| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab170487-100μg |
100μg |
期货  |
| |
| Ab170487-1mg |
1mg |
现货 |
| |
| Ab170487-5mg |
5mg |
现货 |
| |
| Ab170487-10mg |
10mg |
期货 |
|
| 产品名称 | Mupadolimab (anti-CD73), 外-5'-核苷酸酶抗体 |
|---|---|
| 别名 | 莫帕利单抗 | 莫帕多利单抗(抗 CD73) |
| 英文别名 | 5' nucleotidase (CD73) | 5'-NT | 5-NT | 5'-Nucleotidase | 5'-nucleotidase, ecto (CD73) | CD73 antigen | CD73 | E5NT | EC 3.1.3.5 | ecto-5'-nucleotidase | eN | eNT | NT | NT55'-nucleotidase | NT5E | NTE | Purine 5-Prime-Nucleotidase | 5' NT antibody | 5' n |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | NT5E / CD73 |
| 应用 | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
| 种属反应性 | 人(Human) |
| 偶联 | Unconjugated |
| 作用类型 | 抗体 |
| 作用机制 | 外-5'-核苷酸酶抗体 |
| 抗体类型 | Primary antibody |
|---|---|
| 克隆类型 | 重组抗体 |
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | kappa |
| SDS-PAGE | 31.1 kDa (Light Chain) & 54.6 kDa (Heavy Chain), under reducing conditions; 188.5 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 来源 | CHO supernatant |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 2451856-97-4 |
| 分子类型 | 抗体 |
Mupadolimab (anti-CD73) (Ab170487) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling CD73 (red) with Mupadolimab (anti-CD73) (Ab170487) . Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Mupadolimab (anti-CD73) (Ab170487) - SEC
The purity of Mupadolimab (anti-CD73) (Ab170487) is more than 95% verified by HPLC.
Mupadolimab (anti-CD73) (Ab170487) - ELISA
Immobilized hu-NT5E-ECD-chis at 2 μg/mL can bind Mupadolimab (anti-CD73) (Ab170487) with the EC₅₀ of 9.89 ng/mL.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 ZJ23F0900993 |
分析证书 | 23-09-11 | Ab170487 |
| ZJ23F0900992 |
分析证书 | 23-09-11 | Ab170487 |
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| 1. Geoghegan JC, Diedrich G, Lu X, Rosenthal K, Sachsenmeier KF, Wu H, Dall'Acqua WF, Damschroder MM. (2016) Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action.. MAbs, 8 (3): (454-67). [PMID:26854859] |
| 2. Eliahu S, Lecka J, Reiser G, Haas M, Bigonnesse F, Lévesque SA, Pelletier J, Sévigny J, Fischer B.. (2010) Diadenosine 5',5''-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors.. J Med Chem, 53 (24): (8485-8497). [PMID:21090681] [10.1021/jm100597c] |
| 3. al-Rashida M, Raza R, Abbas G, Shah MS, Kostakis GE, Lecka J, Sévigny J, Muddassar M, Papatriantafyllopoulou C, Iqbal J.. (2013) Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases.. Eur J Med Chem, 66 (438-449). [PMID:23831808] [10.1016/j.ejmech.2013.06.015] |
| 4. Gillerman I, Lecka J, Simhaev L, Munkonda MN, Fausther M, Martín-Satué M, Senderowitz H, Sévigny J, Fischer B.. (2014) 2-Hexylthio-β,γ-CH2-ATP is an effective and selective NTPDase2 inhibitor.. J Med Chem, 57 (14): (5919-5934). [PMID:24972256] [10.1021/jm401933c] |
| 5. Lee SY, Perotti A, De Jonghe S, Herdewijn P, Hanck T, Müller CE.. (2016) Thiazolo[3,2-a]benzimidazol-3(2H)-one derivatives: Structure-activity relationships of selective nucleotide pyrophosphatase/phosphodiesterase1 (NPP1) inhibitors.. Bioorg Med Chem, 24 (14): (3157-3165). [PMID:27265686] [10.1016/j.bmc.2016.05.046] |
| 6. Abdel-Magid AF.. (2017) Inhibitors of CD73 May Provide a Treatment for Cancer and Autoimmune Diseases.. ACS Med Chem Lett, 8 (8): (781-782). [PMID:28835785] [10.1021/acsmedchemlett.7b00255] |
| 7. Junker A, Renn C, Dobelmann C, Namasivayam V, Jain S, Losenkova K, Irjala H, Duca S, Balasubramanian R, Chakraborty S, Börgel F, Zimmermann H, Yegutkin GG, Müller CE, Jacobson KA.. (2019) Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) Inhibitors.. J Med Chem, 62 (7): (3677-3695). [PMID:30895781] [10.1021/acs.jmedchem.9b00164] |
| 8. Du X,Moore J,Blank BR,Eksterowicz J,Sutimantanapi D,Yuen N,Metzger T,Chan B,Huang T,Chen X,Chen Y,Duong F,Kong W,Chang JH,Sun J,Zavorotinskaya T,Ye Q,Junttila MR,Ndubaku C,Friedman LS,Fantin VR,Sun D. (2020) Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production.. J Med Chem, 63 (18): (10433-10459). [PMID:32865411] [10.1021/acs.jmedchem.0c01086] |
| 9. Misumi, Y Y, Ogata, S S, Ohkubo, K K, Hirose, S S and Ikehara, Y Y.. (1990) Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form.. European journal of biochemistry, (17): [PMID:2129526] |
| 10. Klemens, M R MR and 5 more authors.. (1990) Characterization of soluble vs membrane-bound human placental 5'-nucleotidase.. Biochemical and biophysical research communications, (15): [PMID:2173922] |
| 11. Hansen, K R KR, Resta, R R, Webb, C F CF and Thompson, L F LF.. (1995) Isolation and characterization of the promoter of the human 5'-nucleotidase (CD73)-encoding gene.. Gene, (29): [PMID:8566797] |
| 12. Otsuki, Tetsuji T and 24 more authors.. (2005) Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.. DNA research : an international journal for rapid publication of reports on genes and genomes, [PMID:16303743] |
| 13. Ustunsoy, Hasim H and 5 more authors.. The effects of pentoxifylline on the myocardial inflammation and ischemia-reperfusion injury during cardiopulmonary bypass.. Journal of cardiac surgery, [PMID:16426349] |
| 14. Wollscheid, Bernd B and 7 more authors.. (2009) Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.. Nature biotechnology, [PMID:19349973] |
| 15. St Hilaire, Cynthia C and 20 more authors.. (2011) NT5E mutations and arterial calcifications.. The New England journal of medicine, (3): [PMID:21288095] |
| 16. Garavaglia, Silvia S and 9 more authors.. (2012) The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism.. The Biochemical journal, (1): [PMID:21933152] |
| 17. Heuts, Dominic P H M DP and 6 more authors.. (2012) Crystal structure of a soluble form of human CD73 with ecto-5'-nucleotidase activity.. Chembiochem : a European journal of chemical biology, (5): [PMID:22997138] |
| 18. Knapp, Karen K and 5 more authors.. (2012) Crystal structure of the human ecto-5'-nucleotidase (CD73): insights into the regulation of purinergic signaling.. Structure (London, England : 1993), (5): [PMID:23142347] |
| 19. Fausther, Michel M, Lavoie, Elise G EG, Goree, Jessica R JR, Baldini, Giulia G and Dranoff, Jonathan A JA.. (2014) NT5E mutations that cause human disease are associated with intracellular mistrafficking of NT5E protein.. PloS one, [PMID:24887587] |
| 20. Channar, Pervaiz Ali PA and 8 more authors.. (2017) Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5'-nucleotidase.. Chemical biology & drug design, [PMID:27589035] |
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