KB-5492 free base

10mM in DMSO

CAS编号: 113594-64-2(DMSO)
分子式: C₂₃H₃₀N₂O₆
分子量: 430.49

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货号 (SKU)	包装规格	是否现货	价格	数量
K655355-1ml	1ml	期货

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Compound libraries (12326) σ受体 (61) 神经元信号传导 (3329)

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基本描述

别名	KB-5492 游离碱
规格或纯度	10mM in DMSO
英文名称	KB-5492 free base
生化机理	KB-5492 游离碱是一种强效的σ受体选择性抑制剂，可抑制[3 H]1,3-二（2-甲苯基）胍（DTG）与σ受体的特异性结合，IC 50 为 3.15 μM。KB-5492 游离碱是一种抗溃疡剂。
储存温度	-80℃储存
运输条件	超低温冰袋运输
产品介绍	KB-5492 free base is a potent and selective inhibitor of sigma receptor , inhibits specific [ 3 H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC 50 of 3.15 μM. KB-5492 free base is an anti-ulcer agent In Vitro KB-5492 (0.001-100 μM) free base inhibits specific [ 3 H]DTG binding in a concentration-dependent manner. KB-5492 (0.1-1 mM) free base significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in 51 Cr release from gastric epithelial cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo KB-5492 (200 mg/kg; p.o.) free base prevents macroscopic lesions in the gastric mucosa. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damageDosage: 200 mg/kg Administration: Oral gavage Result: Reduced the lesion length as compared with the control. Prevented the deep mucosal lesions and exfoliation of surface epithelial cells. IC50& Target:IC50: 3.15 μM (sigma receptor)