计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| D421816-1ml |
1ml |
现货 ![]() |
|
| 别名 | 双氯芬酸 | 奥尔芬 |
|---|---|
| 英文别名 | diclofenac | Diclofenac acid | 15307-86-5 | dichlofenac | Diclofenacum | Diclophenac | Diclofenaco | ProSorb-D | 2-(2-((2,6-Dichlorophenyl)amino)phenyl)acetic acid | Diclofenac resinate | Voltarol | Diclofenac free acid | 2-(2,6-Dichloroanilino)phenylacetic Acid | Zorovolex | Zorvol |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Diclofenac |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 环氧化酶抑制剂 |
| 产品介绍 |
Diclofenac (双氯芬酸) 是COX抑制剂,对绵羊的COX-1和-2的IC50分别为60和220 nM。 Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. Target: COX Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. The primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin. Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. Target: COX Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. The primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin. Diclofenac acid is a nonsteroidal anti-inflammatory compound and decycloxygenase (COX) inhibitor. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 2-[2-(2,6-dichloroanilino)phenyl]acetic acid |
| INCHI | InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19) |
| InChi Key | DCOPUUMXTXDBNB-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl |
| Isomeric SMILES | C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl |
| RTECS | AG6310000 |
| 分子量 | 296.15 |
| Reaxy-Rn | 2146636 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2146636&ln= |
| 熔点 | 158°C |
|---|---|
| 分子量 | 296.100 g/mol |
| XLogP3 | 4.400 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 4 |
| 精确质量Exact Mass | 295.017 Da |
| 单同位素质量Monoisotopic Mass | 295.017 Da |
| 拓扑极表面积Topological Polar Surface Area | 49.300 Ų |
| 重原子数Heavy Atom Count | 19 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 304.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS06, GHS08, GHS09 |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H301: 吞咽会中毒 H411: 对水生生物有毒并具有长期持续影响 H372: 通过长时间或反复暴露对器官造成损害 H361: 怀疑破坏生育力或未出生的孩子 |
| 预防措施声明 |
P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P201: 使用前获取特殊说明 P308+P313: 如接触到或有疑虑:求医/就诊。 P270: 使用本产品时,请勿进食、饮水或吸烟。 P391: 收集溢出物 P202: 在阅读并理解所有安全预防措施之前,不要进行操作。 P301+P310+P330: 如果吞咽:漱口。立即致电中毒中心/医生。 |
| RTECS | AG6310000 |
| Reaxy-Rn | 2146636 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2146636&ln= |
| Merck Index | 3081 |
| Record the entire process by video | conform |
|---|---|
| Concentration(Compounding value) |
| 1. Yiqing Liu, Ting Wang, Zhengjie Chen, Shenglan Liu, Yongsheng Fu. (2024) Enhanced removal of sulfamethoxazole by Mn(II)/bisulfite in presence of nitrilotriacetic acid: Role of Mn(III). Journal of Environmental Chemical Engineering, 12 (111821). [10.1016/j.jece.2023.111821] |
| 2. Lianxu Wang, Zhen Lei, Sining Yun, Xiaohuan Yang, Rong Chen. (2024) Quantitative structure-biotransformation relationships of organic micropollutants in aerobic and anaerobic wastewater treatments. SCIENCE OF THE TOTAL ENVIRONMENT, 912 (169170). [PMID:38072270] [10.1016/j.scitotenv.2023.169170] |
| 3. Jiaxin Xu, Jing Zou, Jianying Wu, Huiping Zeng, Yixin Huang, Jingxin Yang, Chunming Gong, Siying Chen, Jun Ma. (2024) Enhanced chlorination of diclofenac using ABTS as electron shuttle: Performance, mechanism and applicability. SCIENCE OF THE TOTAL ENVIRONMENT, 907 (168117). [PMID:37890637] [10.1016/j.scitotenv.2023.168117] |
| 4. Huan Zhan, Xiaoyan Liu, Jinbing Huang, Xian Liu, Xulong Zhang, Jiaxiong Yao, Shiwei Xie. (2023) Iron electrocoagulation activated peracetic acid for efficient degradation of sulfamethoxazole. CHEMICAL ENGINEERING RESEARCH & DESIGN, 200 (244). [10.1016/j.cherd.2023.10.042] |
| 5. Gilbert Audira, Jong-Chin Huang, Kelvin H.-C. Chen, Kevin Adi Kurnia, Ross D. Vasquez, Marri Jmelou M. Roldan, Yu-Heng Lai, Chung-Der Hsiao, Cheng-Yo Yen. (2023) A comprehensive painkillers screening by assessing zebrafish behaviors after caudal fin amputation. BIOMEDICINE & PHARMACOTHERAPY, 168 (115641). [PMID:37806085] [10.1016/j.biopha.2023.115641] |
| 6. Siqi Liang, Kangkang Wang, Kefu Wang, Tao Wang, Changyan Guo, Wei Wang, Jide Wang. (2023) Adsorption Behavior of Diclofenac on Polystyrene and Poly(butylene adipate-co-terephthalate) Microplastics: Influencing Factors and Adsorption Mechanism. LANGMUIR, 39 (34): (12216–12225). [PMID:37581507] [10.1021/acs.langmuir.3c01536] |
| 7. Lan-Ying Liu, Guo-Shuai Liu, Shi-Ming Niu, He Liu, Min-Hua Cui, Ai-Jie Wang. (2023) Atomic hydrogen-mediated enhanced electrocatalytic hydrodehalogenation on Pd@MXene electrodes. JOURNAL OF HAZARDOUS MATERIALS, 459 (132113). [PMID:37487329] [10.1016/j.jhazmat.2023.132113] |
| 8. Yixin Huang, Jing Zou, Jiawen Li, Hongfang Ma, Siying Chen, Lingying Chen, Xiaobin Liao, Jun Ma. (2023) Rapid spectrophotometric determination of peroxydisulfate in water via oxidative coloration of 2,2′azino-bis(3-ethylbenzothiazoline)-6-sulfonate (ABTS) using ferrous ion as catalyst. Journal of Environmental Chemical Engineering, 11 (110552). [10.1016/j.jece.2023.110552] |
| 9. Kaiyuan Luo, Yang Shi, Rongfu Huang, Xipeng Wei, Zelin Wu, Peng Zhou, Heng Zhang, Yin Wang, Zhaokun Xiong, Bo Lai. (2023) Activation of periodate by N-doped iron-based porous carbon for degradation of sulfisoxazole: Significance of catalyst-mediated electron transfer mechanism. JOURNAL OF HAZARDOUS MATERIALS, 457 (131790). [PMID:37295335] [10.1016/j.jhazmat.2023.131790] |
| 10. Xiangju Li, Xue Xue, Jia Jia, Xiaocui Zou, Yongjing Guan, Long Zhu, Zaizhao Wang. (2023) Nonsteroidal anti-inflammatory drug diclofenac accelerates the emergence of antibiotic resistance via mutagenesis. ENVIRONMENTAL POLLUTION, 326 (121457). [PMID:36958653] [10.1016/j.envpol.2023.121457] |
| 11. Pengzhao Han, Kai Hu, Yuanpeng Wang, Lixin Li, Pan Wang, Weixia Zhu, Haiyan Gong, Zhenqiang Zhang, Shusheng Zhang. (2023) Dispersive solid-phase extraction of non-steroidal anti-inflammatory drugs in water and urine samples using a magnetic ionic liquid hypercrosslinked polymer composite. JOURNAL OF CHROMATOGRAPHY A, 1689 (463745). [PMID:36586287] [10.1016/j.chroma.2022.463745] |
| 12. Chaozhi Kuang, Guoshen Zeng, Yangjian Zhou, Yaoyao Wu, Dexuan Li, Yingfei Wang, Chuanhao Li. (2023) Integrating anodic sulfate activation with cathodic H2O2 production/activation to generate the sulfate and hydroxyl radicals for the degradation of emerging organic contaminants. WATER RESEARCH, 229 (119464). [PMID:36509034] [10.1016/j.watres.2022.119464] |
| 13. Chunyan Hu, Jianyi Li, Juncheng Ke, Jianjun Liang, Qiuliang Liu, Qiliang Wang, Wentao Huang. (2023) The preparation and removal performance of carbamazepine/oxcarbazepine double template magnetic molecularly imprinted polymers. SEPARATION AND PURIFICATION TECHNOLOGY, 306 (122556). [10.1016/j.seppur.2022.122556] |
| 14. Xin Liu, Peng Xu, Shiqi Xie, Lei Wang, Zhuoyu Yang, Pengfei Zhu, Jingwei Ma, Qiulai He, John C. Crittenden. (2023) Multiple reinforcement of chloride ion on oxidizing acetaminophen with zero-valent copper particles: In-site formation and catalysis of hydrogen peroxide. CHEMICAL ENGINEERING JOURNAL, 451 (138689). [10.1016/j.cej.2022.138689] |
| 15. Lizhen Qiao, Yuan Tao, Wang Yao, Jieyu Zhao, Yang Yan. (2022) A magnetic ionic liquid based vortex-assisted dispersive liquid-liquid microextraction coupled with back-extraction for the enrichment of fluoroquinolone antibiotics. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 219 (114903). [PMID:35759827] [10.1016/j.jpba.2022.114903] |
| 16. Sixing Dai, Lei Xiao, Qinliu Li, Gazi Hao, Yubing Hu, Wei Jiang. (2022) 0D/1D Co3O4 quantum dots/surface hydroxylated g-C3N4 nanofibers heterojunction with enhanced photocatalytic removal of pharmaceuticals and personal care products. SEPARATION AND PURIFICATION TECHNOLOGY, 297 (121481). [10.1016/j.seppur.2022.121481] |
| 17. Sixing Dai, Yue Wang, Lei Xiao, Gazi Hao, Yubing Hu, Guangpu Zhang, Wei Jiang. (2022) 2D/2D/2D CuO-MXene-OCN heterojunction with enhanced photocatalytic removal of pharmaceuticals and personal care products: Characterization, efficiency and mechanism. JOURNAL OF ALLOYS AND COMPOUNDS, 919 (165873). [10.1016/j.jallcom.2022.165873] |
| 18. Xin Liu, Peng Xu, Zhuoyu Yang, Pengfei Zhu, Lei Wang, Shiqi Xie. (2022) Catalytic oxidation of 4-acetamidophenol with Fe3+-enhanced Cu0 particles: In-site generation and activation of hydrogen peroxide. JOURNAL OF HAZARDOUS MATERIALS, 436 (129291). [PMID:35739796] [10.1016/j.jhazmat.2022.129291] |
| 19. Peng Xu, Shiqi Xie, Xin Liu, Lei Wang, Xiangwen Jia, Chao Yang. (2022) Electrochemical enhanced heterogenous activation of peroxymonosulfate using CuFe2O4 particle electrodes for the degradation of diclofenac. CHEMICAL ENGINEERING JOURNAL, 446 (136941). [10.1016/j.cej.2022.136941] |
| 20. Nkoom Matthew, Lu Guanghua, Liu Jianchao. (2022) Chronic toxicity of diclofenac, carbamazepine and their mixture to Daphnia magna: a comparative two-generational study. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 29 (39): (58963-58979). [PMID:35378650] [10.1007/s11356-022-19463-w] |
| 21. Ruifeng Liang, Wenjing Ge, Bingjie Li, Weifeng Cui, Xiaofan Ma, Yuying Pan, Gengsheng Li. (2022) Evodiamine decreased the systemic exposure of pravastatin in non-alcoholic steatohepatitis rats due to the up-regulation of hepatic OATPs. PHARMACEUTICAL BIOLOGY, 60 (1): (359-373). [PMID:35171063] [10.1080/13880209.2022.2036767] |
| 22. Shuaibing Liu, Ziteng Wang, Eric Chan, Yibo Zhao, Jian Kang, Xiaojian Zhang, Xin Tian. (2022) Inhibition of cytochrome P450 enzymes and uridine 5′-diphospho-glucuronosyltransferases by vicagrel in human liver microsomes: A prediction of potential drug-drug interactions. CHEMICO-BIOLOGICAL INTERACTIONS, 352 (109775). [PMID:34910929] [10.1016/j.cbi.2021.109775] |
| 23. Yang Zhou, Fan Tong, Weilong Gu, Siqin He, Xiaotong Yang, Jiamei Li, Yue-Dong Gao, Huile Gao. (2022) Co-delivery of photosensitizer and diclofenac through sequentially responsive bilirubin nanocarriers for combating hypoxic tumors. Acta Pharmaceutica Sinica B, 12 (1416). [PMID:35530138] [10.1016/j.apsb.2021.12.001] |
| 24. Cong Pan, Libin Fu, Fenna Lide, Yaobin Ding, Chengjun Wang, Jia Huang, Shaobin Wang. (2022) Insights into bromate reduction by Fe(II): Multiple radicals generation and carbamazepine oxidation. CHEMICAL ENGINEERING JOURNAL, 431 (133957). [10.1016/j.cej.2021.133957] |
| 25. Jinbin Lin, Jing Zou, Hengyu Cai, Yixin Huang, Jiawen Li, Junyang Xiao, Baoling Yuan, Jun Ma. (2021) Hydroxylamine enhanced Fe(II)-activated peracetic acid process for diclofenac degradation: Efficiency, mechanism and effects of various parameters. WATER RESEARCH, 207 (117796). [PMID:34736001] [10.1016/j.watres.2021.117796] |
| 26. Hengyu Cai, Jing Zou, Jinbin Lin, Jiawen Li, Yixin Huang, Shuyin Zhang, Baoling Yuan, Jun Ma. (2022) Sodium hydroxide-enhanced acetaminophen elimination in heat/peroxymonosulfate system: Production of singlet oxygen and hydroxyl radical. CHEMICAL ENGINEERING JOURNAL, 429 (132438). [10.1016/j.cej.2021.132438] |
| 27. Xin Liu, Peng Xu, Qi Fu, Runhan Li, Chenxi He, Wenxuan Yao, Lei Wang, Shiqi Xie, Zhiyi Xie, Jingwei Ma, Qiulai He, John C. Crittenden. (2021) Strong degradation of orange II by activation of peroxymonosulfate using combination of ferrous ion and zero-valent copper. SEPARATION AND PURIFICATION TECHNOLOGY, 278 (119509). [10.1016/j.seppur.2021.119509] |
| 28. Sihan Li, Yanqi Gan, Syed Jalil Shah, Ruimeng Wang, Wenxue Gong, Rule Wei, Hongbing Ji, Zhongxing Zhao, Zhenxia Zhao. (2021) Engineering NSAIDs imprinted UiO-66s for markedly enhanced adsorption of coexisting diclofenac sodium and Cu(II) and their synergistic adsorption mechanism. CHEMICAL ENGINEERING JOURNAL, 426 (131440). [10.1016/j.cej.2021.131440] |
| 29. Lizhen Qiao, Ruiting Sun, Chunmei Yu, Yuan Tao, Yang Yan. (2021) Novel hydrophobic deep eutectic solvents for ultrasound-assisted dispersive liquid-liquid microextraction of trace non-steroidal anti-inflammatory drugs in water and milk samples. MICROCHEMICAL JOURNAL, 170 (106686). [10.1016/j.microc.2021.106686] |
| 30. Yixin Huang, Jinbin Lin, Jing Zou, Jiaxin Xu, Mengyun Wang, Huahua Cai, Baoling Yuan, Jun Ma. (2021) ABTS as an electron shuttle to accelerate the degradation of diclofenac with horseradish peroxidase-catalyzed hydrogen peroxide oxidation. SCIENCE OF THE TOTAL ENVIRONMENT, 798 (149276). [PMID:34333427] [10.1016/j.scitotenv.2021.149276] |
| 31. Li Jingxian, Shan Xueling, Jiang Ding, Wang Wenchang, Xu Fangmin, Chen Zhidong. (2021) Au nanoparticle plasmon-enhanced electrochemiluminescence aptasensor based on the 1D/2D PTCA/CoP for diclofenac assay. MICROCHIMICA ACTA, 188 (7): (1-10). [PMID:34132907] [10.1007/s00604-021-04879-x] |
| 32. Jinbin Lin, Yuye Hu, Junyang Xiao, Yixin Huang, Mengyun Wang, Haoyu Yang, Jing Zou, Baoling Yuan, Jun Ma. (2021) Enhanced diclofenac elimination in Fe(II)/peracetic acid process by promoting Fe(III)/Fe(II) cycle with ABTS as electron shuttle. CHEMICAL ENGINEERING JOURNAL, 420 (129692). [10.1016/j.cej.2021.129692] |
| 33. Yunlan Peng, Hongle Shi, Zhenran Wang, Yongsheng Fu, Yiqing Liu. (2021) Kinetics and reaction mechanism of photochemical degradation of diclofenac by UV-activated peroxymonosulfate. RSC Advances, 11 (12): (6804-6817). [PMID:35423182] [10.1039/D0RA10178H] |
| 34. Matthew Nkoom, Guanghua Lu, Jianchao Liu, Huike Dong. (2020) Biological uptake, depuration and biochemical effects of diclofenac and carbamazepine in Carassius carassius. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 205 (111106). [PMID:32818877] [10.1016/j.ecoenv.2020.111106] |
| 35. Yang Guo, Erzhuo Zhao, Jun Wang, Xiaoyuan Zhang, Haiou Huang, Gang Yu, Yujue Wang. (2020) Comparison of emerging contaminant abatement by conventional ozonation, catalytic ozonation, O3/H2O2 and electro-peroxone processes. JOURNAL OF HAZARDOUS MATERIALS, 389 (121829). [PMID:31836369] [10.1016/j.jhazmat.2019.121829] |
| 36. Xin Liu, Baoling Yuan, Jing Zou, Lingbin Wu, Lin Dai, Hongfang Ma, Kai Li, Jun Ma. (2020) Cu(II)-enhanced degradation of acid orange 7 by Fe(II)-activated persulfate with hydroxylamine over a wide pH range. CHEMOSPHERE, 238 (124533). [PMID:31466004] [10.1016/j.chemosphere.2019.124533] |
| 37. Nadeem Muhammad, Dandan Guo, Yun Zhang, Azeem Intisar, Qamar Subhani, Muhammad Abdul Qadir, Hairong Cui. (2019) Online clean-up setup for the determination of non-fluorescent acidic pharmaceutical drugs in complex biological samples. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1126-1127 (121708). [PMID:31437773] [10.1016/j.jchromb.2019.06.035] |
| 38. Nkoom Matthew, Lu Guanghua, Liu Jianchao, Dong Huike, Yang Haohan. (2019) Bioconcentration, behavioral, and biochemical effects of the non-steroidal anti-inflammatory drug diclofenac in Daphnia magna. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 26 (6): (5704-5712). [PMID:30612359] [10.1007/s11356-018-04072-3] |
| 39. Zhuang-Song Huang, Lu Wang, Yu-Lei Liu, Jin Jiang, Mang Xue, Cheng-Biao Xu, Yu-Fei Zhen, Yi-Cheng Wang, Jun Ma. (2018) Impact of Phosphate on Ferrate Oxidation of Organic Compounds: An Underestimated Oxidant. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 52 (23): (13897–13907). [PMID:30379540] [10.1021/acs.est.8b04655] |
| 40. Na Li, Juan Chen, Yan-Ping Shi. (2019) Magnetic polyethyleneimine functionalized reduced graphene oxide as a novel magnetic sorbent for the separation of polar non-steroidal anti-inflammatory drugs in waters. TALANTA, 191 (526). [PMID:30262094] [10.1016/j.talanta.2018.09.006] |
| 41. Luo Zhi-yuan, Li Zhi-yong, Liu Hai-yan, Tang Min-qiong, Shi Zhi-guo. (2015) Click chemistry-based synthesis of water-dispersible hydrophobic magnetic nanoparticles for use in solid phase extraction of non-steroidal anti-inflammatory drugs. MICROCHIMICA ACTA, 182 (15): (2585-2591). [10.1007/s00604-015-1638-x] |
| 42. Zhen Chen,Shaoxiong He,Mingshan Zhu,Chaohai Wei. (2019-12-26) The effect of peroxymonosulfate in WS2 nanosheets for the removal of diclofenac: Information exposure and degradation pathway.. Chemosphere, 245 (125678-125678). [PMID:31875574] |
| 43. Wang, et al.. (2021) Inhibition of human UDP-glucuronosyltransferase enzyme by belinostat: Implications for drug-drug interactions.. Toxicology Letters, 338 (51-57). [PMID:33290829] |
| 1. Yiqing Liu, Ting Wang, Zhengjie Chen, Shenglan Liu, Yongsheng Fu. (2024) Enhanced removal of sulfamethoxazole by Mn(II)/bisulfite in presence of nitrilotriacetic acid: Role of Mn(III). Journal of Environmental Chemical Engineering, 12 (111821). [10.1016/j.jece.2023.111821] |
| 2. Lianxu Wang, Zhen Lei, Sining Yun, Xiaohuan Yang, Rong Chen. (2024) Quantitative structure-biotransformation relationships of organic micropollutants in aerobic and anaerobic wastewater treatments. SCIENCE OF THE TOTAL ENVIRONMENT, 912 (169170). [PMID:38072270] [10.1016/j.scitotenv.2023.169170] |
| 3. Jiaxin Xu, Jing Zou, Jianying Wu, Huiping Zeng, Yixin Huang, Jingxin Yang, Chunming Gong, Siying Chen, Jun Ma. (2024) Enhanced chlorination of diclofenac using ABTS as electron shuttle: Performance, mechanism and applicability. SCIENCE OF THE TOTAL ENVIRONMENT, 907 (168117). [PMID:37890637] [10.1016/j.scitotenv.2023.168117] |
| 4. Huan Zhan, Xiaoyan Liu, Jinbing Huang, Xian Liu, Xulong Zhang, Jiaxiong Yao, Shiwei Xie. (2023) Iron electrocoagulation activated peracetic acid for efficient degradation of sulfamethoxazole. CHEMICAL ENGINEERING RESEARCH & DESIGN, 200 (244). [10.1016/j.cherd.2023.10.042] |
| 5. Gilbert Audira, Jong-Chin Huang, Kelvin H.-C. Chen, Kevin Adi Kurnia, Ross D. Vasquez, Marri Jmelou M. Roldan, Yu-Heng Lai, Chung-Der Hsiao, Cheng-Yo Yen. (2023) A comprehensive painkillers screening by assessing zebrafish behaviors after caudal fin amputation. BIOMEDICINE & PHARMACOTHERAPY, 168 (115641). [PMID:37806085] [10.1016/j.biopha.2023.115641] |
| 6. Siqi Liang, Kangkang Wang, Kefu Wang, Tao Wang, Changyan Guo, Wei Wang, Jide Wang. (2023) Adsorption Behavior of Diclofenac on Polystyrene and Poly(butylene adipate-co-terephthalate) Microplastics: Influencing Factors and Adsorption Mechanism. LANGMUIR, 39 (34): (12216–12225). [PMID:37581507] [10.1021/acs.langmuir.3c01536] |
| 7. Lan-Ying Liu, Guo-Shuai Liu, Shi-Ming Niu, He Liu, Min-Hua Cui, Ai-Jie Wang. (2023) Atomic hydrogen-mediated enhanced electrocatalytic hydrodehalogenation on Pd@MXene electrodes. JOURNAL OF HAZARDOUS MATERIALS, 459 (132113). [PMID:37487329] [10.1016/j.jhazmat.2023.132113] |
| 8. Yixin Huang, Jing Zou, Jiawen Li, Hongfang Ma, Siying Chen, Lingying Chen, Xiaobin Liao, Jun Ma. (2023) Rapid spectrophotometric determination of peroxydisulfate in water via oxidative coloration of 2,2′azino-bis(3-ethylbenzothiazoline)-6-sulfonate (ABTS) using ferrous ion as catalyst. Journal of Environmental Chemical Engineering, 11 (110552). [10.1016/j.jece.2023.110552] |
| 9. Kaiyuan Luo, Yang Shi, Rongfu Huang, Xipeng Wei, Zelin Wu, Peng Zhou, Heng Zhang, Yin Wang, Zhaokun Xiong, Bo Lai. (2023) Activation of periodate by N-doped iron-based porous carbon for degradation of sulfisoxazole: Significance of catalyst-mediated electron transfer mechanism. JOURNAL OF HAZARDOUS MATERIALS, 457 (131790). [PMID:37295335] [10.1016/j.jhazmat.2023.131790] |
| 10. Xiangju Li, Xue Xue, Jia Jia, Xiaocui Zou, Yongjing Guan, Long Zhu, Zaizhao Wang. (2023) Nonsteroidal anti-inflammatory drug diclofenac accelerates the emergence of antibiotic resistance via mutagenesis. ENVIRONMENTAL POLLUTION, 326 (121457). [PMID:36958653] [10.1016/j.envpol.2023.121457] |
| 11. Pengzhao Han, Kai Hu, Yuanpeng Wang, Lixin Li, Pan Wang, Weixia Zhu, Haiyan Gong, Zhenqiang Zhang, Shusheng Zhang. (2023) Dispersive solid-phase extraction of non-steroidal anti-inflammatory drugs in water and urine samples using a magnetic ionic liquid hypercrosslinked polymer composite. JOURNAL OF CHROMATOGRAPHY A, 1689 (463745). [PMID:36586287] [10.1016/j.chroma.2022.463745] |
| 12. Chaozhi Kuang, Guoshen Zeng, Yangjian Zhou, Yaoyao Wu, Dexuan Li, Yingfei Wang, Chuanhao Li. (2023) Integrating anodic sulfate activation with cathodic H2O2 production/activation to generate the sulfate and hydroxyl radicals for the degradation of emerging organic contaminants. WATER RESEARCH, 229 (119464). [PMID:36509034] [10.1016/j.watres.2022.119464] |
| 13. Chunyan Hu, Jianyi Li, Juncheng Ke, Jianjun Liang, Qiuliang Liu, Qiliang Wang, Wentao Huang. (2023) The preparation and removal performance of carbamazepine/oxcarbazepine double template magnetic molecularly imprinted polymers. SEPARATION AND PURIFICATION TECHNOLOGY, 306 (122556). [10.1016/j.seppur.2022.122556] |
| 14. Xin Liu, Peng Xu, Shiqi Xie, Lei Wang, Zhuoyu Yang, Pengfei Zhu, Jingwei Ma, Qiulai He, John C. Crittenden. (2023) Multiple reinforcement of chloride ion on oxidizing acetaminophen with zero-valent copper particles: In-site formation and catalysis of hydrogen peroxide. CHEMICAL ENGINEERING JOURNAL, 451 (138689). [10.1016/j.cej.2022.138689] |
| 15. Lizhen Qiao, Yuan Tao, Wang Yao, Jieyu Zhao, Yang Yan. (2022) A magnetic ionic liquid based vortex-assisted dispersive liquid-liquid microextraction coupled with back-extraction for the enrichment of fluoroquinolone antibiotics. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 219 (114903). [PMID:35759827] [10.1016/j.jpba.2022.114903] |
| 16. Sixing Dai, Lei Xiao, Qinliu Li, Gazi Hao, Yubing Hu, Wei Jiang. (2022) 0D/1D Co3O4 quantum dots/surface hydroxylated g-C3N4 nanofibers heterojunction with enhanced photocatalytic removal of pharmaceuticals and personal care products. SEPARATION AND PURIFICATION TECHNOLOGY, 297 (121481). [10.1016/j.seppur.2022.121481] |
| 17. Sixing Dai, Yue Wang, Lei Xiao, Gazi Hao, Yubing Hu, Guangpu Zhang, Wei Jiang. (2022) 2D/2D/2D CuO-MXene-OCN heterojunction with enhanced photocatalytic removal of pharmaceuticals and personal care products: Characterization, efficiency and mechanism. JOURNAL OF ALLOYS AND COMPOUNDS, 919 (165873). [10.1016/j.jallcom.2022.165873] |
| 18. Xin Liu, Peng Xu, Zhuoyu Yang, Pengfei Zhu, Lei Wang, Shiqi Xie. (2022) Catalytic oxidation of 4-acetamidophenol with Fe3+-enhanced Cu0 particles: In-site generation and activation of hydrogen peroxide. JOURNAL OF HAZARDOUS MATERIALS, 436 (129291). [PMID:35739796] [10.1016/j.jhazmat.2022.129291] |
| 19. Peng Xu, Shiqi Xie, Xin Liu, Lei Wang, Xiangwen Jia, Chao Yang. (2022) Electrochemical enhanced heterogenous activation of peroxymonosulfate using CuFe2O4 particle electrodes for the degradation of diclofenac. CHEMICAL ENGINEERING JOURNAL, 446 (136941). [10.1016/j.cej.2022.136941] |
| 20. Nkoom Matthew, Lu Guanghua, Liu Jianchao. (2022) Chronic toxicity of diclofenac, carbamazepine and their mixture to Daphnia magna: a comparative two-generational study. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 29 (39): (58963-58979). [PMID:35378650] [10.1007/s11356-022-19463-w] |
| 21. Ruifeng Liang, Wenjing Ge, Bingjie Li, Weifeng Cui, Xiaofan Ma, Yuying Pan, Gengsheng Li. (2022) Evodiamine decreased the systemic exposure of pravastatin in non-alcoholic steatohepatitis rats due to the up-regulation of hepatic OATPs. PHARMACEUTICAL BIOLOGY, 60 (1): (359-373). [PMID:35171063] [10.1080/13880209.2022.2036767] |
| 22. Shuaibing Liu, Ziteng Wang, Eric Chan, Yibo Zhao, Jian Kang, Xiaojian Zhang, Xin Tian. (2022) Inhibition of cytochrome P450 enzymes and uridine 5′-diphospho-glucuronosyltransferases by vicagrel in human liver microsomes: A prediction of potential drug-drug interactions. CHEMICO-BIOLOGICAL INTERACTIONS, 352 (109775). [PMID:34910929] [10.1016/j.cbi.2021.109775] |
| 23. Yang Zhou, Fan Tong, Weilong Gu, Siqin He, Xiaotong Yang, Jiamei Li, Yue-Dong Gao, Huile Gao. (2022) Co-delivery of photosensitizer and diclofenac through sequentially responsive bilirubin nanocarriers for combating hypoxic tumors. Acta Pharmaceutica Sinica B, 12 (1416). [PMID:35530138] [10.1016/j.apsb.2021.12.001] |
| 24. Cong Pan, Libin Fu, Fenna Lide, Yaobin Ding, Chengjun Wang, Jia Huang, Shaobin Wang. (2022) Insights into bromate reduction by Fe(II): Multiple radicals generation and carbamazepine oxidation. CHEMICAL ENGINEERING JOURNAL, 431 (133957). [10.1016/j.cej.2021.133957] |
| 25. Jinbin Lin, Jing Zou, Hengyu Cai, Yixin Huang, Jiawen Li, Junyang Xiao, Baoling Yuan, Jun Ma. (2021) Hydroxylamine enhanced Fe(II)-activated peracetic acid process for diclofenac degradation: Efficiency, mechanism and effects of various parameters. WATER RESEARCH, 207 (117796). [PMID:34736001] [10.1016/j.watres.2021.117796] |
| 26. Hengyu Cai, Jing Zou, Jinbin Lin, Jiawen Li, Yixin Huang, Shuyin Zhang, Baoling Yuan, Jun Ma. (2022) Sodium hydroxide-enhanced acetaminophen elimination in heat/peroxymonosulfate system: Production of singlet oxygen and hydroxyl radical. CHEMICAL ENGINEERING JOURNAL, 429 (132438). [10.1016/j.cej.2021.132438] |
| 27. Xin Liu, Peng Xu, Qi Fu, Runhan Li, Chenxi He, Wenxuan Yao, Lei Wang, Shiqi Xie, Zhiyi Xie, Jingwei Ma, Qiulai He, John C. Crittenden. (2021) Strong degradation of orange II by activation of peroxymonosulfate using combination of ferrous ion and zero-valent copper. SEPARATION AND PURIFICATION TECHNOLOGY, 278 (119509). [10.1016/j.seppur.2021.119509] |
| 28. Sihan Li, Yanqi Gan, Syed Jalil Shah, Ruimeng Wang, Wenxue Gong, Rule Wei, Hongbing Ji, Zhongxing Zhao, Zhenxia Zhao. (2021) Engineering NSAIDs imprinted UiO-66s for markedly enhanced adsorption of coexisting diclofenac sodium and Cu(II) and their synergistic adsorption mechanism. CHEMICAL ENGINEERING JOURNAL, 426 (131440). [10.1016/j.cej.2021.131440] |
| 29. Lizhen Qiao, Ruiting Sun, Chunmei Yu, Yuan Tao, Yang Yan. (2021) Novel hydrophobic deep eutectic solvents for ultrasound-assisted dispersive liquid-liquid microextraction of trace non-steroidal anti-inflammatory drugs in water and milk samples. MICROCHEMICAL JOURNAL, 170 (106686). [10.1016/j.microc.2021.106686] |
| 30. Yixin Huang, Jinbin Lin, Jing Zou, Jiaxin Xu, Mengyun Wang, Huahua Cai, Baoling Yuan, Jun Ma. (2021) ABTS as an electron shuttle to accelerate the degradation of diclofenac with horseradish peroxidase-catalyzed hydrogen peroxide oxidation. SCIENCE OF THE TOTAL ENVIRONMENT, 798 (149276). [PMID:34333427] [10.1016/j.scitotenv.2021.149276] |
| 31. Li Jingxian, Shan Xueling, Jiang Ding, Wang Wenchang, Xu Fangmin, Chen Zhidong. (2021) Au nanoparticle plasmon-enhanced electrochemiluminescence aptasensor based on the 1D/2D PTCA/CoP for diclofenac assay. MICROCHIMICA ACTA, 188 (7): (1-10). [PMID:34132907] [10.1007/s00604-021-04879-x] |
| 32. Jinbin Lin, Yuye Hu, Junyang Xiao, Yixin Huang, Mengyun Wang, Haoyu Yang, Jing Zou, Baoling Yuan, Jun Ma. (2021) Enhanced diclofenac elimination in Fe(II)/peracetic acid process by promoting Fe(III)/Fe(II) cycle with ABTS as electron shuttle. CHEMICAL ENGINEERING JOURNAL, 420 (129692). [10.1016/j.cej.2021.129692] |
| 33. Yunlan Peng, Hongle Shi, Zhenran Wang, Yongsheng Fu, Yiqing Liu. (2021) Kinetics and reaction mechanism of photochemical degradation of diclofenac by UV-activated peroxymonosulfate. RSC Advances, 11 (12): (6804-6817). [PMID:35423182] [10.1039/D0RA10178H] |
| 34. Matthew Nkoom, Guanghua Lu, Jianchao Liu, Huike Dong. (2020) Biological uptake, depuration and biochemical effects of diclofenac and carbamazepine in Carassius carassius. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 205 (111106). [PMID:32818877] [10.1016/j.ecoenv.2020.111106] |
| 35. Yang Guo, Erzhuo Zhao, Jun Wang, Xiaoyuan Zhang, Haiou Huang, Gang Yu, Yujue Wang. (2020) Comparison of emerging contaminant abatement by conventional ozonation, catalytic ozonation, O3/H2O2 and electro-peroxone processes. JOURNAL OF HAZARDOUS MATERIALS, 389 (121829). [PMID:31836369] [10.1016/j.jhazmat.2019.121829] |
| 36. Xin Liu, Baoling Yuan, Jing Zou, Lingbin Wu, Lin Dai, Hongfang Ma, Kai Li, Jun Ma. (2020) Cu(II)-enhanced degradation of acid orange 7 by Fe(II)-activated persulfate with hydroxylamine over a wide pH range. CHEMOSPHERE, 238 (124533). [PMID:31466004] [10.1016/j.chemosphere.2019.124533] |
| 37. Nadeem Muhammad, Dandan Guo, Yun Zhang, Azeem Intisar, Qamar Subhani, Muhammad Abdul Qadir, Hairong Cui. (2019) Online clean-up setup for the determination of non-fluorescent acidic pharmaceutical drugs in complex biological samples. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1126-1127 (121708). [PMID:31437773] [10.1016/j.jchromb.2019.06.035] |
| 38. Nkoom Matthew, Lu Guanghua, Liu Jianchao, Dong Huike, Yang Haohan. (2019) Bioconcentration, behavioral, and biochemical effects of the non-steroidal anti-inflammatory drug diclofenac in Daphnia magna. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 26 (6): (5704-5712). [PMID:30612359] [10.1007/s11356-018-04072-3] |
| 39. Zhuang-Song Huang, Lu Wang, Yu-Lei Liu, Jin Jiang, Mang Xue, Cheng-Biao Xu, Yu-Fei Zhen, Yi-Cheng Wang, Jun Ma. (2018) Impact of Phosphate on Ferrate Oxidation of Organic Compounds: An Underestimated Oxidant. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 52 (23): (13897–13907). [PMID:30379540] [10.1021/acs.est.8b04655] |
| 40. Na Li, Juan Chen, Yan-Ping Shi. (2019) Magnetic polyethyleneimine functionalized reduced graphene oxide as a novel magnetic sorbent for the separation of polar non-steroidal anti-inflammatory drugs in waters. TALANTA, 191 (526). [PMID:30262094] [10.1016/j.talanta.2018.09.006] |
| 41. Luo Zhi-yuan, Li Zhi-yong, Liu Hai-yan, Tang Min-qiong, Shi Zhi-guo. (2015) Click chemistry-based synthesis of water-dispersible hydrophobic magnetic nanoparticles for use in solid phase extraction of non-steroidal anti-inflammatory drugs. MICROCHIMICA ACTA, 182 (15): (2585-2591). [10.1007/s00604-015-1638-x] |
| 42. Zhen Chen,Shaoxiong He,Mingshan Zhu,Chaohai Wei. (2019-12-26) The effect of peroxymonosulfate in WS2 nanosheets for the removal of diclofenac: Information exposure and degradation pathway.. Chemosphere, 245 (125678-125678). [PMID:31875574] |
| 43. Wang, et al.. (2021) Inhibition of human UDP-glucuronosyltransferase enzyme by belinostat: Implications for drug-drug interactions.. Toxicology Letters, 338 (51-57). [PMID:33290829] |