| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| N407906-1ml |
1ml |
现货  |
|
| 英文别名 | Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452 | 3-Pyridinecarboxamide |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Nicotinamide (NSC 13128) |
| 生化机理 | 烟酰胺（NSC 13128，烟酰胺，维生素 PP，烟酸酰胺，维生素 B3，NSC 27452）是一种水溶性维生素，是辅酶 NAD 和 NADP 的活性成分，也是 sirtuins 的抑制剂。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Nicotinamide is a NAD+ and NADP+ coenzyme precursor. Nicotinamide is an antiinflammatory agent and a PARP-1 enzyme inhibitor.生化研究，配制组织培养基。 Information Nicotinamide (NSC 13128) Nicotinamide (NSC 13128, Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins . Nicotinamide strongly inhibits yeast silencing, increases rDNA recombination, and shortens replicative life span to that of a sir2 mutant. Nicotinamide abolishes silencing and leads to an eventual delocalization of Sir2 even in G(1)-arrested cells, demonstrating that silent heterochromatin requires continual Sir2 activity. Nicotinamide results in a twofold increase in DNA content and a threefold increase in insulin content in the fetal cells. Nicotinamide induces differentiation and maturation of human fetal pancreatic islet cells. Nicotinamide regulates sirtuins by switching between deacetylation and base exchange. Nicotinamide switching is quantitated for the Sir2s from Archeaglobus fulgidus (Sir2Af2), Saccharomyces cerevisiae (Sir2p), and mouse (Sir2alpha). Nicotinamide selectively reduces a specific phospho-species of tau (Thr231) that is associated with microtubule depolymerization in Alzheimer\'s disease transgenic mice, in a manner similar to inhibition of SirT1. Nicotinamide also dramatically increases acetylated alpha-tubulin, a primary substrate of SirT2, and MAP2c in Alzheimer\'s disease transgenic mice, both of which are linked to increased microtubule stability. Nicotinamide fosters DNA integrity and maintains phosphatidylserine membrane asymmetry to prevent cellular inflammation, cellular phagocytosis and vascular thrombosis. Nicotinamide both prevents and reverses neuronal and vascular cell injury. In vivo In the mouse, nicotinamide given i.p. at doses of 100-500 mg/kg showed biphasic elimination with dose-dependent changes in half-life. The initial half-life increased significantly (P <0.05) from 0.8 to 2 h and the terminal half-life increased from 3.4 to 5.6 h over the dose range studied. Clearance, however, decreased significantly from 0.3 to 0.24 L/kg/h only at the highest dose. Peak concentrations increased in a dose-dependent manner from 1,000 to 4,800 nmol/ml. The bioavailability given via the i.p. as compared with the i. v. route was close to 100%. cell lines： Concentrations：33 μM Incubation Time：7 days and 14 days Powder Purity:≥99% |
| Canonical SMILES | NC(=O)C1=CC=CN=C1 |
|---|---|
| 分子量 | 122.12 |
| Concentration | 9-11（mmol/L） |
|---|---|
| Proton NMR spectrum | Conforms to Structure |
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