标签:JAK

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  1. JAK/STAT 抑制剂 Janus 激酶(JAK)和信号转导及转录激活因子(STAT)蛋白共同组成了一条重要的信号级联通路,该通路将细胞外信号跨越质膜传递至细胞核,从而调控基因转录。该信号通路在细胞增殖、分化、生存及宿主防御等关键生物学过程中发挥调控作用。虽然在多种细胞类型中均有广泛分布,但 JAK/STAT ...
  2. JAK/STAT Inhibitors The Janus kinase (JAK) and signal transducer and activator of transcription (STAT) proteins form a critical signaling cascade that conveys extracellular signals across the plasma membrane and into the nucleus, where they modulate gene transcription. This pathway regulates key biological ...
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