| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| J655309-1ml |
1ml |
期货  |
|
| 规格或纯度 | 10mM in DMSO |
|---|---|
| 英文名称 | JH-VIII-157-02 |
| 生化机理 | JH-VIII-157-02是阿来替尼的结构类似物，是一种ALK抑制剂，对细胞中棘皮动物微管相关蛋白样4-ALK（EML4-ALK）G1202R的IC50为2 nM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
JH-VIII-157-02 is a structural analogue of alectinib, acts as an ALK inhibitor, and shows an IC 50 of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells. In Vitro JH-VIII-157-02 is a structural analogue of alectinib, acts as an ALK inhibitor, and shows an IC 50 of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells. JH-VIII-157-02 also potently inhibits EML4-ALK wt (Eawt), EAC1156Y, EAF1174L, EAS1206Y (IC 50 , 2 nM), EAG1269A (IC 50 , 3 nM), EAL1196M (IC 50 , 58 nM), EA1151Tins (IC 50 , 107 nM), and EAL1152R (IC 50 , 196 nM). Moreover, JH-VIII-157-02 has selectivity at other kinases, including IRAK1, CLK4, RET, RET V804L, RET V804M and IRAK 4, and the IC 50 s are 14 nM, 14 nM, 3 nM, 13 nM, 12 nM, and 465 nM respectively. JH-VIII-157-02 exhibits inhibitory growth of cancer cell lines, such as H3122, DFCI76 (L1152R] with EC 50 s of 5, 19 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo JH-VIII-157-02 exhibits good oral bioavailability following an oral dose of 10 mg/kg in mice. JH-VIII-157-02 also penetrates the CNS of mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 2 nM (EML4-ALK G1202R, cell assay), 2 nM (EML4-ALK wt , cell assay), 2 nM (EML4-ALK C1156Y, cell assay), 2 nM (EML4-ALK F1174L, cell assay), 2 nM (EML4-ALK F1174L, cell assay) |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | CCC1=CC2=C(C=C1C3=CN(N=C3)CC(=O)N(C)C)C(C4=C(C2=O)C5=C(N4)C=C(C=C5)C#N)(C)C |
| 分子量 | 465.55 |
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