Necrostatin-1, 吲哚胺 2;3-二氧化酶 1 抑制剂；受体相互作用丝氨酸/苏氨酸激酶 1 抑制剂

TNF-alpha Inhibitors

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货号 (SKU)	包装规格	是否现货	价格	数量
N408034-1ml	1ml	现货

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Compound libraries (12326)

基本描述

别名	坏死抑制素-1
英文别名	Nec-1 \| 4-Imidazolidinone, 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-
规格或纯度	Moligand™, 10mM in DMSO
英文名称	Necrostatin-1
生化机理	Necrostatin-1（Nec-1）是一种特异性 RIP1（RIPK1）抑制剂，可抑制 TNF-α 诱导的坏死，在 293T 细胞中的 EC50 为 490 nM。Necrostatin-1 还能阻断 IDO，抑制自噬和细胞凋亡。
储存温度	-80℃储存
运输条件	超低温冰袋运输
作用类型	抑制剂
作用机制	吲哚胺 2;3-二氧化酶 1 抑制剂；受体相互作用丝氨酸/苏氨酸激酶 1 抑制剂
产品介绍	Information Necrostatin-1 Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 also blocks IDO and suppresses autophagy and apoptosis . In vitro Necrostatin-1 (1-100 μM) inhibits the autophosphorylation of overexpressed and endogenous RIP1.It is found RIP1 is the primary cellular target responsible for the antinecroptosis activity of Necrostatin-1. Necrostatin-1 efficiently suppresses necroptotic cell death triggered by an array of stimuli in a variety of cell types. Necrostatin-1, previously identified as small-molecule inhibitor of necroptosis, inhibits RIP kinase-induced necroptosis and inhibits TNF-α-induced necroptosis in jurkat cells with EC50 of 490 nM. In vivo Cell Data cell lines： Concentrations：0.01-100 μM Incubation Time：-- Powder Purity:≥99%

RIPK1 Tchem 受体相互作用丝氨酸/苏氨酸蛋白激酶 1(Receptor-interacting serine/threonine-protein kinase 1) (1 活性数据)

点击查看靶蛋白信息： RIPK1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

IDO1 Tchem 吲哚胺2,3-双加氧酶1(Indoleamine 2,3-dioxygenase 1) (1 活性数据)

点击查看靶蛋白信息： IDO1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

Canonical SMILES	CN1C(=O)C(CC2=C[NH]C3=CC=CC=C23)NC1=S
分子量	259.33

Concentration(Compounding value)	9.0-11.0(mmol/L)
Appearance(Yellow-green Liquid)	Pass
Record the entire process by video	Conform

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

1. Yao Li, Jie Wang, Yaru Li, Jiajia Luo, Fang Liu, Tiantian Chen, Yuting Ji, Hong Yang, Zheng Wang, Yanjun Zhao. (2023) Attenuating Uncontrolled Inflammation by Radical Trapping Chiral Polymer Micelles. ACS Nano, [PMID:37352508] [10.1021/acsnano.2c12356]

1. Yao Li, Jie Wang, Yaru Li, Jiajia Luo, Fang Liu, Tiantian Chen, Yuting Ji, Hong Yang, Zheng Wang, Yanjun Zhao. (2023) Attenuating Uncontrolled Inflammation by Radical Trapping Chiral Polymer Micelles. ACS Nano, [PMID:37352508] [10.1021/acsnano.2c12356]