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| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
1，1-二甲基双胍, MATE2;多种药物和毒素挤压
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| N425317-1ml |
1ml |
现货  |
|
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基本描述
| 别名 | 二甲双胍 | N,N-二甲基二胍 |
|---|---|
| 英文别名 | metformin | 657-24-9 | 1,1-Dimethylbiguanide | N,N-dimethylimidodicarbonimidic diamide | Fluamine | Metiguanide | Dimethylbiguanide | Flumamine | Gliguanid | Haurymelin | Metformine | Melbin | Imidodicarbonimidic diamide, N,N-dimethyl- | N,N-Dimethylbiguanide | Islotin | Dimethyldigua |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | N,N-Dimethylimidodicarbonimidic diamide |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用机制 | MATE2;多种药物和毒素挤压 |
| 产品介绍 |
Metformin (1,1-Dimethylbiguanide) 抑制肝脏中的线粒体呼吸链，导致 AMPK 活化，增强胰岛素敏感性。Metformin 可以透过血脑屏障，诱导自噬 (autophagy)。 |
关联靶点（人）
SLC47A2
Tchem
多药和毒素挤出蛋白 2(Multidrug and toxin extrusion protein 2)
(0 活性数据)
SLC47A1
Tchem
多药和毒素挤出蛋白 1(Multidrug and toxin extrusion protein 1)
(0 活性数据)
PDE5A
Tclin
Phosphodiesterase 5A
(5113 活性数据)
DHFR
Tclin
Dihydrofolate reductase
(3072 活性数据)
EGFR
Tclin
Epidermal growth factor receptor erbB1
(33727 活性数据)
F2
Tclin
Thrombin
(11687 活性数据)
CA2
Tclin
Carbonic anhydrase II
(17698 活性数据)
ESR1
Tclin
Estrogen receptor alpha
(17718 活性数据)
HMGCR
Tclin
HMG-CoA reductase
(2475 活性数据)
NR3C1
Tclin
Glucocorticoid receptor
(14987 活性数据)
INSR
Tclin
Insulin receptor
(5558 活性数据)
PGR
Tclin
Progesterone receptor
(8562 活性数据)
ADRB2
Tclin
Beta-2 adrenergic receptor
(11824 活性数据)
CHRM2
Tclin
Muscarinic acetylcholine receptor M2
(10671 活性数据)
ADRB1
Tclin
Beta-1 adrenergic receptor
(6630 活性数据)
HTR1A
Tclin
Serotonin 1a (5-HT1a) receptor
(14969 活性数据)
ADRA2A
Tclin
Alpha-2a adrenergic receptor
(9450 活性数据)
AR
Tclin
Androgen Receptor
(11781 活性数据)
CHRM1
Tclin
Muscarinic acetylcholine receptor M1
(12690 活性数据)
ACE
Tclin
Angiotensin-converting enzyme
(1423 活性数据)
DRD2
Tclin
Dopamine D2 receptor
(23596 活性数据)
GABRA1
Tclin
GABA receptor alpha-1 subunit
(399 活性数据)
MAOA
Tclin
Monoamine oxidase A
(11911 活性数据)
CNR1
Tclin
Cannabinoid CB1 receptor
(20913 活性数据)
DRD1
Tclin
Dopamine D1 receptor
(9720 活性数据)
DRD4
Tchem
Dopamine D4 receptor
(7907 活性数据)
ACHE
Tclin
Acetylcholinesterase
(18204 活性数据)
PTGS1
Tclin
Cyclooxygenase-1
(9233 活性数据)
SLC6A2
Tclin
Norepinephrine transporter
(10102 活性数据)
HRH2
Tclin
Histamine H2 receptor
(5428 活性数据)
ADRA1D
Tclin
Alpha-1d adrenergic receptor
(4171 活性数据)
HTR1B
Tclin
Serotonin 1b (5-HT1b) receptor
(2801 活性数据)
HTR2A
Tclin
Serotonin 2a (5-HT2a) receptor
(14758 活性数据)
HTR2C
Tclin
Serotonin 2c (5-HT2c) receptor
(11471 活性数据)
AVPR2
Tclin
Vasopressin V2 receptor
(2912 活性数据)
ADORA1
Tclin
Adenosine A1 receptor
(17603 活性数据)
AGTR1
Tclin
Type-1 angiotensin II receptor
(5176 活性数据)
CALCR
Tclin
Calcitonin receptor
(2215 活性数据)
SLC6A4
Tclin
Serotonin transporter
(12625 活性数据)
CRHR1
Tclin
Corticotropin releasing factor receptor 1
(2996 活性数据)
ADRA1A
Tclin
Alpha-1a adrenergic receptor
(8359 活性数据)
PTGS2
Tclin
Cyclooxygenase-2
(13999 活性数据)
HRH1
Tclin
Histamine H1 receptor
(7573 活性数据)
ADRA1B
Tclin
Alpha-1b adrenergic receptor
(2912 活性数据)
OPRM1
Tclin
Mu opioid receptor
(19785 活性数据)
DRD3
Tclin
Dopamine D3 receptor
(14368 活性数据)
PPARG
Tclin
Peroxisome proliferator-activated receptor gamma
(15191 活性数据)
AVPR1A
Tclin
Vasopressin V1a receptor
(5412 活性数据)
OPRD1
Tclin
Delta opioid receptor
(15096 活性数据)
OPRK1
Tclin
Kappa opioid receptor
(16155 活性数据)
HTR3A
Tclin
Serotonin 3a (5-HT3a) receptor
(3366 活性数据)
GCGR
Tclin
Glucagon receptor
(2563 活性数据)
关联靶点（其它种属）
Agtr2
Angiotensin II type 2 (AT-2) receptor (803 活性数据)
Mc4r
Melanocortin receptor 4 (1205 活性数据)
Ltc4s
Leukotriene C4 synthase (1 活性数据)
Sigmar1
Sigma opioid receptor (160 活性数据)
Npy1r
Neuropeptide Y receptor type 1 (8 活性数据)
Cckar
Cholecystokinin A receptor (90 活性数据)
Ntsr1
Neurotensin receptor 1 (48 活性数据)
Pde4d
Phosphodiesterase 4D (4 活性数据)
Bdkrb1
Bradykinin B1 receptor (77 活性数据)
DPP4
Dipeptidyl peptidase IV (11 活性数据)
Nos2
Nitric oxide synthase, inducible (3573 活性数据)
Mapk1
MAP kinase ERK2 (650 活性数据)
Hdac6
Histone deacetylase 6 (222 活性数据)
Ptpn1
Protein-tyrosine phosphatase 1B (270 活性数据)
Mmp9
Matrix metalloproteinase 9 (38 活性数据)
Pkm
Pyruvate kinase isozymes M1/M2 (66 活性数据)
Hcar2
Hydroxycarboxylic acid receptor 2 (55 活性数据)
Nakaseomyces glabratus (9108 活性数据)
Cavia porcellus (23802 活性数据)
Caenorhabditis elegans (1055 活性数据)
Mus musculus (284745 活性数据)
Rattus norvegicus (775804 活性数据)
3T3-L1 (3664 活性数据)
H4 (48 活性数据)
L6 (7924 活性数据)
GCN5
Histone acetyltransferase GCN5 (89 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
Brain (1 活性数据)
Plasma (328 活性数据)
Kidney (1278 活性数据)
Muscle (539 活性数据)
Pancreas (361 活性数据)
FTL
Ferritin light chain (43324 活性数据)
Glra2
Glycine receptor (1745 活性数据)
SARS-CoV-2 (38078 活性数据)
Vero C1008 (1716 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| EC号 | 211-517-8 |
|---|---|
| 分子类型 | 小分子 |
| IUPAC Name | 3-(diaminomethylidene)-1,1-dimethylguanidine |
| INCHI | InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8) |
| InChi Key | XZWYZXLIPXDOLR-UHFFFAOYSA-N |
| Canonical SMILES | CN(C)C(=N)N=C(N)N |
| Isomeric SMILES | CN(C)C(=N)N=C(N)N |
| 关联CAS | 657-24-9,1115-70-4 |
| PubChem CID | 4091 |
| MeSH Entry Terms | Dimethylbiguanidine;Dimethylguanylguanidine;Glucophage;HCl, Metformin;Hydrochloride, Metformin;Metformin;Metformin HCl;Metformin Hydrochloride |
| 分子量 | 129.16 |
化学和物理性质
| 分子量 | 129.160 g/mol |
|---|---|
| XLogP3 | -1.300 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 1 |
| 可旋转键计数Rotatable Bond Count | 2 |
| 精确质量Exact Mass | 129.101 Da |
| 单同位素质量Monoisotopic Mass | 129.101 Da |
| 拓扑极表面积Topological Polar Surface Area | 91.500 Ų |
| 重原子数Heavy Atom Count | 9 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 132.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
质量标准
| Concentration | |
|---|---|
| Proton NMR spectrum | Conforms to Structure |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
| 1. Changsheng Zhong, Yilin Xie, Huifang Wang, Wenxian Chen, Zhenbo Yang, Lei Zhang, Qin Deng, Ting Cheng, Mengyang Li, Jin Ju, Yanyan Liu, Haihai Liang. (2023) Berberine inhibits NLRP3 inflammasome activation by regulating mTOR/mtROS axis to alleviate diabetic cardiomyopathy. EUROPEAN JOURNAL OF PHARMACOLOGY, (176253). [PMID:38096968] [10.1016/j.ejphar.2023.176253] |
| 2. Wanbo Zhu, Dongdong Xu, Jiawei Mei, Baoliang Lu, Qiaojie Wang, Chen Zhu, Xianzuo Zhang, Xianlong Zhang. (2023) Metformin reverses impaired osteogenesis due to hyperglycemia-induced neutrophil extracellular traps formation. BONE, (116889). [PMID:37660937] [10.1016/j.bone.2023.116889] |
| 3. Xiang Li, Rongxia Li, Xueyu Wang, Xinying Zhang, Zhiyi Xiao, Haibo Wang, Wenhui Sun, Hao Yang, Peng Yu, Qing Hu, Qinghui Guo, Hua Sun. (2023) Effects and mechanism of action of Chrysanthemum morifolium (Jinsi Huangju) on hyperlipidemia and non-alcoholic fatty liver disease. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 255 (115391). [PMID:37099836] [10.1016/j.ejmech.2023.115391] |
| 4. Panmei Jiang, Yingxiang Ye, Jian Liu, Fangbin Wang. (2023) Metformin promotes bacterial surface aggregation by inhibiting the swimming motility of flagellated Escherichia coli. JOURNAL OF BASIC MICROBIOLOGY, [PMID:37058007] [10.1002/jobm.202200716] |
| 5. Zixian He, Zhiwei Liu, Haihuan Xie, Pengjie Luo, Xiangmei Li. (2023) An Ultrasensitive Lateral Flow Immunoassay Based on Metal-Organic Framework-Decorated Polydopamine for Multiple Sulfonylureas Adulteration in Functional Foods. Foods, 12 (3): (539). [PMID:36766067] [10.3390/foods12030539] |
| 6. Wu Yue, Yang Jingjuan, Xu Chengmei, Li Qiuqi, Ma Yage, Zhao Shenglan, Zhuang Jiachen, Shen Fei, Wang Qianqian, Feng Fengqin, Zhang Xi. (2022) Sea cucumber (Acaudina leucoprocta) peptides extended the lifespan and enhanced antioxidant capacity via DAF-16/DAF-2/SOD-3/OLD-1/PEPT-1 in Caenorhabditis elegans. Frontiers in Nutrition, 9 [PMID:36483922] [10.3389/fnut.2022.1065145] |
| 7. Xueyan Gou, Fenglin Ran, Jinru Yang, Yanrong Ma, Xin’an Wu. (2022) Construction and Evaluation of a Novel Organic Anion Transporter 1/3 CRISPR/Cas9 Double-Knockout Rat Model. Pharmaceutics, 14 (11): (2307). [PMID:36365126] [10.3390/pharmaceutics14112307] |
| 8. Wenjie Zhong, Xinyan Wang, Lanxin Yang, Yue Wang, Qingyue Xiao, Simin Yu, Richard D. Cannon, Yan Bai, Chuangwei Zhang, Duanjing Chen, Ping Ji, Xiang Gao, Jinlin Song. (2022) Nanocarrier-Assisted Delivery of Metformin Boosts Remodeling of Diabetic Periodontal Tissue via Cellular Exocytosis-Mediated Regulation of Endoplasmic Reticulum Homeostasis. ACS Nano, 16 (11): (19096–19113). [PMID:36259964] [10.1021/acsnano.2c08146] |
| 9. Hengte Xing, Chuancai Liang, Chenyu Wang, Xiongfeng Xu, Yong Hu, Bo Qiu. (2022) Metformin mitigates cholesterol accumulation via the AMPK/SIRT1 pathway to protect osteoarthritis chondrocytes. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 632 (113). [PMID:36206595] [10.1016/j.bbrc.2022.09.074] |
| 10. Kezhong Tang, Qing Chen, Yanmo Liu, Lantian Wang, Wenjie Lu. (2022) Combination of Metformin and Sorafenib Induces Ferroptosis of Hepatocellular Carcinoma Through p62-Keap1-Nrf2 Pathway. Journal of Cancer, 13 (11): ( 3234–3243). [PMID:36118519] [10.7150/jca.76618] |
| 11. Yuxi Guo, Xuefeng Chen, Pin Gong, Jing Guo, Dan Deng, Guanglian He, Chenglong Ji, Ruotong Wang, Hui Long, Jiating Wang, Wenbo Yao, Wenjuan Yang, Fuxin Chen. (2022) Effect of shiitake mushrooms polysaccharide and chitosan coating on softening and browning of shiitake mushrooms (Lentinus edodes) during postharvest storage. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 218 (816). [PMID:35907449] [10.1016/j.ijbiomac.2022.07.193] |
| 12. Sa Yang, Shijie Cao, Congyu Li, Jichao Zhang, Chang Liu, Feng Qiu, Ning Kang. (2022) Berberrubine, a Main Metabolite of Berberine, Alleviates Non-Alcoholic Fatty Liver Disease via Modulating Glucose and Lipid Metabolism and Restoring Gut Microbiota. Frontiers in Pharmacology, 13 (913378). [PMID:35873595] [10.3389/fphar.2022.913378] |
| 13. Xiangjuan Wei, Daqian Yang, Boya Zhang, Xingpei Fan, Haining Du, Ruijiao Zhu, Xiaotong Sun, Meimei Zhao, Ning Gu. (2022) Di-(2-ethylhexyl) phthalate increases plasma glucose and induces lipid metabolic disorders via FoxO1 in adult mice. SCIENCE OF THE TOTAL ENVIRONMENT, 842 (156815). [PMID:35750186] [10.1016/j.scitotenv.2022.156815] |
| 14. Yuxi Guo, Xuefeng Chen, Pin Gong, Mengrao Wang, Wenbo Yao, Wenjuan Yang, Fuxin Chen. (2022) Effects of simulated saliva-gastrointestinal digestion on the physicochemical properties and bioactivities of Siraitia grosvenorii polysaccharides. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 57 (7): (4495-4506). [10.1111/ijfs.15783] |
| 15. Ying Zhang, Yanna Pan, Jiaqi Li, Zeng Zhang, Yanming He, Hongjie Yang, Ping Zhou. (2022) Inhibition on α-Glucosidase Activity and Non-Enzymatic Glycation by an Anti-Oxidative Proteoglycan from Ganoderma lucidum. MOLECULES, 27 (5): (1457). [PMID:35268560] [10.3390/molecules27051457] |
| 16. Hu Nan, Zhang Qi, Wang Hui, Yang Xuping, Jiang Yan, Chen Rong, Wang Liying. (2022) Comparative Evaluation of the Effect of Metformin and Insulin on Gut Microbiota and Metabolome Profiles of Type 2 Diabetic Rats Induced by the Combination of Streptozotocin and High-Fat Diet. Frontiers in Pharmacology, 12 [PMID:35046817] [10.3389/fphar.2021.794103] |
| 17. Li-na Ji, Shan Wu, Dan-qing Fu, Si-jia Fang, Guan-qun Xie, Yong-sheng Fan, Jie Bao. (2022) Jieduquyuziyin Prescription alleviates hepatic gluconeogenesis via PI3K/Akt/PGC-1α pathway in glucocorticoid-induced MRL/lpr mice. JOURNAL OF ETHNOPHARMACOLOGY, 284 (114815). [PMID:34763039] [10.1016/j.jep.2021.114815] |
| 18. Hong Wen, Yang Fei, Ruisi Cai, Xuemei Yao, Yanan Li, Xuan Wang, Chencheng Xue, Yan Hu, Menghuan Li, Zhong Luo. (2021) Tumor-activatable biomineralized nanotherapeutics for integrative glucose starvation and sensitized metformin therapy. BIOMATERIALS, 278 (121165). [PMID:34649197] [10.1016/j.biomaterials.2021.121165] |
| 19. Dandan Zheng, Wei Chen, Huitong Ruan, Zhengwei Cai, Xiuyuan Chen, Tongtong Chen, Yuhui Zhang, Wenguo Cui, Hao Chen, Hongxing Shen. (2022) Metformin-hydrogel with glucose responsiveness for chronic inflammatory suppression. CHEMICAL ENGINEERING JOURNAL, 428 (131064). [10.1016/j.cej.2021.131064] |
| 20. Xian-Mei Song, Bing-Jie Li, Yan-Yan Zhang, Wen-Jing Ge, She-Feng Zhang, Wei-Feng Cui, Geng-Sheng Li, Rui-Feng Liang. (2021) Rutaecarpine enhances the anti-diabetic activity and hepatic distribution of metformin via up-regulation of Oct1 in diabetic rats. XENOBIOTICA, 51 (7): (818-830). [PMID:33952086] [10.1080/00498254.2021.1926573] |
| 21. Yuan Guan, Hefei Sun, Huiying Chen, Peijun Li, Yang Shan, Xia Li. (2021) Physicochemical characterization and the hypoglycemia effects of polysaccharide isolated from Passiflora edulis Sims peel. Food & Function, 12 (9): (4221-4230). [PMID:33876796] [10.1039/D0FO02965C] |
| 22. Mei Wang, Shan-Quan Chang, Yu-Shan Tian, Ge-Qiang Zhang, Jin Qi. (2020) Zengye Decoction Ameliorates Insulin Resistance by Promoting Glucose Uptake. REJUVENATION RESEARCH, 23 (5): (367-376). [PMID:31941423] [10.1089/rej.2019.2228] |
| 23. Na Deng, Ruixue Guo, Bisheng Zheng, Tong Li, Rui Hai Liu. (2020) IRS-1/PI3K/Akt pathway and miRNAs are involved in whole grain highland barley (Hordeum vulgare L.) ameliorating hyperglycemia of db/db mice. Food & Function, 11 (11): (9535-9546). [PMID:33104141] [10.1039/D0FO01990A] |
| 24. Huang Chunyu, Zhu Chang, Chen Jie, Huang Kaibin, Li Fang, Ding Shunkai, Xia Ligang, Jiang Wei, Li Yang. (2020) Nano-Platelets as an Oxygen Regulator for Augmenting Starvation Therapy Against Hypoxic Tumor. Frontiers in Bioengineering and Biotechnology, 8 (1060). [PMID:33015023] [10.3389/fbioe.2020.571993] |
| 25. Junping Zheng, Yanlei Guo, Baifei Hu, Lin Zhu, Yong Yang, Shengrong Li, Na Li, Hongtao Liu. (2020) Serum metabolomic profiles reveal the impact of BuZangTongLuo formula on metabolic pathways in diabetic mice with hindlimb ischemia. JOURNAL OF ETHNOPHARMACOLOGY, 258 (112928). [PMID:32371144] [10.1016/j.jep.2020.112928] |
| 26. Junping Zheng, Man Chen, Cheng Ye, Xiongjie Sun, Nan Jiang, Xiaojuan Zou, Huabing Yang, Hongtao Liu. (2020) BuZangTongLuo decoction improved hindlimb ischemia by activating angiogenesis and regulating gut microbiota in diabetic mice. JOURNAL OF ETHNOPHARMACOLOGY, 248 (112330). [PMID:31654796] [10.1016/j.jep.2019.112330] |
| 27. Yang Zhang, Dongning Chai, Mengyue Gao, Bin Xu, Guohua Jiang. (2019) Thermal ablation of separable microneedles for transdermal delivery of metformin on diabetic rats. International Journal of Polymeric Materials and Polymeric Biomaterials, [10.1080/00914037.2018.1517347] |
| 28. Yongsheng Chen, Erpei Wang, Zihao Wei, Yanfang Zheng, Rian Yan, Xiang Ma. (2019) Phytochemical analysis, cellular antioxidant and α-glucosidase inhibitory activities of various herb plant organs. INDUSTRIAL CROPS AND PRODUCTS, 141 (111771). [10.1016/j.indcrop.2019.111771] |
| 29. Jing Chen, Guo Zheng, Hu Guo, Zhong-nan Shi, Jiao Jiang, Xiao-yu Wang, Xiao Yang, Xian-yu Liu. (2018) The effect of metformin treatment on endoplasmic reticulum (ER) stress induced by status epilepticus (SE) via the PERK-eIF2α-CHOP pathway. Bosnian Journal of Basic Medical Sciences, 18 (1): ( 49–54). [PMID:28686850] [10.17305/bjbms.2017.2044] |
| 30. Peng Mei, Huang Yanjun, Tao Ting, Peng Cai-Yun, Su Qiongli, Xu Wanjun, Darko Kwame Oteng, Tao Xiaojun, Yang Xiaoping. (2016) Metformin and gefitinib cooperate to inhibit bladder cancer growth via both AMPK and EGFR pathways joining at Akt and Erk. Scientific Reports, 6 (1): (1-10). [PMID:27334428] [10.1038/srep28611] |
| 31. Mei Peng, Qiongli Su, Qing Zeng, Le Li, Zhihong Liu, Lei Xue, Yan Cheng, Yanjun Huang, Ting Tao, Hongwei Lv, Xiaohui Li, Xiaojun Tao, Peng Guo, Alex F. Chen, Xiaoping Yang. (2016) High efficacy of intravesical treatment of metformin on bladder cancer in preclinical model. Oncotarget, 7 (8): ( 9102–9117). [PMID:26802022] [10.18632/oncotarget.6933] |
| 32. Qiongli Su,Ting Tao,Lei Tang,Jun Deng,Kwame Oteng Darko,Sichun Zhou,Mei Peng,Shanping He,Qing Zeng,Alex F Chen,Xiaoping Yang. (2018-03-08) Down-regulation of PKM2 enhances anticancer efficiency of THP on bladder cancer.. Journal of cellular and molecular medicine, 22 ((5)): (2774-2790). [PMID:29512924] |
| 33. Li Y, Zhao P, Chen Y, Fu Y, Shi K, Liu L, Liu H, Xiong M, Liu QH, Yang G, Xiao Y.. (2017) Depsidone and xanthones from Garcinia xanthochymus with hypoglycemic activity and the mechanism of promoting glucose uptake in L6 myotubes.. Bioorg Med Chem, 25 (24): (6605-6613). [PMID:29128163] [10.1016/j.bmc.2017.10.043] |
参考文献
| 1. Changsheng Zhong, Yilin Xie, Huifang Wang, Wenxian Chen, Zhenbo Yang, Lei Zhang, Qin Deng, Ting Cheng, Mengyang Li, Jin Ju, Yanyan Liu, Haihai Liang. (2023) Berberine inhibits NLRP3 inflammasome activation by regulating mTOR/mtROS axis to alleviate diabetic cardiomyopathy. EUROPEAN JOURNAL OF PHARMACOLOGY, (176253). [PMID:38096968] [10.1016/j.ejphar.2023.176253] |
| 2. Wanbo Zhu, Dongdong Xu, Jiawei Mei, Baoliang Lu, Qiaojie Wang, Chen Zhu, Xianzuo Zhang, Xianlong Zhang. (2023) Metformin reverses impaired osteogenesis due to hyperglycemia-induced neutrophil extracellular traps formation. BONE, (116889). [PMID:37660937] [10.1016/j.bone.2023.116889] |
| 3. Xiang Li, Rongxia Li, Xueyu Wang, Xinying Zhang, Zhiyi Xiao, Haibo Wang, Wenhui Sun, Hao Yang, Peng Yu, Qing Hu, Qinghui Guo, Hua Sun. (2023) Effects and mechanism of action of Chrysanthemum morifolium (Jinsi Huangju) on hyperlipidemia and non-alcoholic fatty liver disease. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 255 (115391). [PMID:37099836] [10.1016/j.ejmech.2023.115391] |
| 4. Panmei Jiang, Yingxiang Ye, Jian Liu, Fangbin Wang. (2023) Metformin promotes bacterial surface aggregation by inhibiting the swimming motility of flagellated Escherichia coli. JOURNAL OF BASIC MICROBIOLOGY, [PMID:37058007] [10.1002/jobm.202200716] |
| 5. Zixian He, Zhiwei Liu, Haihuan Xie, Pengjie Luo, Xiangmei Li. (2023) An Ultrasensitive Lateral Flow Immunoassay Based on Metal-Organic Framework-Decorated Polydopamine for Multiple Sulfonylureas Adulteration in Functional Foods. Foods, 12 (3): (539). [PMID:36766067] [10.3390/foods12030539] |
| 6. Wu Yue, Yang Jingjuan, Xu Chengmei, Li Qiuqi, Ma Yage, Zhao Shenglan, Zhuang Jiachen, Shen Fei, Wang Qianqian, Feng Fengqin, Zhang Xi. (2022) Sea cucumber (Acaudina leucoprocta) peptides extended the lifespan and enhanced antioxidant capacity via DAF-16/DAF-2/SOD-3/OLD-1/PEPT-1 in Caenorhabditis elegans. Frontiers in Nutrition, 9 [PMID:36483922] [10.3389/fnut.2022.1065145] |
| 7. Xueyan Gou, Fenglin Ran, Jinru Yang, Yanrong Ma, Xin’an Wu. (2022) Construction and Evaluation of a Novel Organic Anion Transporter 1/3 CRISPR/Cas9 Double-Knockout Rat Model. Pharmaceutics, 14 (11): (2307). [PMID:36365126] [10.3390/pharmaceutics14112307] |
| 8. Wenjie Zhong, Xinyan Wang, Lanxin Yang, Yue Wang, Qingyue Xiao, Simin Yu, Richard D. Cannon, Yan Bai, Chuangwei Zhang, Duanjing Chen, Ping Ji, Xiang Gao, Jinlin Song. (2022) Nanocarrier-Assisted Delivery of Metformin Boosts Remodeling of Diabetic Periodontal Tissue via Cellular Exocytosis-Mediated Regulation of Endoplasmic Reticulum Homeostasis. ACS Nano, 16 (11): (19096–19113). [PMID:36259964] [10.1021/acsnano.2c08146] |
| 9. Hengte Xing, Chuancai Liang, Chenyu Wang, Xiongfeng Xu, Yong Hu, Bo Qiu. (2022) Metformin mitigates cholesterol accumulation via the AMPK/SIRT1 pathway to protect osteoarthritis chondrocytes. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 632 (113). [PMID:36206595] [10.1016/j.bbrc.2022.09.074] |
| 10. Kezhong Tang, Qing Chen, Yanmo Liu, Lantian Wang, Wenjie Lu. (2022) Combination of Metformin and Sorafenib Induces Ferroptosis of Hepatocellular Carcinoma Through p62-Keap1-Nrf2 Pathway. Journal of Cancer, 13 (11): ( 3234–3243). [PMID:36118519] [10.7150/jca.76618] |
| 11. Yuxi Guo, Xuefeng Chen, Pin Gong, Jing Guo, Dan Deng, Guanglian He, Chenglong Ji, Ruotong Wang, Hui Long, Jiating Wang, Wenbo Yao, Wenjuan Yang, Fuxin Chen. (2022) Effect of shiitake mushrooms polysaccharide and chitosan coating on softening and browning of shiitake mushrooms (Lentinus edodes) during postharvest storage. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 218 (816). [PMID:35907449] [10.1016/j.ijbiomac.2022.07.193] |
| 12. Sa Yang, Shijie Cao, Congyu Li, Jichao Zhang, Chang Liu, Feng Qiu, Ning Kang. (2022) Berberrubine, a Main Metabolite of Berberine, Alleviates Non-Alcoholic Fatty Liver Disease via Modulating Glucose and Lipid Metabolism and Restoring Gut Microbiota. Frontiers in Pharmacology, 13 (913378). [PMID:35873595] [10.3389/fphar.2022.913378] |
| 13. Xiangjuan Wei, Daqian Yang, Boya Zhang, Xingpei Fan, Haining Du, Ruijiao Zhu, Xiaotong Sun, Meimei Zhao, Ning Gu. (2022) Di-(2-ethylhexyl) phthalate increases plasma glucose and induces lipid metabolic disorders via FoxO1 in adult mice. SCIENCE OF THE TOTAL ENVIRONMENT, 842 (156815). [PMID:35750186] [10.1016/j.scitotenv.2022.156815] |
| 14. Yuxi Guo, Xuefeng Chen, Pin Gong, Mengrao Wang, Wenbo Yao, Wenjuan Yang, Fuxin Chen. (2022) Effects of simulated saliva-gastrointestinal digestion on the physicochemical properties and bioactivities of Siraitia grosvenorii polysaccharides. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 57 (7): (4495-4506). [10.1111/ijfs.15783] |
| 15. Ying Zhang, Yanna Pan, Jiaqi Li, Zeng Zhang, Yanming He, Hongjie Yang, Ping Zhou. (2022) Inhibition on α-Glucosidase Activity and Non-Enzymatic Glycation by an Anti-Oxidative Proteoglycan from Ganoderma lucidum. MOLECULES, 27 (5): (1457). [PMID:35268560] [10.3390/molecules27051457] |
| 16. Hu Nan, Zhang Qi, Wang Hui, Yang Xuping, Jiang Yan, Chen Rong, Wang Liying. (2022) Comparative Evaluation of the Effect of Metformin and Insulin on Gut Microbiota and Metabolome Profiles of Type 2 Diabetic Rats Induced by the Combination of Streptozotocin and High-Fat Diet. Frontiers in Pharmacology, 12 [PMID:35046817] [10.3389/fphar.2021.794103] |
| 17. Li-na Ji, Shan Wu, Dan-qing Fu, Si-jia Fang, Guan-qun Xie, Yong-sheng Fan, Jie Bao. (2022) Jieduquyuziyin Prescription alleviates hepatic gluconeogenesis via PI3K/Akt/PGC-1α pathway in glucocorticoid-induced MRL/lpr mice. JOURNAL OF ETHNOPHARMACOLOGY, 284 (114815). [PMID:34763039] [10.1016/j.jep.2021.114815] |
| 18. Hong Wen, Yang Fei, Ruisi Cai, Xuemei Yao, Yanan Li, Xuan Wang, Chencheng Xue, Yan Hu, Menghuan Li, Zhong Luo. (2021) Tumor-activatable biomineralized nanotherapeutics for integrative glucose starvation and sensitized metformin therapy. BIOMATERIALS, 278 (121165). [PMID:34649197] [10.1016/j.biomaterials.2021.121165] |
| 19. Dandan Zheng, Wei Chen, Huitong Ruan, Zhengwei Cai, Xiuyuan Chen, Tongtong Chen, Yuhui Zhang, Wenguo Cui, Hao Chen, Hongxing Shen. (2022) Metformin-hydrogel with glucose responsiveness for chronic inflammatory suppression. CHEMICAL ENGINEERING JOURNAL, 428 (131064). [10.1016/j.cej.2021.131064] |
| 20. Xian-Mei Song, Bing-Jie Li, Yan-Yan Zhang, Wen-Jing Ge, She-Feng Zhang, Wei-Feng Cui, Geng-Sheng Li, Rui-Feng Liang. (2021) Rutaecarpine enhances the anti-diabetic activity and hepatic distribution of metformin via up-regulation of Oct1 in diabetic rats. XENOBIOTICA, 51 (7): (818-830). [PMID:33952086] [10.1080/00498254.2021.1926573] |
| 21. Yuan Guan, Hefei Sun, Huiying Chen, Peijun Li, Yang Shan, Xia Li. (2021) Physicochemical characterization and the hypoglycemia effects of polysaccharide isolated from Passiflora edulis Sims peel. Food & Function, 12 (9): (4221-4230). [PMID:33876796] [10.1039/D0FO02965C] |
| 22. Mei Wang, Shan-Quan Chang, Yu-Shan Tian, Ge-Qiang Zhang, Jin Qi. (2020) Zengye Decoction Ameliorates Insulin Resistance by Promoting Glucose Uptake. REJUVENATION RESEARCH, 23 (5): (367-376). [PMID:31941423] [10.1089/rej.2019.2228] |
| 23. Na Deng, Ruixue Guo, Bisheng Zheng, Tong Li, Rui Hai Liu. (2020) IRS-1/PI3K/Akt pathway and miRNAs are involved in whole grain highland barley (Hordeum vulgare L.) ameliorating hyperglycemia of db/db mice. Food & Function, 11 (11): (9535-9546). [PMID:33104141] [10.1039/D0FO01990A] |
| 24. Huang Chunyu, Zhu Chang, Chen Jie, Huang Kaibin, Li Fang, Ding Shunkai, Xia Ligang, Jiang Wei, Li Yang. (2020) Nano-Platelets as an Oxygen Regulator for Augmenting Starvation Therapy Against Hypoxic Tumor. Frontiers in Bioengineering and Biotechnology, 8 (1060). [PMID:33015023] [10.3389/fbioe.2020.571993] |
| 25. Junping Zheng, Yanlei Guo, Baifei Hu, Lin Zhu, Yong Yang, Shengrong Li, Na Li, Hongtao Liu. (2020) Serum metabolomic profiles reveal the impact of BuZangTongLuo formula on metabolic pathways in diabetic mice with hindlimb ischemia. JOURNAL OF ETHNOPHARMACOLOGY, 258 (112928). [PMID:32371144] [10.1016/j.jep.2020.112928] |
| 26. Junping Zheng, Man Chen, Cheng Ye, Xiongjie Sun, Nan Jiang, Xiaojuan Zou, Huabing Yang, Hongtao Liu. (2020) BuZangTongLuo decoction improved hindlimb ischemia by activating angiogenesis and regulating gut microbiota in diabetic mice. JOURNAL OF ETHNOPHARMACOLOGY, 248 (112330). [PMID:31654796] [10.1016/j.jep.2019.112330] |
| 27. Yang Zhang, Dongning Chai, Mengyue Gao, Bin Xu, Guohua Jiang. (2019) Thermal ablation of separable microneedles for transdermal delivery of metformin on diabetic rats. International Journal of Polymeric Materials and Polymeric Biomaterials, [10.1080/00914037.2018.1517347] |
| 28. Yongsheng Chen, Erpei Wang, Zihao Wei, Yanfang Zheng, Rian Yan, Xiang Ma. (2019) Phytochemical analysis, cellular antioxidant and α-glucosidase inhibitory activities of various herb plant organs. INDUSTRIAL CROPS AND PRODUCTS, 141 (111771). [10.1016/j.indcrop.2019.111771] |
| 29. Jing Chen, Guo Zheng, Hu Guo, Zhong-nan Shi, Jiao Jiang, Xiao-yu Wang, Xiao Yang, Xian-yu Liu. (2018) The effect of metformin treatment on endoplasmic reticulum (ER) stress induced by status epilepticus (SE) via the PERK-eIF2α-CHOP pathway. Bosnian Journal of Basic Medical Sciences, 18 (1): ( 49–54). [PMID:28686850] [10.17305/bjbms.2017.2044] |
| 30. Peng Mei, Huang Yanjun, Tao Ting, Peng Cai-Yun, Su Qiongli, Xu Wanjun, Darko Kwame Oteng, Tao Xiaojun, Yang Xiaoping. (2016) Metformin and gefitinib cooperate to inhibit bladder cancer growth via both AMPK and EGFR pathways joining at Akt and Erk. Scientific Reports, 6 (1): (1-10). [PMID:27334428] [10.1038/srep28611] |
| 31. Mei Peng, Qiongli Su, Qing Zeng, Le Li, Zhihong Liu, Lei Xue, Yan Cheng, Yanjun Huang, Ting Tao, Hongwei Lv, Xiaohui Li, Xiaojun Tao, Peng Guo, Alex F. Chen, Xiaoping Yang. (2016) High efficacy of intravesical treatment of metformin on bladder cancer in preclinical model. Oncotarget, 7 (8): ( 9102–9117). [PMID:26802022] [10.18632/oncotarget.6933] |
| 32. Qiongli Su,Ting Tao,Lei Tang,Jun Deng,Kwame Oteng Darko,Sichun Zhou,Mei Peng,Shanping He,Qing Zeng,Alex F Chen,Xiaoping Yang. (2018-03-08) Down-regulation of PKM2 enhances anticancer efficiency of THP on bladder cancer.. Journal of cellular and molecular medicine, 22 ((5)): (2774-2790). [PMID:29512924] |
| 33. Li Y, Zhao P, Chen Y, Fu Y, Shi K, Liu L, Liu H, Xiong M, Liu QH, Yang G, Xiao Y.. (2017) Depsidone and xanthones from Garcinia xanthochymus with hypoglycemic activity and the mechanism of promoting glucose uptake in L6 myotubes.. Bioorg Med Chem, 25 (24): (6605-6613). [PMID:29128163] [10.1016/j.bmc.2017.10.043] |