triterpenoid saponin found in the root of Platycodon grandifloras called Platycodonis Radix.
|
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | [(2S,3R,4S,5S)-3-[(2S,3R,4S,5R,6S)-5-[(2S,3R,4S,5R)-4-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-3,5-dihydroxyoxan-2-yl]oxy-3,4-dihydroxy-6-methyloxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl] (4aR,5R,6aR,6aS,6bR,8aR,10R,11S,12aR,14bS)-5,11-dihydroxy-9,9-bis(hydroxymethyl)-2,2,6a,6b,12a-pentamethyl-10-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate |
| INCHI | InChI=1S/C57H92O28/c1-23-40(81-45-39(72)41(28(64)18-76-45)82-49-43(73)56(75,21-61)22-78-49)36(69)38(71)46(79-23)83-42-33(66)27(63)17-77-48(42)85-50(74)57-12-11-51(2,3)13-25(57)24-7-8-30-52(4)14-26(62)44(84-47-37(70)35(68)34(67)29(16-58)80-47)55(19-59,20-60)31(52)9-10-53(30,5)54(24,6)15-32(57)65/h7,23,25-49,58-73,75H,8-22H2,1-6H3/t23-,25-,26-,27-,28+,29+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39+,40-,41-,42+,43-,44-,45-,46-,47-,48-,49-,52+,53+,54+,56+,57+/m0/s1 |
| InChi Key | CYBWUNOAQPMRBA-NDTOZIJESA-N |
| Canonical SMILES | O[C@@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C(CO)(CO)[C@]3([H])CC[C@@]4(C)[C@]5(C)C[C@@H](O)[C@@]6(C(O[C@H]7[C@H](O[C@@H]8O[C@@H](C)[C@H](O[C@H]9[C@H](O)[C@@H](O[C@@H]%10OC[C@@](CO)(O)[C@H]%10O)[C@H](O)CO9)[C@@H](O)[C@H]8O)[C@@H](O)[C@@H](O |
| Isomeric SMILES | C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@H](CO[C@H]2OC(=O)[C@]34CCC(C[C@H]3C5=CC[C@H]6[C@]([C@@]5(C[C@H]4O)C)(CC[C@@H]7[C@@]6(C[C@@H]([C@@H](C7(CO)CO)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)O)C)C)(C)C)O)O)O)O)O[C@H]9[C@@H]([C@H]([C@@H](CO9)O)O[C@H]1[C@@H]([C@](CO1)(CO)O)O)O |
| PubChem CID | 162859 |
| 分子量 | 1225.32 |
化学和物理性质
| 敏感性 | 对光；空气敏感 |
|---|---|
| 分子量 | 1225.300 g/mol |
| XLogP3 | -3.700 |
| 氢键供体数Hydrogen Bond Donor Count | 17 |
| 氢键受体数Hydrogen Bond Acceptor Count | 28 |
| 可旋转键计数Rotatable Bond Count | 15 |
| 精确质量Exact Mass | 1224.58 Da |
| 单同位素质量Monoisotopic Mass | 1224.58 Da |
| 拓扑极表面积Topological Polar Surface Area | 453.000 Ų |
| 重原子数Heavy Atom Count | 85 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 2380.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 31 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
质量标准
| Concentration(Compounding value) | 9.0-11.0(mmol/L) |
|---|---|
| Appearance(Colorless Transparent Liquid) | Pass |
| Record the entire process by video | Conform |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
| 1. Qianru Gao, Weiyi Tian, Huabing Yang, Haiming Hu, Junping Zheng, Xiaowei Yao, Baifei Hu, Hongtao Liu. (2023) Shen-Ling-Bai-Zhu-San alleviates the imbalance of intestinal homeostasis in dextran sodium sulfate-induced colitis mice by regulating gut microbiota and inhibiting the NLRP3 inflammasome activation. JOURNAL OF ETHNOPHARMACOLOGY, (117136). [PMID:37704122] [10.1016/j.jep.2023.117136] |
| 2. Chuan-Chuan Zeng, Cheng Zhang, Jun-Hua Yao, Shang-Hai Lai, Bing-Jie Han, Wei Li, Bing Tang, Dan Wan, Yun-Jun Liu. (2016) Platycodin D induced apoptosis and autophagy in PC-12 cells through mitochondrial dysfunction pathway. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 168 (199). [PMID:27294548] [10.1016/j.saa.2016.06.005] |
参考文献
| 1. Qianru Gao, Weiyi Tian, Huabing Yang, Haiming Hu, Junping Zheng, Xiaowei Yao, Baifei Hu, Hongtao Liu. (2023) Shen-Ling-Bai-Zhu-San alleviates the imbalance of intestinal homeostasis in dextran sodium sulfate-induced colitis mice by regulating gut microbiota and inhibiting the NLRP3 inflammasome activation. JOURNAL OF ETHNOPHARMACOLOGY, (117136). [PMID:37704122] [10.1016/j.jep.2023.117136] |
| 2. Chuan-Chuan Zeng, Cheng Zhang, Jun-Hua Yao, Shang-Hai Lai, Bing-Jie Han, Wei Li, Bing Tang, Dan Wan, Yun-Jun Liu. (2016) Platycodin D induced apoptosis and autophagy in PC-12 cells through mitochondrial dysfunction pathway. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 168 (199). [PMID:27294548] [10.1016/j.saa.2016.06.005] |