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D-(-)-炔诺孕酮, 孕酮受体激动剂

合成孕酮类似物
11篇引用文献
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
D129210-50mg
 50mg 现货 Stock Image
D129210-250mg
 250mg 现货 Stock Image
D129210-1g
 1g 现货 Stock Image
D129210-5g
 5g 现货 Stock Image
大包装询价 收藏夹 比较  SDS中文版  DATASHEET
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Progesterone Receptor (45) Progesterone receptor Agonist (13) Vitamin D Related/Nuclear Receptor (908)
main product photo

基本描述

别名 (-)-炔诺孕酮 | (-)-左炔诺孕酮 | (-)-17α-乙炔基-18-甲基-19-去甲睾酮 | (-)-18,19-双失碳-13β-乙基-17β-羟基-4-孕甾烯-20-炔-3-酮
英文别名 Levonorgestrelum | (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one | 13-Ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one | alpha-Norgestrel | FH-122A | Monovar | NORGE
规格或纯度 Moligand™, ≥99%
英文名称 D(-)-Norgestrel
生化机理 合成孕酮类似物；与孕激素受体结合（雌激素受体，糖皮质激素受体，盐皮质激素受体，雄激素受体和孕激素受体的相对结合亲和力分别<0.02、7.5、17、58和323％）。
储存温度 -20°C储存
运输条件 超低温冰袋运输
作用类型 激动剂
作用机制 孕酮受体激动剂
产品介绍

(-)-炔诺孕酮

关联靶点（人）

PGR Tclin 孕酮受体(Progesterone receptor) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
F2 Tclin Thrombin (11687 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Homo sapiens (32628 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (1191 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ABCB11 Tchem Bile salt export pump (2311 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ABCC3 Tbio Canalicular multispecific organic anion transporter 2 (718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ABCC4 Tchem Multidrug resistance-associated protein 4 (785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 212-349-8
分子类型 小分子
IUPAC Name (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
INCHI InChI=1S/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1
InChi Key WWYNJERNGUHSAO-XUDSTZEESA-N
Canonical SMILES CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Isomeric SMILES CC[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC(=O)CC[C@H]34
WGK Germany 3
RTECS JF8259000
PubChem CID 13109
分子量 312.45

化学和物理性质

溶解性 溶于DMSO, 最高浓度 (mg/mL): 31.25, 最高浓度(mM): 100
敏感性 对热敏感
比旋光度 [α]D：-34~-31° (C=1,CHCl3)
熔点 236℃
分子量 312.400 g/mol
XLogP3 3.300
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 2
可旋转键计数Rotatable Bond Count 2
精确质量Exact Mass 312.209 Da
单同位素质量Monoisotopic Mass 312.209 Da
拓扑极表面积Topological Polar Surface Area 37.300 Ų
重原子数Heavy Atom Count 23
形式电荷Formal Charge 0
复杂度Complexity 609.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 6
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS08,   GHS09
信号词 Danger
危险声明

H351: 怀疑引起遗传缺陷

H400: 对水生生物有剧毒

H410: 对水生生物有剧毒并具有长期持续影响

H360: 可能损害生育力或未出生的孩子

H362: 可能对母乳喂养的孩子造成伤害
预防措施声明

P273: 避免释放到环境中。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P391: 收集溢出物

P263: 避免在怀孕期间/哺乳期间接触。

P203: 使用前，获取、阅读并遵守所有安全说明。

P318: 如果暴露或担心，请就医。
WGK Germany 3
RTECS JF8259000
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

 SDS英文版

质量标准

Melting point 234-238（℃）
Specific Rotation [a]20/D(c=1 in CHCL3) -34--31（°）
Purity(HPLC) 98-100（%）
NMR Spectrum 1H Conforms to Structure

 质量标准

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到3个结果

批号(Lot Number) 证书类型 日期 货号
D1909143 分析证书 24-09-04 D129210
F2229355 分析证书 24-05-09 D129210
F2229346 分析证书 24-04-15 D129210

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?
1. Qiuye Jin, Qiong Duan, Dingyu Ji, Jie Chang, Zhaomin Tang.  (2023)  Reaction mechanism, degradation pathway and toxicity assessment of NH4+ enhanced potassium ferrate removal of levofloxacin.  PROCESS SAFETY AND ENVIRONMENTAL PROTECTION,  180  (725).  [10.1016/j.psep.2023.10.037]
2. Guangli Li, Xuan Wan, Yonghui Xia, Du Tuo, Xiaoman Qi, Tianyu Wang, Mohammad Mehmandoust, Nevin Erk, Quanguo He, Qing Li.  (2023)  Lamellar α-Zirconium Phosphate Nanoparticles Supported on N-Doped Graphene Nanosheets as Electrocatalysts for the Detection of Levofloxacin.  ACS Applied Nano Materials,  6  (18): (17040–17052).  [10.1021/acsanm.3c03162]
3. Tingting Li, Guoqiang Guo, Haoming Xing, Siyuan Tang, Houwen Hu, Linfan Wang, Xiaoqing Qian, Da Chen.  (2023)  Construction of fluorescent sensor array and three-dimensional microfluidic paper based analytical device for specific identification and visual determination of antibiotics in food.  FOOD CHEMISTRY,  429  (136947).  [PMID:37499515] [10.1016/j.foodchem.2023.136947]
4. Donghui Wang, Yu-e Shi, Zhen Zhang, Song Shen, Zhenguang Wang.  (2023)  Modulating Emission of Organic Emitters from Fluorescence to Red Afterglow through Boric Acid-Assisted Energy Transfer.  Journal of Physical Chemistry C,  127  (1): (682–688).  [10.1021/acs.jpcc.2c07138]
5. Anhua Jiang, Xinwen Huang, Geshan Zhang, Wanquan Yang.  (2022)  A Study of the Degradation of LEV by Transparent PVA/NCD-TiO2 Nanocomposite Films with Enhanced Visible-Light Photocatalytic Activity.  Catalysts,  12  (11): (1336).  [10.3390/catal12111336]
6. Qinyue Wu, Yan Zhang, He Liu, Hongbo Liu, Jia Tao, Min-Hua Cui, Zhiyong Zheng, Donghui Wen, Xinmin Zhan.  (2022)  FexN produced in pharmaceutical sludge biochar by endogenous Fe and exogenous N doping to enhance peroxymonosulfate activation for levofloxacin degradation.  WATER RESEARCH,  224  (119022).  [PMID:36099758] [10.1016/j.watres.2022.119022]
7. Xiang-Yu Zheng, Hai-Chen Zhang, Yu-Dan Lv, Feng-Yan Jin, Xiu-Juan Wu, Jie Zhu, Yang Ruan.  (2022)  Levetiracetam alleviates cognitive decline in Alzheimer's disease animal model by ameliorating the dysfunction of the neuronal network..  Frontiers in Aging Neuroscience,  14  (888784-888784).  [PMID:36092803] [10.3389/fnagi.2022.888784]
8. Yichen Zhang, Shugui Hua, Xiaoqin Sun, Zhuoyue Liu, Yuan Dang, Liang Zhang, Yuanzhen Zhou.  (2021)  A novel electrochemical cathode based on sea urchin-like NiO/Co3O4 composite inducing efficient Fenton-like process for levofloxacin degradation.  APPLIED CATALYSIS A-GENERAL,  628  (118403).  [10.1016/j.apcata.2021.118403]
9. Yafeng Jin, Guangri Xu, Xiaobo Li, Jingjing Ma, Li Yang, Yuanchao Li, Huan Zhang, Zhen Zhang, Donghao Yao, Donghao Li.  (2021)  Fast cathodic reduction electrodeposition of a binder-free cobalt-doped Ni-MOF film for directly sensing of levofloxacin.  JOURNAL OF ALLOYS AND COMPOUNDS,  851  (156823).  [10.1016/j.jallcom.2020.156823]
10. Huikai Shao, Haibo Zhou, Tingting Zhang, Xianglong Zhao, Zhengjin Jiang, Qiqin Wang.  (2019)  Preparation of molecularly imprinted hybrid monoliths for the selective detection of fluoroquinolones in infant formula powders.  JOURNAL OF CHROMATOGRAPHY A,  1588  (33).  [PMID:30587346] [10.1016/j.chroma.2018.12.038]
11. Liu Chaoqiao, Xie Dong, Liu Peng, Xie Shilei, Wang Shoushan, Cheng Faliang, Zhang Min, Wang Lishi.  (2019)  Voltammetric determination of levofloxacin using silver nanoparticles deposited on a thin nickel oxide porous film.  MICROCHIMICA ACTA,  186  (1): (1-10).  [PMID:30554349] [10.1007/s00604-018-3146-2]

参考文献

1. Qiuye Jin, Qiong Duan, Dingyu Ji, Jie Chang, Zhaomin Tang.  (2023)  Reaction mechanism, degradation pathway and toxicity assessment of NH4+ enhanced potassium ferrate removal of levofloxacin.  PROCESS SAFETY AND ENVIRONMENTAL PROTECTION,  180  (725).  [10.1016/j.psep.2023.10.037]
2. Guangli Li, Xuan Wan, Yonghui Xia, Du Tuo, Xiaoman Qi, Tianyu Wang, Mohammad Mehmandoust, Nevin Erk, Quanguo He, Qing Li.  (2023)  Lamellar α-Zirconium Phosphate Nanoparticles Supported on N-Doped Graphene Nanosheets as Electrocatalysts for the Detection of Levofloxacin.  ACS Applied Nano Materials,  6  (18): (17040–17052).  [10.1021/acsanm.3c03162]
3. Tingting Li, Guoqiang Guo, Haoming Xing, Siyuan Tang, Houwen Hu, Linfan Wang, Xiaoqing Qian, Da Chen.  (2023)  Construction of fluorescent sensor array and three-dimensional microfluidic paper based analytical device for specific identification and visual determination of antibiotics in food.  FOOD CHEMISTRY,  429  (136947).  [PMID:37499515] [10.1016/j.foodchem.2023.136947]
4. Donghui Wang, Yu-e Shi, Zhen Zhang, Song Shen, Zhenguang Wang.  (2023)  Modulating Emission of Organic Emitters from Fluorescence to Red Afterglow through Boric Acid-Assisted Energy Transfer.  Journal of Physical Chemistry C,  127  (1): (682–688).  [10.1021/acs.jpcc.2c07138]
5. Anhua Jiang, Xinwen Huang, Geshan Zhang, Wanquan Yang.  (2022)  A Study of the Degradation of LEV by Transparent PVA/NCD-TiO2 Nanocomposite Films with Enhanced Visible-Light Photocatalytic Activity.  Catalysts,  12  (11): (1336).  [10.3390/catal12111336]
6. Qinyue Wu, Yan Zhang, He Liu, Hongbo Liu, Jia Tao, Min-Hua Cui, Zhiyong Zheng, Donghui Wen, Xinmin Zhan.  (2022)  FexN produced in pharmaceutical sludge biochar by endogenous Fe and exogenous N doping to enhance peroxymonosulfate activation for levofloxacin degradation.  WATER RESEARCH,  224  (119022).  [PMID:36099758] [10.1016/j.watres.2022.119022]
7. Xiang-Yu Zheng, Hai-Chen Zhang, Yu-Dan Lv, Feng-Yan Jin, Xiu-Juan Wu, Jie Zhu, Yang Ruan.  (2022)  Levetiracetam alleviates cognitive decline in Alzheimer's disease animal model by ameliorating the dysfunction of the neuronal network..  Frontiers in Aging Neuroscience,  14  (888784-888784).  [PMID:36092803] [10.3389/fnagi.2022.888784]
8. Yichen Zhang, Shugui Hua, Xiaoqin Sun, Zhuoyue Liu, Yuan Dang, Liang Zhang, Yuanzhen Zhou.  (2021)  A novel electrochemical cathode based on sea urchin-like NiO/Co3O4 composite inducing efficient Fenton-like process for levofloxacin degradation.  APPLIED CATALYSIS A-GENERAL,  628  (118403).  [10.1016/j.apcata.2021.118403]
9. Yafeng Jin, Guangri Xu, Xiaobo Li, Jingjing Ma, Li Yang, Yuanchao Li, Huan Zhang, Zhen Zhang, Donghao Yao, Donghao Li.  (2021)  Fast cathodic reduction electrodeposition of a binder-free cobalt-doped Ni-MOF film for directly sensing of levofloxacin.  JOURNAL OF ALLOYS AND COMPOUNDS,  851  (156823).  [10.1016/j.jallcom.2020.156823]
10. Huikai Shao, Haibo Zhou, Tingting Zhang, Xianglong Zhao, Zhengjin Jiang, Qiqin Wang.  (2019)  Preparation of molecularly imprinted hybrid monoliths for the selective detection of fluoroquinolones in infant formula powders.  JOURNAL OF CHROMATOGRAPHY A,  1588  (33).  [PMID:30587346] [10.1016/j.chroma.2018.12.038]
11. Liu Chaoqiao, Xie Dong, Liu Peng, Xie Shilei, Wang Shoushan, Cheng Faliang, Zhang Min, Wang Lishi.  (2019)  Voltammetric determination of levofloxacin using silver nanoparticles deposited on a thin nickel oxide porous film.  MICROCHIMICA ACTA,  186  (1): (1-10).  [PMID:30554349] [10.1007/s00604-018-3146-2]

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