计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M303130-250mg |
250mg |
现货 ![]() |
| |
| M303130-1g |
1g |
现货 ![]() |
| |
| M303130-5g |
5g |
现货 ![]() |
| |
| M303130-25g |
25g |
期货 ![]() |
|
| 别名 | 霉康唑 | (±)-1-[2-(2,4-二氯苄氧基)-2-(2,4-二氯苯基)乙基]-1H-咪唑 |
|---|---|
| 英文别名 | Miconazole (USP:INN:BAN:JAN) | MICONAZOLE [EP MONOGRAPH] | MJR 1762 | Dactarin | DTXSID6023319 | NSC 170986 | UNII-7NNO0D7S5M | (RS)-miconazole | 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]- | Prestwick3_000067 | (+-)-Mic |
| 规格或纯度 | Moligand™, ≥98% |
| 英文名称 | Miconazole |
| 生化机理 | 抗真菌剂。芳香酶抑制剂。通用的P450抑制剂。在体内显示出抗血管生成和抗肿瘤作用。口服具有活性 |
| 储存温度 | 避光,-20°C储存,干燥 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 细胞色素 P450 51 抑制剂 |
| 产品介绍 |
Application Miconazole, is used as an antifungal inhibitor of aromatase. Miconazole has been shown to promote remyelination of neurons in chronic progressive multiple sclerosis mouse models. Miconazole is mainly used externally for the treatment of athlete's foot, ringworm, and jock itch. Internal application is used for oral or vaginal thrush (yeast infection). The oral gel may also be used for the lip disorder angular cheilitis. It is also used in photography |
| ALogP | 5.3 |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 504750757 |
|---|---|
| 分子类型 | 小分子 |
| IUPAC Name | 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole |
| INCHI | InChI=1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2 |
| InChi Key | BYBLEWFAAKGYCD-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl |
| Isomeric SMILES | C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl |
| PubChem CID | 4189 |
| 分子量 | 416.14 |
| 溶解性 | Freely soluble in alcohols or acetone. Also soluble in DMF or chloroform. |
|---|---|
| 敏感性 | 对光敏感 |
| 熔点 | 83-97°C |
| 分子量 | 416.100 g/mol |
| XLogP3 | 5.300 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 2 |
| 可旋转键计数Rotatable Bond Count | 6 |
| 精确质量Exact Mass | 415.983 Da |
| 单同位素质量Monoisotopic Mass | 413.986 Da |
| 拓扑极表面积Topological Polar Surface Area | 27.100 Ų |
| 重原子数Heavy Atom Count | 25 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 417.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 1 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| NMR Spectrum 1H | Conforms to Structure |
|---|---|
| LC-MS for identification | Conforms |
| Purity(HPLC area) |
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| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
| 分析证书 | 24-02-27 | M303130 | |
| 分析证书 | 24-02-27 | M303130 | |
| 分析证书 | 24-02-27 | M303130 | |
| 分析证书 | 24-02-27 | M303130 | |
| 分析证书 | 24-02-27 | M303130 | |
| 分析证书 | 24-02-27 | M303130 | |
| 分析证书 | 24-02-27 | M303130 | |
| 分析证书 | 24-02-27 | M303130 | |
| 分析证书 | 23-07-10 | M303130 | |
| 分析证书 | 23-07-10 | M303130 | |
| 分析证书 | 23-07-10 | M303130 | |
| 分析证书 | 23-07-10 | M303130 | |
| 分析证书 | 23-04-27 | M303130 | |
| 分析证书 | 23-04-27 | M303130 |
| 1. Xu Yang-ding, Guo Yu-jie, Mao He-rong, Xiong Zhi-xiang, Luo Meng-yu, Luo Rui-qi, Lu Shan, Huang Lu, Hong Yi. (2023) Integration of transcriptomics and proteomics to elucidate inhibitory effect and mechanism of rosmarinic acid from Perilla frutescens (L.) Britt. in treating Trichophyton mentagrophytes. Chinese Medicine, 18 (1): (1-20). [PMID:37280712] [10.1186/s13020-023-00772-2] |
| 2. Kamran Bashir, Zhimin Luo, Guoning Chen, Hua Shu, Xia Cui, Wen Li, Wang Lu, Qiang Fu. (2020) Development of Surface Molecularly Imprinted Polymers as Dispersive Solid Phase Extraction Coupled with HPLC Method for the Removal and Detection of Griseofulvin in Surface Water. International Journal of Environmental Research and Public Health, 17 (1): (134). [PMID:31878121] [10.3390/ijerph17010134] |
| 1. Xu Yang-ding, Guo Yu-jie, Mao He-rong, Xiong Zhi-xiang, Luo Meng-yu, Luo Rui-qi, Lu Shan, Huang Lu, Hong Yi. (2023) Integration of transcriptomics and proteomics to elucidate inhibitory effect and mechanism of rosmarinic acid from Perilla frutescens (L.) Britt. in treating Trichophyton mentagrophytes. Chinese Medicine, 18 (1): (1-20). [PMID:37280712] [10.1186/s13020-023-00772-2] |
| 2. Kamran Bashir, Zhimin Luo, Guoning Chen, Hua Shu, Xia Cui, Wen Li, Wang Lu, Qiang Fu. (2020) Development of Surface Molecularly Imprinted Polymers as Dispersive Solid Phase Extraction Coupled with HPLC Method for the Removal and Detection of Griseofulvin in Surface Water. International Journal of Environmental Research and Public Health, 17 (1): (134). [PMID:31878121] [10.3390/ijerph17010134] |