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2-吗啉代-8-苯基色酮

PI3-激酶抑制剂
12篇引用文献
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货号 (SKU) 包装规格 是否现货 价格 数量
L124970-10mg
 10mg 现货 Stock Image
L124970-25mg
 25mg 现货 Stock Image
L124970-50mg
 50mg 现货 Stock Image
L124970-100mg
 100mg 现货 Stock Image
L124970-250mg
 250mg 现货 Stock Image
L124970-500mg
 500mg 现货 Stock Image
大包装询价 收藏夹 比较  SDS中文版  DATASHEET
查看相关系列
Apoptosis (1467) Autophagy (555) Casein Kinase (72) Cell Cycle/DNA Damage (2603) DNA-PK (29) PI3K (243) PI3K/Akt/mTOR (764) PI3K抑制剂 (1) Stem Cell/Wnt (1018) 六元杂环化合物 (1702) 吗啉类 (126) 吡喃类 (21) 色酮类 (1)
main product photo

基本描述

别名 8-苯基-2-(吗啉-4-基)色原酮 | 2-吗啉代-8-苯基-4-氧代-4H-1-苯并吡喃
英文别名 SCHEMBL94377 | 31M2U1DVID | J-510126 | NCGC00015622-07 | s1105 | BiomolKI_000029 | DTXSID6042650 | EC-000.2341 | CS-0150 | NCGC00015622-04 | NCI60_034712 | UNII-31M2U1DVID | 2-morpholino-8-phenyl-4H-chromen-4-one | 2-Morpholino-8-phenylchromone | CZQHHVNH
规格或纯度 Moligand™, ≥98%
英文名称 LY294002
生化机理 LY294002 是 PI 3-kinase 的强效抑制剂，PI 3-kinase 是细胞间信号调节酶家族中的磷酸肌醇 3-kinase 蛋白。该化合物对 PI 3-kinase p110 β（PI 3-Kβ）和 PI 3-kinase p110 α（PI 3-Kα）具有选择性，但在较高浓度下会抑制其他 PI 3 激酶（PI 3-Kβ 和 PI 3-Kα 的 IC50 分别为 310 nM 和 730 nM）。与这些受体相关的途径与癌症和糖尿病有关，LY294002 是研究这种关系的重要工具。有报告显示，LY294002 通过阻断与癌症存活和增殖密切相关的 PI 3-kinase/Akt 信号通路，促进此类细胞的凋亡。LY 294002 是 Pim-1、PI 3-kinase p110 δ 和 PI 3-kinase p110 γ 的抑制剂，是磷脂酰肌醇 3-kinase 的高选择性抑制剂（IC 50 = 1.4 μM）。对一系列其他激酶具有选择性，包括蛋白激酶 C、蛋白激酶 A、MAPK 和 PI4- 激酶（IC 50 > 50 μM）。
储存温度 -20°C储存
运输条件 超低温冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

LY294002是第一个人工合成的PI3Kα/δ/β的抑制剂，IC50分别为0.5 μM/0.57 μM/0.97 μM，在溶液中比在Wortmannin中稳定，也能够抑制自噬体的形成。A potent blocker of PI 3-kinase/Akt signaling.

LY294002 is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation.
A potent blocker of PI 3-kinase/Akt signaling.

关联靶点（人）

CYP1A2 Tchem 细胞色素 P450 1A2(Cytochrome P450 1A2) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
BRD4 Tchem 含溴结构域蛋白 4(Bromodomain-containing protein 4) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PIK3CA Tclin 磷脂酰肌醇 4,5-双磷酸 3-激酶催化亚基 α 异构体(Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PIK3CB Tchem 磷脂酰肌醇 4,5-双磷酸 3-激酶催化亚基 β 异构体(Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PIK3CD Tclin 磷脂酰肌醇 4,5-双磷酸 3-激酶催化亚基 delta 异构体(Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
BRD3 Tchem 含溴结构域蛋白 3(Bromodomain-containing protein 3) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
BRD2 Tchem 含溴结构域蛋白 2(Bromodomain-containing protein 2) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PDE5A Tclin Phosphodiesterase 5A (5113 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ABL1 Tclin Tyrosine-protein kinase ABL (18331 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
INSR Tclin Insulin receptor (5558 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR4 Tclin Serotonin 4 (5-HT4) receptor (2068 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ESR2 Tclin Estrogen receptor beta (9272 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 (2118 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Sigmar1 Sigma opioid receptor (160 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cruzipain (33337 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cckar Cholecystokinin A receptor (90 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PIK3CA PI3-kinase p110-alpha subunit (51 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDE2A Phosphodiesterase 2A (77 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Prkcd Protein kinase C delta (192 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Prkcb Protein kinase C beta (2 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Fgfr4 Fibroblast growth factor receptor 4 (138 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pkm Pyruvate kinase isozymes M1/M2 (66 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Camk2g CaM kinase II gamma (1 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Tec Tyrosine-protein kinase TEC (25 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hepatitis C virus (23859 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RBL-2H3 (1162 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
H4 (48 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
J774 (3120 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mast cell (119 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Danio rerio (3092 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Glra2 Glycine receptor (1745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CACNA1C L-type calcium channel alpha 1C/beta 2A (2 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Zaire ebolavirus (77 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Junin virus (193 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 488179813
分子类型 小分子
IUPAC Name 2-morpholin-4-yl-8-phenylchromen-4-one
INCHI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChi Key CZQHHVNHHHRRDU-UHFFFAOYSA-N
Canonical SMILES C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4
Isomeric SMILES C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4
分子量 307.35
Reaxy-Rn 8156139
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8156139&ln=

化学和物理性质

溶解性 Soluble in DMSO (25 mg/ml warm), ethanol (25 mg/ml warm), chloroform, water (< 50 ug/ml) at 25 °C, PBS pH 7.2 (< 50 ug/ml), DMF (~16 mg/ml ), and DMSO:PBS(1:1, pH 7.2) (~0.5 mg/ml ).
敏感性 对热敏感
熔点 184 °C
分子量 307.300 g/mol
XLogP3 3.100
氢键供体数Hydrogen Bond Donor Count 0
氢键受体数Hydrogen Bond Acceptor Count 4
可旋转键计数Rotatable Bond Count 2
精确质量Exact Mass 307.121 Da
单同位素质量Monoisotopic Mass 307.121 Da
拓扑极表面积Topological Polar Surface Area 38.800 Ų
重原子数Heavy Atom Count 23
形式电荷Formal Charge 0
复杂度Complexity 463.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

Reaxy-Rn 8156139
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8156139&ln=

 SDS英文版

质量标准

Purity(HPLC) 98-100（%）
Nitrogen by Elemental Analysis 4.4-4.7（%）
Melting point 182-186（℃）
Appearance（L124970) White to Light Yellow Powder or Crystals
Proton NMR spectrum Conforms to Structure

 质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到38个结果

批号(Lot Number) 证书类型 日期 货号
E2322306 分析证书 25-03-04 L124970
E2322308 分析证书 25-03-04 L124970
E2322341 分析证书 25-03-04 L124970
E2322259 分析证书 25-03-04 L124970
E2322269 分析证书 25-03-04 L124970
E2322283 分析证书 25-03-04 L124970
E2322284 分析证书 25-03-04 L124970
E2322301 分析证书 25-03-04 L124970
E2322305 分析证书 25-03-04 L124970
C2323005 分析证书 25-01-09 L124970
H2427172 分析证书 24-08-14 L124970
H2427173 分析证书 24-08-14 L124970
H2427175 分析证书 24-08-14 L124970
I2224270 分析证书 24-07-04 L124970
A2429186 分析证书 24-01-12 L124970
A2429188 分析证书 24-01-12 L124970
A2429189 分析证书 24-01-12 L124970
A2429190 分析证书 24-01-12 L124970
A2429191 分析证书 24-01-12 L124970
A2429192 分析证书 24-01-12 L124970
A2429194 分析证书 24-01-12 L124970
A2429195 分析证书 24-01-12 L124970
A2429196 分析证书 24-01-12 L124970
A2429197 分析证书 24-01-12 L124970
A2429198 分析证书 24-01-12 L124970
A2429199 分析证书 24-01-12 L124970
I2118363 分析证书 24-01-02 L124970
K2309263 分析证书 23-10-25 L124970
K2309264 分析证书 23-10-25 L124970
K2309265 分析证书 23-10-25 L124970
K2309266 分析证书 23-10-25 L124970
I2118361 分析证书 23-07-07 L124970
E2322278 分析证书 23-04-27 L124970
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1. Wu N et al..  (2021)  Berberine ameliorates neuronal AD-like change via activating Pi3k/PGCε pathway..  Biofactors,  47  (4): (587-599).  [PMID:33740285]
2. Xiu Yanghui, Su Yu, Gao Lihua, Yuan Hui, Xu Sennan, Liu Ying, Qiu Yan, Liu Zhen, Li Yuhang.  (2023)  Corylin accelerated wound healing through SIRT1 and PI3K/AKT signaling: a candidate remedy for chronic non-healing wounds.  Frontiers in Pharmacology,  14  [PMID:37266148] [10.3389/fphar.2023.1153810]
3. Na Li, Fanghan He, Yunxiao Shang.  (2023)  Growth differentiation factor 15 protects the airway by inhibiting cell pyroptosis in obese asthmatic mice through the phosphoinositide 3-kinase/AKT pathway.  INTERNATIONAL IMMUNOPHARMACOLOGY,  119  (110149).  [PMID:37058747] [10.1016/j.intimp.2023.110149]
4. Xuanhao Fu, Boyuan Ma, Mengmeng Zhou, Yuelin Cheng, Linyan Liu, Shunli Kan, Chengjiang Liu, Xinyan Zhao, Sa Feng, Haoqiang Zhu, Wei Hu, Zehua Jiang, Rusen Zhu.  (2023)  Network pharmacology integrated with experimental validation to explore the therapeutic role and potential mechanism of Epimedium for spinal cord injury.  Frontiers in Molecular Neuroscience,  16  (1074703).  [PMID:36793356] [10.3389/fnmol.2023.1074703]
5. Qin Yeyu, Xie Jing, Zheng Ruihe, Li Yuhang, Wang Haixia.  (2022)  Oleoylethanolamide as a New Therapeutic Strategy to Alleviate Doxorubicin-Induced Cardiotoxicity.  Frontiers in Pharmacology,  13  [PMID:35517792] [10.3389/fphar.2022.863322]
6. Na Wei, Tan Lu, Libin Yang, Yonghan Dong, Xiaotan Liu.  (2021)  Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.  FEBS Open Bio,  11  (8): (2118-2126).  [PMID:34048148] [10.1002/2211-5463.13203]
7. Hu Gaowei, Miao Yingjie, Luo Xi, Chu Wenhui, Fu Yongqian.  (2020)  Identification of a novel cell-penetrating peptide derived from the capsid protein of chicken anemia virus and its application in gene delivery.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,  104  (24): (10503-10513).  [PMID:33141296] [10.1007/s00253-020-10988-z]
8. Chen Danping, Wang Yang, Mo Mingming, Zhang Junjie, Zhang Yanfei, Xu Yuzhi, Liu Si-Yang, Chen Jun, Ma Yingjun, Zhang Li, Dai Zong, Cai Chun, Zou Xiaoyong.  (2019)  Polymerization retardation isothermal amplification (PRIA): a strategy enables sensitively quantify genome-wide 5-methylcytosine oxides rapidly on handy instruments with nanoscale sample input.  NUCLEIC ACIDS RESEARCH,  47  (19): (e119-e119).  [PMID:31418020] [10.1093/nar/gkz704]
9. Hu Gaowei, Zheng Wenlv, Li Ao, Mu Yaru, Shi Mingyu, Li Tuofan, Zou Haitao, Shao Hongxia, Qin Aijian, Ye Jianqiang.  (2018)  A novel CAV derived cell-penetrating peptide efficiently delivers exogenous molecules through caveolae-mediated endocytosis.  VETERINARY RESEARCH,  49  (1): (1-9).  [PMID:29439726] [10.1186/s13567-018-0513-2]
10. Xiaofei Li, Jian Li, Zhike Li, Ying Sang, Yunhui Niu, Qianying Zhang, Hong Ding, Shanye Yin.  (2016)  Fucoidan from Undaria pinnatifida prevents vascular dysfunction through PI3K/Akt/eNOS-dependent mechanisms in the L-NAME-induced hypertensive rat model.  Food & Function,  7  (5): (2398-2408).  [PMID:27153123] [10.1039/C6FO00288A]
11. Liu Di, Guo Hua, Zheng Wenyun, Zhang Na, Wang Tianwen, Wang Ping, Ma Xingyuan.  (2016)  Discovery of the cell-penetrating function of A2 domain derived from LTA subunit of Escherichia coli heat-labile enterotoxin.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,  100  (11): (5079-5088).  [PMID:26960316] [10.1007/s00253-016-7423-x]
12. Jing Zhao, Li Li, Ling Peng.  (2015)  MAPK1 up-regulates the expression of MALAT1 to promote the proliferation of cardiomyocytes through PI3K/AKT signaling pathway.  International Journal of Clinical and Experimental Pathology,  8  (12): ( 15947–15953).  [PMID:26884868]

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44. Hu Gaowei, Miao Yingjie, Luo Xi, Chu Wenhui, Fu Yongqian.  (2020)  Identification of a novel cell-penetrating peptide derived from the capsid protein of chicken anemia virus and its application in gene delivery.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,  104  (24): (10503-10513).  [PMID:33141296] [10.1007/s00253-020-10988-z]
45. Chen Danping, Wang Yang, Mo Mingming, Zhang Junjie, Zhang Yanfei, Xu Yuzhi, Liu Si-Yang, Chen Jun, Ma Yingjun, Zhang Li, Dai Zong, Cai Chun, Zou Xiaoyong.  (2019)  Polymerization retardation isothermal amplification (PRIA): a strategy enables sensitively quantify genome-wide 5-methylcytosine oxides rapidly on handy instruments with nanoscale sample input.  NUCLEIC ACIDS RESEARCH,  47  (19): (e119-e119).  [PMID:31418020] [10.1093/nar/gkz704]
46. Hu Gaowei, Zheng Wenlv, Li Ao, Mu Yaru, Shi Mingyu, Li Tuofan, Zou Haitao, Shao Hongxia, Qin Aijian, Ye Jianqiang.  (2018)  A novel CAV derived cell-penetrating peptide efficiently delivers exogenous molecules through caveolae-mediated endocytosis.  VETERINARY RESEARCH,  49  (1): (1-9).  [PMID:29439726] [10.1186/s13567-018-0513-2]
47. Xiaofei Li, Jian Li, Zhike Li, Ying Sang, Yunhui Niu, Qianying Zhang, Hong Ding, Shanye Yin.  (2016)  Fucoidan from Undaria pinnatifida prevents vascular dysfunction through PI3K/Akt/eNOS-dependent mechanisms in the L-NAME-induced hypertensive rat model.  Food & Function,  7  (5): (2398-2408).  [PMID:27153123] [10.1039/C6FO00288A]
48. Liu Di, Guo Hua, Zheng Wenyun, Zhang Na, Wang Tianwen, Wang Ping, Ma Xingyuan.  (2016)  Discovery of the cell-penetrating function of A2 domain derived from LTA subunit of Escherichia coli heat-labile enterotoxin.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,  100  (11): (5079-5088).  [PMID:26960316] [10.1007/s00253-016-7423-x]
49. Jing Zhao, Li Li, Ling Peng.  (2015)  MAPK1 up-regulates the expression of MALAT1 to promote the proliferation of cardiomyocytes through PI3K/AKT signaling pathway.  International Journal of Clinical and Experimental Pathology,  8  (12): ( 15947–15953).  [PMID:26884868]

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