N,N,N',N'-四(2-吡啶甲基)乙二胺

金属离子螯合剂

1篇引用文献

≥97%

CAS编号: 16858-02-9
分子式: C₂₆H₂₈N₆
分子量: 424.55
Beilstein号: 4211980
MDL号: MFCD00036918
PubChem编号: 5519
PubChem SID: 504750905

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货号 (SKU)	包装规格	是否现货
N159625-100mg	100mg	现货
N159625-250mg	250mg	现货
N159625-1g	1g	现货
N159625-5g	5g	现货

查看相关系列

Apoptosis (1467) Autophagy (555) Immunology/Inflammation (1941) Metabolic Enzyme/Protease (4888) NF-κB (753) Reactive Oxygen Species (316) 给氮配体 (229) 聚合物/高分子试剂 (681)

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基本描述

英文别名	1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)- \| HY-100202 \| N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine \| N,N,N',N'-Tetrakis(2-pyridyl-methyl)ethylenediamine \| N1,N1,N2,N2-Tetrakis(pyridin-2-ylmethyl)ethane-1,2-diamine \| BRD-K10385824-0
规格或纯度	≥97%
英文名称	N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine
生化机理	N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) elicits pro-apoptotic effect in human acute promyelocytic NB4 cells by inhibiting nitric oxide signalling and Zn2+ signaling.[1] In microglia pretreated with zinc, TPEN inhibits the interleukin 6 secretion and nitric oxide synthase (iNOS) mRNA expression.[2] It induces damage on DNA structure by activating ATM (ataxia telangiectasia mutated) and ATR (ATM-Rad3-related) signaling in human colon cancer cells. TPEN是一种可透过膜的锌螯合剂；可降低细胞内锌水平并诱导细胞凋亡（即细胞收缩和凋亡小体的形成、DNA片段化和形成典型的DNA梯状带）。金属离子螯合剂。降低细胞内锌水平。诱导细胞凋亡。导致卵母细胞成熟的缺陷。癫痫发作后调节海马神经发生。细胞可渗透。在体内和体外具有活性。
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

关联靶点（人）

MOLT-4 (49676 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 活性数据)

点击查看靶蛋白信息： TDP1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SMN1 Tchem Survival motor neuron protein (34246 活性数据)

点击查看靶蛋白信息： SMN1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

HSPA5 Tchem 78 kDa glucose-regulated protein (3319 活性数据)

点击查看靶蛋白信息： HSPA5

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Staphylococcus aureus (210822 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Staphylococcus epidermidis (22802 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Citrobacter freundii (1864 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Enterococcus faecium (13803 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Enterococcus faecalis (29875 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

PC-12 (7051 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 活性数据)

点击查看靶蛋白信息： Mapt

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Impa1 Inositol monophosphatase 1 (16203 活性数据)

点击查看靶蛋白信息： Impa1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Lin28a Protein lin-28 homolog A (33 活性数据)

点击查看靶蛋白信息： Lin28a

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Vero C1008 (1716 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	504750905
分子类型	小分子
IUPAC Name	N,N,N',N'-tetrakis(pyridin-2-ylmethyl)ethane-1,2-diamine
INCHI	InChI=1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2
InChi Key	CVRXLMUYFMERMJ-UHFFFAOYSA-N
Canonical SMILES	C1=CC=NC(=C1)CN(CCN(CC2=CC=CC=N2)CC3=CC=CC=N3)CC4=CC=CC=N4
Isomeric SMILES	C1=CC=NC(=C1)CN(CCN(CC2=CC=CC=N2)CC3=CC=CC=N3)CC4=CC=CC=N4
WGK Germany	3
PubChem CID	5519
分子量	424.55
Beilstein号	4211980
Reaxy-Rn	4211982

化学和物理性质

溶解性	可溶于甲醇
熔点	112 °C(dec.)
分子量	424.500 g/mol
XLogP3	2.100
氢键供体数Hydrogen Bond Donor Count	0
氢键受体数Hydrogen Bond Acceptor Count	6
可旋转键计数Rotatable Bond Count	11
精确质量Exact Mass	424.238 Da
单同位素质量Monoisotopic Mass	424.238 Da
拓扑极表面积Topological Polar Surface Area	58.000 Å²
重原子数Heavy Atom Count	32
形式电荷Formal Charge	0
复杂度Complexity	419.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS07
信号词	Warning
危险声明	H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany	3
Reaxy-Rn	4211982
个人防护装备	dust mask type N95 (US)， Eyeshields， Gloves

SDS英文版

质量标准

Purity(NonaqueousTitration)	96.5-103.5（%）
Appearance（N159625)	White to Light yellow to Brown powder to crystal
Proton NMR spectrum	Conforms to Structure

质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到8个结果

批号(Lot Number)	证书类型	日期	货号
F2421353	分析证书	24-07-01	N159625
F2229555	分析证书	22-07-03	N159625
F2229556	分析证书	22-07-03	N159625
F2229557	分析证书	22-07-03	N159625
B2515089	分析证书	22-07-03	N159625
H2211461	分析证书	22-07-02	N159625
H2211515	分析证书	22-07-02	N159625
H2211523	分析证书	22-07-02	N159625

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1. Yan Liang, Jinjin Wang, Chenlu Xu, Wenshuai Han, Sixuan Wu, Yonghua Wu, Jingge Zhang, Junjie Liu, Zhenzhong Zhang, Jinjin Shi, Kaixiang Zhang. (2023) Remodeling Collagen Microenvironment in Liver Using a Biomimetic Nano-Regulator for Reversal of Liver Fibrosis. Advanced Science, (2300127). [PMID:37088730] [10.1002/advs.202300127]

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