| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C424728-1ml |
1ml |
现货  |
|
| 英文别名 | cccp | 555-60-2 | Carbonyl cyanide 3-chlorophenylhydrazone | (3-Chlorophenyl)hydrazonomalononitrile | Carbonyl cyanide m-chlorophenylhydrazone | Carbonylcyanide-3-chlorophenylhydrazone | Carbonyl cyanide m-chlorophenyl hydrazone | m-Chlorophenyl carbonylcyanide hydrazo |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Carbonyl cyanide 3-chlorophenylhydrazone |
| 生化机理 | 强大的线粒体氧化磷酸化解偶联剂。使质子可透过的线粒体内膜。诱导体外凋亡。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
用途： 抑制临床铜绿假单胞菌中的外排泵 抑制人Beas-2B支气管上皮细胞线粒体的氧化磷酸化活性 制备羰基氰化物间氯苯腙溶液，分析秀丽隐杆线虫的氧化和线粒体应激及线粒体诱导作用 |
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 2-[(3-chlorophenyl)hydrazinylidene]propanedinitrile |
| INCHI | InChI=1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H |
| InChi Key | UGTJLJZQQFGTJD-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC(=CC(=C1)Cl)NN=C(C#N)C#N |
| Isomeric SMILES | C1=CC(=CC(=C1)Cl)NN=C(C#N)C#N |
| PubChem CID | 2603 |
| 分子量 | 204.62 |
| 敏感性 | 对空气敏感 |
|---|---|
| 分子量 | 204.610 g/mol |
| XLogP3 | 3.400 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 2 |
| 精确质量Exact Mass | 204.02 Da |
| 单同位素质量Monoisotopic Mass | 204.02 Da |
| 拓扑极表面积Topological Polar Surface Area | 72.000 Ų |
| 重原子数Heavy Atom Count | 14 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 300.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS06, GHS07 |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H301: 吞咽会中毒 H311: 皮肤接触有毒 H331: 吸入会中毒 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P330: 漱口 P361+P364: 立即脱掉所有沾染的衣服，清洗后方可重新使用。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P316: 立即寻求紧急医疗救助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| Concentration(Compounding value) | 9.0-11.0(mmol/L) |
|---|---|
| Appearance(Orange Liquid) | Pass |
| Record the entire process by video | Conform |
| 1. Xijuan Chao, Dezhi Yao, Chuxuan Chen, Zhiguo Sheng, Benzhan Zhu. (2024) Tetrabromobisphenol A induces neuronal cytotoxicity by inhibiting PINK1-Parkin-mediated mitophagy via upregulating ATF3 expression. SCIENCE OF THE TOTAL ENVIRONMENT, 912 (169175). [PMID:38065503] [10.1016/j.scitotenv.2023.169175] |
| 2. Wei Liu, Tengfei Wang, Liwen Wang, Yan Wang, Sheng Hu, Dating Tian. (2024) A novel near-infrared fluorescent probe for ultrasensitive and visual detection of mitochondrial viscosity. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 304 (123329). [PMID:37683438] [10.1016/j.saa.2023.123329] |
| 3. Zhang Hongzhen, Zhang Chenghua, Xiang Xiaolong, Zhang Qilun, Zhao Wei, Wei Guoyu, Hu Anlong. (2022) Uptake and transport of antibiotic kasugamycin in castor bean (Ricinus communis L.) seedlings. Frontiers in Microbiology, 13 [PMID:36033898] [10.3389/fmicb.2022.948171] |
| 4. Chen Xiaolong, Hu Cuihua, Zhang Yanan, Hao Wenjing, He Xu, Li Qing, Huang Yuxi, Huang Yibing, Chen Yuxin. (2020) Anticancer Activity and Mechanism of Action of kla-TAT Peptide. International Journal of Peptide Research and Therapeutics, 26 (4): (2285-2296). [10.1007/s10989-020-10019-5] |
| 5. Dongyang Xu, Yan Deng, Rongdong Fan, Lei Shi, Jianshan Bai, He Yan. (2019) Coresistance to Benzalkonium Chloride Disinfectant and Heavy Metal Ions in Listeria monocytogenes and Listeria innocua Swine Isolates from China. Foodborne Pathogens and Disease, 16 (10): (696-703). [PMID:31120347] [10.1089/fpd.2018.2608] |
| 1. Xijuan Chao, Dezhi Yao, Chuxuan Chen, Zhiguo Sheng, Benzhan Zhu. (2024) Tetrabromobisphenol A induces neuronal cytotoxicity by inhibiting PINK1-Parkin-mediated mitophagy via upregulating ATF3 expression. SCIENCE OF THE TOTAL ENVIRONMENT, 912 (169175). [PMID:38065503] [10.1016/j.scitotenv.2023.169175] |
| 2. Wei Liu, Tengfei Wang, Liwen Wang, Yan Wang, Sheng Hu, Dating Tian. (2024) A novel near-infrared fluorescent probe for ultrasensitive and visual detection of mitochondrial viscosity. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 304 (123329). [PMID:37683438] [10.1016/j.saa.2023.123329] |
| 3. Zhang Hongzhen, Zhang Chenghua, Xiang Xiaolong, Zhang Qilun, Zhao Wei, Wei Guoyu, Hu Anlong. (2022) Uptake and transport of antibiotic kasugamycin in castor bean (Ricinus communis L.) seedlings. Frontiers in Microbiology, 13 [PMID:36033898] [10.3389/fmicb.2022.948171] |
| 4. Chen Xiaolong, Hu Cuihua, Zhang Yanan, Hao Wenjing, He Xu, Li Qing, Huang Yuxi, Huang Yibing, Chen Yuxin. (2020) Anticancer Activity and Mechanism of Action of kla-TAT Peptide. International Journal of Peptide Research and Therapeutics, 26 (4): (2285-2296). [10.1007/s10989-020-10019-5] |
| 5. Dongyang Xu, Yan Deng, Rongdong Fan, Lei Shi, Jianshan Bai, He Yan. (2019) Coresistance to Benzalkonium Chloride Disinfectant and Heavy Metal Ions in Listeria monocytogenes and Listeria innocua Swine Isolates from China. Foodborne Pathogens and Disease, 16 (10): (696-703). [PMID:31120347] [10.1089/fpd.2018.2608] |
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