计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P132032-5g |
5g |
现货 ![]() |
| |
| P132032-10g |
10g |
期货 ![]() |
| |
| P132032-25g |
25g |
现货 ![]() |
| |
| P132032-100g |
100g |
现货 ![]() |
| |
| P132032-500g |
500g |
现货 ![]() |
|
| 别名 | 苯丁酸 | ψ-苯基丁酸 | 4-苯基丁酸 | 4-苯基正丁酸 | 苯丁酸 |
|---|---|
| 英文别名 | 4-Phenyl-n-butyrate | CCG-39733 | FT-0673736 | NCGC00018113-04 | NSC295 | NSC-295 | s3592 | gamma-Phenylbutanoic acid | SpecPlus_000814 | CHEBI:41500 | OBKXEAXTFZPCHS-UHFFFAOYSA- | 2-methyl-1-phenyl-propan-2-amine | g-Phenylbutyrate | g-phenyl-Butyrate | |
| 规格或纯度 | Moligand™, ≥99% |
| 英文名称 | 4-Phenylbutyric Acid |
| 运输条件 | 常规运输 |
| 产品介绍 |
4-Phenylbutyric acid (Benzenebutyric acid) 是一种组蛋白去乙酰化酶 (HDAC) 抑制剂,也是一种内质网应激 (ERS) 抑制剂。4-Phenylbutyric acid 可以用于治疗尿素循环障碍。
4-Phenylbutyric acid (Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and an endoplasmic reticulum stress (ERS) inhibitor. 4-Phenylbutyric acid can be used to treat urea cycle disorders. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 504750811 |
|---|---|
| EC号 | 217-341-8 |
| 分子类型 | 小分子 |
| IUPAC Name | 4-phenylbutanoic acid |
| INCHI | InChI=1S/C10H12O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,12) |
| InChi Key | OBKXEAXTFZPCHS-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC=C(C=C1)CCCC(=O)O |
| Isomeric SMILES | C1=CC=C(C=C1)CCCC(=O)O |
| WGK Germany | 3 |
| 关联CAS | 1821-12-1,1716-12-7 (hydrochloride) |
| PubChem CID | 4775 |
| NSC Number | 295 |
| MeSH Entry Terms | 4-phenylbutyrate;4-phenylbutyric acid;4-phenylbutyric acid, calcium salt;4-phenylbutyric acid, sodium salt;Ammonaps;Buphenyl;sodium 4-phenylbutanoate;sodium 4-phenylbutyrate;sodium phenylbutyrate |
| 分子量 | 164.2 |
| Beilstein号 | 9539 |
| Reaxy-Rn | 638180 |
| 闪点(℉) | 230℉ |
|---|---|
| 闪点(℃) | >110℃ |
| 沸点 | 165℃ |
| 熔点 | 49-53℃ |
| 分子量 | 164.200 g/mol |
| XLogP3 | 2.400 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 2 |
| 可旋转键计数Rotatable Bond Count | 4 |
| 精确质量Exact Mass | 164.084 Da |
| 单同位素质量Monoisotopic Mass | 164.084 Da |
| 拓扑极表面积Topological Polar Surface Area | 37.300 Ų |
| 重原子数Heavy Atom Count | 12 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 137.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染:用水充分清洗。 P321: 特殊处理(请参阅此标签上的...)。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续:寻求医疗帮助。 P332+P317: 如果出现皮肤刺激:请寻求医疗帮助。 P319: 如果你感到不适,请寻求医疗帮助。 |
| WGK Germany | 3 |
| Reaxy-Rn | 638180 |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| Melting point | 49-53(℃) |
|---|---|
| Purity(Neutralization titration) | 98.5-101.5(%) |
| Purity(GC) | 99-100(%) |
| Appearance(P132032) | White to Off-White Solid, Powder, or Crystals |
| Infrared spectrum | Conforms to Structure |
| Solubility in MeOH | almost transparency |
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
| 分析证书 | 24-12-09 | P132032 | |
| 分析证书 | 24-12-09 | P132032 | |
| 分析证书 | 24-12-09 | P132032 | |
| 分析证书 | 24-12-09 | P132032 | |
| 分析证书 | 24-12-09 | P132032 | |
| 分析证书 | 24-06-11 | P132032 | |
| 分析证书 | 23-08-17 | P132032 | |
| 分析证书 | 23-08-17 | P132032 | |
| 分析证书 | 23-08-17 | P132032 | |
| 分析证书 | 23-08-17 | P132032 | |
| 分析证书 | 22-07-25 | P132032 | |
| 分析证书 | 22-07-25 | P132032 | |
| 分析证书 | 22-07-25 | P132032 | |
| 分析证书 | 22-07-25 | P132032 | |
| 分析证书 | 22-07-25 | P132032 | |
| 分析证书 | 22-02-15 | P132032 |
| 1. Shuanghui Wang, Chuhong Chen, Yan Lu. (2023) Epigallocatechin-3-Gallate Reduces Cd-Induced Developmental Toxicity of Bodysize in Caenorhabditis elegans via the PEK-1/eIF-2α/ATF-4 Pathway. MOLECULES, 28 (17): (6344). [PMID:37687170] [10.3390/molecules28176344] |
| 2. Chuhong Chen, Ying Deng, Linyan Liu, Zhenyan Zou, Chenzhong Jin, Zhiyin Chen, Shuanghui Wang. (2023) High-Dose Deltamethrin Induces Developmental Toxicity in Caenorhabditis elegans via IRE-1. MOLECULES, 28 (17): (6303). [PMID:37687132] [10.3390/molecules28176303] |
| 3. Fan Chen, Na Wang, Xinyan Tian, Juan Su, Yan Qin, Rongqiao He, Xiaping He. (2023) The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment. Pharmaceutics, 15 (6): (1568). [PMID:37376018] [10.3390/pharmaceutics15061568] |
| 4. Lin Zhao, Bingling Zhong, Yanyan Zhu, Haoyi Zheng, Xumei Wang, Ying Hou, Jin-Jian Lu, Nana Ai, Xiuli Guo, Wei Ge, Yan-Yan Ma, Xiuping Chen. (2023) Nitrovin (difurazone), an antibacterial growth promoter, induces ROS-mediated paraptosis-like cell death by targeting thioredoxin reductase 1 (TrxR1). BIOCHEMICAL PHARMACOLOGY, 210 (115487). [PMID:36893814] [10.1016/j.bcp.2023.115487] |
| 5. Xiaohui Tan, Dunpeng Cai, Na Chen, Sihao Du, Dongfang Qiao, Xia Yue, Tao Wang, Jia Li, Weibing Xie, Huijun Wang. (2021) Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway. TOXICOLOGY LETTERS, 350 (98). [PMID:34214594] [10.1016/j.toxlet.2021.06.019] |
| 1. Gardian G, Browne SE, Choi DK, Klivenyi P, Gregorio J, Kubilus JK, Ryu H, Langley B, Ratan RR, Ferrante RJ et al.. (2005) Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease.. J Biol Chem, 280 (1): (556-63). [PMID:15494404] |
| 2. Ryu H, Smith K, Camelo SI, Carreras I, Lee J, Iglesias AH, Dangond F, Cormier KA, Cudkowicz ME, Brown Jr RH et al.. (2005) Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice.. J Neurochem, 93 (5): (1087-98). [PMID:15934930] |
| 3. Iannitti T, Palmieri B. (2011) Clinical and experimental applications of sodium phenylbutyrate.. Drugs R D, 11 (3): (227-49). [PMID:21902286] |
| 4. Shuanghui Wang, Chuhong Chen, Yan Lu. (2023) Epigallocatechin-3-Gallate Reduces Cd-Induced Developmental Toxicity of Bodysize in Caenorhabditis elegans via the PEK-1/eIF-2α/ATF-4 Pathway. MOLECULES, 28 (17): (6344). [PMID:37687170] [10.3390/molecules28176344] |
| 5. Chuhong Chen, Ying Deng, Linyan Liu, Zhenyan Zou, Chenzhong Jin, Zhiyin Chen, Shuanghui Wang. (2023) High-Dose Deltamethrin Induces Developmental Toxicity in Caenorhabditis elegans via IRE-1. MOLECULES, 28 (17): (6303). [PMID:37687132] [10.3390/molecules28176303] |
| 6. Fan Chen, Na Wang, Xinyan Tian, Juan Su, Yan Qin, Rongqiao He, Xiaping He. (2023) The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment. Pharmaceutics, 15 (6): (1568). [PMID:37376018] [10.3390/pharmaceutics15061568] |
| 7. Lin Zhao, Bingling Zhong, Yanyan Zhu, Haoyi Zheng, Xumei Wang, Ying Hou, Jin-Jian Lu, Nana Ai, Xiuli Guo, Wei Ge, Yan-Yan Ma, Xiuping Chen. (2023) Nitrovin (difurazone), an antibacterial growth promoter, induces ROS-mediated paraptosis-like cell death by targeting thioredoxin reductase 1 (TrxR1). BIOCHEMICAL PHARMACOLOGY, 210 (115487). [PMID:36893814] [10.1016/j.bcp.2023.115487] |
| 8. Xiaohui Tan, Dunpeng Cai, Na Chen, Sihao Du, Dongfang Qiao, Xia Yue, Tao Wang, Jia Li, Weibing Xie, Huijun Wang. (2021) Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway. TOXICOLOGY LETTERS, 350 (98). [PMID:34214594] [10.1016/j.toxlet.2021.06.019] |