| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| F409005-1ml |
1ml |
现货  |
|
| 英文别名 | CCI-187881 | (6α,11β,16α,17α)-androsta-1,4-diene-17-carbothioic acid-6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-S-(fluoromethyl) ester |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Fluticasone propionate |
| 生化机理 | 丙酸氟替卡松（CCI-187881）是一种合成糖皮质激素，用于治疗非过敏性和过敏性鼻炎。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 作用机制 | 糖皮质激素受体激动剂 |
| 产品介绍 |
Fluticasone propionate 是一种合成的皮质类固醇，是Fluticasone的衍生物，用于治疗哮喘和过敏性鼻炎（花粉症）。A high-affinity, selective glucocorticoid receptor agonist. Information Fluticasone propionate Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid , used to treat non-allergic and allergic rhinitis. Fluticasone propionate (1 pM) inhibits the constitutive and TGF-beta-induced expression of alpha-SMA in human lung myofibroblasts. Fluticasone propionate blocks the TNF-alpha-induced nuclear translocation of the pro-inflammatory transcription factor NF-kappaB in human lung myofibroblasts. Fluticasone propionate inhibits in lung myofibroblasts, at a very early stage of differentiation, the activation of Janus kinase/STAT pathways induced by IL-13 (tyrosine kinase 2, STAT1, STAT3, STAT6, mitogen-activated protein kinase). Fluticasone propionate still displays a potential anti-inflammatory activity even if it only inhibits tyrosine kinase 2 phosphorylation in mildly or fully differentiated myofibroblastic cultures. Fluticasone propionate inhibits constitutive and TGF-beta-induced expression of alpha-smooth muscle actin, the main marker of myofibroblastic differentiation, both in very early and in mild differentiated myofibroblasts. Fluticasone propionate displays an additional powerful anti-inflammatory effect, decreasing nuclear translocation of NF-kappaB independent of the degree of myofibroblastic differentiation. Fluticasone propionate inhibits allergen-induced T-cell proliferation, expression of IL-3, IL-5 and GM-CSF mRNA, and secretion of the corresponding proteins in a concentration-dependent fashion. Fluticasone propionate has the potential markedly to inhibit allergen-induced T-cell production of asthma-relevant cytokines. In vivo Fluticasone propionate administrated after induction of a severe heaves exacerbation results in complete resolution of clinical signs, normalization of pulmonary function tests, and significant decrease in bronchoalveolar lavage (BAL) neutrophilia in horse. cell lines： Concentrations： Incubation Time： Powder Purity:≥97% |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | CCC(=O)OC1(C(C)CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC12C)C(=O)SCF |
| 分子量 | 500.57 |
| Concentration(Compounding value) | |
|---|---|
| Record the entire process by video | conform |
| 1. Guozheng Zhao. (2023) Multi-Residue Detection of Eight Glucocorticoids by Nano-Au/Fluticasone Propionate Electrochemical Immunosensor. MOLECULES, 28 (18): (6619). [PMID:37764395] [10.3390/molecules28186619] |
| 2. Youfang Huang, Yanyun Li, Qing Luo, Xiaojia Huang. (2021) One-step preparation of functional groups-rich graphene oxide and carbon nanotubes nanocomposite for efficient magnetic solid phase extraction of glucocorticoids in environmental waters. CHEMICAL ENGINEERING JOURNAL, 406 (126785). [10.1016/j.cej.2020.126785] |
| 1. Guozheng Zhao. (2023) Multi-Residue Detection of Eight Glucocorticoids by Nano-Au/Fluticasone Propionate Electrochemical Immunosensor. MOLECULES, 28 (18): (6619). [PMID:37764395] [10.3390/molecules28186619] |
| 2. Youfang Huang, Yanyun Li, Qing Luo, Xiaojia Huang. (2021) One-step preparation of functional groups-rich graphene oxide and carbon nanotubes nanocomposite for efficient magnetic solid phase extraction of glucocorticoids in environmental waters. CHEMICAL ENGINEERING JOURNAL, 406 (126785). [10.1016/j.cej.2020.126785] |
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