| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| G654579-1ml |
1ml |
期货  |
|
| 规格或纯度 | Moligand™, 10mM in DMSO |
|---|---|
| 英文名称 | GW 766994 |
| 生化机理 | GW 766994（GW 994）是一种口服活性特异性趋化因子受体-3（CCR3）拮抗剂。GW 766994 有潜力用于哮喘和嗜酸性粒细胞性支气管炎的研究。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 拮抗剂 |
| 作用机制 | CCR3 拮抗剂 |
| 产品介绍 |
GW 766994 (GW 994) 是特异性的趋化因子受体-3 (chemokine receptor-3) 拮抗剂。GW 766994 有潜力用于哮喘和嗜酸性支气管炎的研究。 GW 766994 (GW 994) is an orally active and specific chemokine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research In Vitro GW 766994 is a specific chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis. GW 766994 (10 μM) reverses CCL11-induced activation of CDK5, phosphorylations of CDK5, GSK3β, and increased phosphorylation of tau in hippocampal neurons. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:CCR3 7.86 (pKi) |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | C1COC(CN1CC2=CC(=C(C=C2)Cl)Cl)CNC(=O)NCC3=CC=C(C=C3)C(=O)N |
| 分子量 | 451.35 |
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