| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M422082-1ml |
1ml |
现货  |
|
| 别名 | 化合物401 | 2-吗啉基-4H-嘧啶并[2,1-a]异喹啉-4-酮 |
|---|---|
| 英文别名 | Compound 401 | 168425-64-7 | 2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one | 2-(morpholin-4-yl)pyrimido[2,1-a]isoquinolin-4-one | TN9PWB4UM5 | CHEMBL179242 | 2-(4-MORPHOLINYL)-4H-PYRIMIDO[2,1-A]ISOQUINOLIN-4-ONE | 2-morpholin-4-ylpyrimido[2,1-a]isoquinolin-4-one | 2-M |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | 2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one |
| 生化机理 | 选择性，可逆DNA依赖性蛋白激酶和mTOR抑制剂（IC 50值分别为0.28和5.3μM）。对PI3K，ATM和ATR没有亲和力（IC 50值> 100μM）。能够诱导体外细胞凋亡。细胞可渗透的。 |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Product Introduction A cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 µM). Exhibits much reduced or no activity against 43 other commonly studied kinases, including PI 3-K, ATM, and ATR. Shown to induce apoptosis and inhibit mTOR-dependent growth in TSC1-/- murine embryo fibroblasts. |
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 2-morpholin-4-ylpyrimido[2,1-a]isoquinolin-4-one |
| INCHI | InChI=1S/C16H15N3O2/c20-15-11-14(18-7-9-21-10-8-18)17-16-13-4-2-1-3-12(13)5-6-19(15)16/h1-6,11H,7-10H2 |
| InChi Key | BVRDQVRQVGRNHG-UHFFFAOYSA-N |
| Canonical SMILES | C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2 |
| Isomeric SMILES | C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2 |
| 分子量 | 281.32 |
| Reaxy-Rn | 7138986 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7138986&ln= |
| 敏感性 | 对热、光线敏感 |
|---|---|
| 熔点 | 214 °C |
| 分子量 | 281.310 g/mol |
| XLogP3 | 1.200 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 1 |
| 精确质量Exact Mass | 281.116 Da |
| 单同位素质量Monoisotopic Mass | 281.116 Da |
| 拓扑极表面积Topological Polar Surface Area | 45.100 Ų |
| 重原子数Heavy Atom Count | 21 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 532.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| Reaxy-Rn | 7138986 |
|---|---|
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7138986&ln= |
| Concentration(Compounding value) | 9.0-11.0(mmol/L) |
|---|---|
| Appearance(Colorless Transparent Liquid) | Pass |
| Record the entire process by video | Conform |
首页
400-620-6333
