氯喹, MRGPRX1 激动剂;TAS2R3 激动剂

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C424619-1ml
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Compound libraries (12326)

基本描述

别名 氯喹盐基 | N4-(7-氯喹啉-4-yl)-N1,N1-二乙基戊烷-1,4-二胺
英文别名 chloroquine | 54-05-7 | Aralen | Chlorochin | Chloraquine | Artrichin | Chloroquina | Chloroquinium | Capquin | Reumachlor | Chemochin | Chlorquin | Clorochina | Malaquin | Bemaco | Arthrochin | Bemasulph | Chingamin | Cidanchin | Cocartrit | Dichinalex | Gontochin | Pfizerquine | Quinachlor | Quinercy
规格或纯度 Moligand™, 10mM in DMSO
英文名称 Chloroquine
储存温度 -80℃储存
运输条件 超低温冰袋运输
作用类型 激动剂
作用机制 MRGPRX1 激动剂;TAS2R3 激动剂

关联靶点(人)

TMEM97 Tchem Sigma 细胞内受体 2(Sigma intracellular receptor 2) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
SIGMAR1 Tclin Sigma 非阿片类细胞内受体 1(Sigma non-opioid intracellular receptor 1) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
MRGPRX1 Tchem Mas相关G蛋白偶联受体成员X1(Mas-related G-protein coupled receptor member X1) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
KCNH2 Tclin 钾电压门控通道亚家族 H 成员 2(Potassium voltage-gated channel subfamily H member 2) (6 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
DHFR Tclin Dihydrofolate reductase (3072 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CACNA1C Tclin Voltage-gated L-type calcium channel alpha-1C subunit (766 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC29A1 Tclin Equilibrative nucleoside transporter 1 (1711 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM4 Tclin Muscarinic acetylcholine receptor M4 (6041 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM5 Tclin Muscarinic acetylcholine receptor M5 (4677 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2B Tclin Alpha-2b adrenergic receptor (4412 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2C Tclin Alpha-2c adrenergic receptor (4876 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA2A Tclin Adenosine A2a receptor (16305 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CTSD Tchem Cathepsin D (3201 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点(其它种属)

Histidine-rich protein (528 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Sigmar1 Sigma opioid receptor (160 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Papain (844 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cckar Cholecystokinin A receptor (90 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pde4d Phosphodiesterase 4D (4 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Abcb1b P-glycoprotein 1 (174 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
pol Human immunodeficiency virus type 1 integrase (9041 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HD1 Histone deacetylase (38 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PMII Plasmepsin 2 (774 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pfmrk Protein kinase Pfmrk (149 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Trichophyton benhamiae (1686 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Streptococcus pneumoniae (31063 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Salmonella typhimurium (15756 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Streptococcus pyogenes (16140 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Enterococcus faecium (13803 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mycobacterium tuberculosis (203094 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Saccharomyces cerevisiae (19171 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Lacticaseibacillus casei (578 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mycobacterium intracellulare (1532 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Aspergillus fumigatus (16427 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Leishmania infantum (5912 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Trypanosoma brucei (78846 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Trypanosoma brucei brucei (13300 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Entamoeba histolytica (2676 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cryptosporidium parvum (1150 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum K1 (762 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Leishmania amazonensis (3813 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Leishmania braziliensis (1091 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Leishmania donovani (89745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Leishmania major (2877 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Leishmania mexicana (936 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Leishmania tropica (461 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Trypanosoma cruzi (99888 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Trichomonas vaginalis (2376 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Giardia intestinalis (1290 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium berghei (192651 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium yoelii (6656 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Human alphaherpesvirus 2 (4932 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Human respirovirus 3 (1674 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 200-191-2
分子类型 小分子
IUPAC Name 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine
INCHI InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21)
InChi Key WHTVZRBIWZFKQO-UHFFFAOYSA-N
Canonical SMILES CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl
Isomeric SMILES CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl
关联CAS 54-05-7
PubChem CID 2719
NSC Number 187208
MeSH Entry Terms Aralen;Arechine;Arequin;Chingamin;Chlorochin;Chloroquine;Chloroquine Sulfate;Chloroquine Sulphate;Khingamin;Nivaquine;Sulfate, Chloroquine;Sulphate, Chloroquine
分子量 319.87

化学和物理性质

敏感性 对空气敏感;对热敏感
比旋光度 -1.0 to +1.0 deg (C=1, methanol)
熔点 91 °C
分子量 319.900 g/mol
XLogP3 4.600
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 3
可旋转键计数Rotatable Bond Count 8
精确质量Exact Mass 319.182 Da
单同位素质量Monoisotopic Mass 319.182 Da
拓扑极表面积Topological Polar Surface Area 28.200 Ų
重原子数Heavy Atom Count 22
形式电荷Formal Charge 0
复杂度Complexity 309.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 1
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性(GHS)

象形图 GHS07
信号词 Warning
危险声明

H302: 吞食有害

预防措施声明

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P270: 使用本产品时,请勿进食、饮水或吸烟。

P330: 漱口

P301+P317: 如果被吞咽:请寻求医疗帮助。

质量标准

Concentration(Compounding value) 9.0-11.0(mmol/L)
Appearance(Colorless Transparent Liquid) Pass
Record the entire process by video Conform

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

此产品的引用文献

1. Xijuan Chao, Dezhi Yao, Chuxuan Chen, Zhiguo Sheng, Benzhan Zhu.  (2024)  Tetrabromobisphenol A induces neuronal cytotoxicity by inhibiting PINK1-Parkin-mediated mitophagy via upregulating ATF3 expression.  SCIENCE OF THE TOTAL ENVIRONMENT,  912  (169175).  [PMID:38065503] [10.1016/j.scitotenv.2023.169175]
2. Xiaolin Zhang, Zhen Dong, Yuanmiao Yang, Chaolong Liu, Jisheng Li, Wenli Sun, Yikang Zhu, Yang Shen, Zhi Wang, Muhan Lü, Hongjuan Cui.  (2023)  Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  [PMID:37870273] [10.1021/acs.jafc.3c01244]
3. Dan Yuan, Qi Li, Qibo Zhang, Feibai Zhou, Qiangzhong Zhao, Mouming Zhao.  (2024)  Enhanced curcumin transportation across epithelial barrier by mucus-permeable soy protein nanoparticles-mediated dual transcytosis pathways.  FOOD CHEMISTRY,  437  (137771).  [PMID:37897825] [10.1016/j.foodchem.2023.137771]
4. Yiqian Zhang, Qianrui Huang, Qisi Xu, Chengsen Jia, Yong Xia.  (2023)  Pimavanserin tartrate induces apoptosis and cytoprotective autophagy and synergizes with chemotherapy on triple negative breast cancer.  BIOMEDICINE & PHARMACOTHERAPY,  168  (115665).  [PMID:37832400] [10.1016/j.biopha.2023.115665]
5. Liu Jin, Chen Yuqian, Chen Huan, Wang Yan, Li Danyang, Zhang Qianqian, Chai Limin, Qiu Yuanjie, Zhang Jia, Shen Nirui, Wang Qingting, Wang Jian, Li Manxiang.  (2023)  Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation.  RESPIRATORY RESEARCH,  24  (1): (1-14).  [PMID:37674165] [10.1186/s12931-023-02526-y]
6. Daxiu Li, Feng Qiu, Ruo Yuan, Yun Xiang.  (2023)  Multiplexed and amplified electrochemical aptasensor for sensitive assay of piperaquine and mefloquine.  SENSORS AND ACTUATORS B-CHEMICAL,  395  (134483).  [10.1016/j.snb.2023.134483]
7. Peixin Wang, Chenqiong Zhao, Hanjing Zhou, Xiaona Huang, Hanqi Ying, Songying Zhang, Yibin Pan, Haiyan Zhu.  (2023)  Dysregulation of Histone Deacetylases Inhibits Trophoblast Growth during Early Placental Development Partially through TFEB-Dependent Autophagy-Lysosomal Pathway.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  24  (15): (11899).  [PMID:37569278] [10.3390/ijms241511899]
8. Zhe Chen, Jia-Yu Zhang, Qian Jiang, Yang-Yang Bao, Zhi-Mei Li, Shui-Hong Zhou, Jiang-Tao Zhong, Zi-Ming Fu, Zai-Zai Cao, Jun Fan, Hong-Tian Yao.  (2023)  Pepsin Increases the Proliferation of Vocal Cord Leukoplakia Epithelial Cells by Inducing Autophagy.  OTOLARYNGOLOGY-HEAD AND NECK SURGERY,  [PMID:37264983] [10.1002/ohn.390]
9. Yanli Zhang, Yulin Zhang, Ye Lei, Junrong Wu, Yiyuan Kang, Shuo Zheng, Longquan Shao.  (2023)  MDM2 upregulation induces mitophagy deficiency via Mic60 ubiquitination in fetal microglial inflammation and consequently neuronal DNA damage caused by exposure to ZnO-NPs during pregnancy.  JOURNAL OF HAZARDOUS MATERIALS,  457  (131750).  [PMID:37315416] [10.1016/j.jhazmat.2023.131750]
10. Haili Xiao, Chao Wei, Huiying Liu, Zhiqiang Li, Cihua Zheng, Jun Luo.  (2023)  Lentinan alleviates sciatic nerve injury by promoting autophagy to remove myelin fragments.  PHYTOTHERAPY RESEARCH,  [PMID:37165703] [10.1002/ptr.7862]
11. Xin Chang, Chang Liu, Yu-Mo Han, Qiu-Ling Li, Bin Guo, Hu-Lin Jiang.  (2023)  Efficient transfected liposomes co-loaded with pNrf2 and pirfenidone improves safe delivery for enhanced pulmonary fibrosis reversion.  Molecular Therapy-Nucleic Acids,  32  (415-431).  [PMID:37159604] [10.1016/j.omtn.2023.04.006]
12. Shi Hanqiang, Xiong Lie, Yan Guang, Du Shuqin, Liu Jie, Shi Yanbo.  (2023)  Susceptibility of cervical cancer to dihydroartemisinin-induced ferritinophagy-dependent ferroptosis.  Frontiers in Molecular Biosciences,  10  [PMID:37065442] [10.3389/fmolb.2023.1156062]
13. Jinzhe Li, Chuyun Fu, Qiufeng Lin, Tao Zeng, Da Wang, Xinwen Huang, Shuang Song, Cong Li, Feilong Dong.  (2023)  Fe(VI) activation system mediated by a solar-driven TiO2 nanotubes electrode for CLQ degradation: Performances, mechanisms and pathways.  JOURNAL OF HAZARDOUS MATERIALS,  452  (131274).  [PMID:36989796] [10.1016/j.jhazmat.2023.131274]
14. T Wang, Q Wang, G Pan, G Jia, X Li, C Wang, L Zhang, C Zuo.  (2023)  ASIC1a involves the acid-mediated activation of pancreatic stellate cells associated with autophagy induction.  PHYSIOLOGICAL RESEARCH,  72  (1): (49-57).  [PMID:36545882] [10.33549/physiolres.934950]
15. Yingbo Jia, Jing Hu, Chaojie Zhu, Zijing Li, Xinyu Yang, Ruitian Liu, Linghui Zeng, Lingxiao Zhang.  (2023)  Engineered NanoAlum from aluminum turns cold tumor hot for potentiating cancer metalloimmunotherapy.  JOURNAL OF CONTROLLED RELEASE,  354  (770).  [PMID:36702259] [10.1016/j.jconrel.2023.01.043]
16. Xu Chi, Jiang Shuyun, Ma Xingyu, Jiang Zeyong, Pan Youguang, Li Xiang, Zhang Liying, Zhou Hao, Chen Shen, Xing Xiumei, Chen Liping, Fu Wenfan, Wang Qing, Chen Wen, Li Daochuan.  (2023)  CRISPR-based DNA methylation editing of NNT rescues the cisplatin resistance of lung cancer cells by reducing autophagy.  ARCHIVES OF TOXICOLOGY,  97  (2): (441-456).  [PMID:36336710] [10.1007/s00204-022-03404-0]
17. Shiqi Zhu, Haimei Wen, Wenling Wang, Yong Chen, Fengmei Han, Wentao Cai.  (2023)  Anti-hepatitis B virus activity of lithospermic acid, a polyphenol from Salvia miltiorrhiza, in vitro and in vivo by autophagy regulation.  JOURNAL OF ETHNOPHARMACOLOGY,  302  (115896).  [PMID:36334815] [10.1016/j.jep.2022.115896]
18. Xiaonan Chen, Yiqing Zou, Shuqi Zhang, Pengchao Fang, Shuxuan Li, Pengyu Li, Yingying Sun, Gang Yuan, Haiyan Hu.  (2022)  Multi-functional vesicles improve Helicobacter pylori eradication by a comprehensive strategy based on complex pathological microenvironment.  Acta Pharmaceutica Sinica B,  12  (3498).  [PMID:36176916] [10.1016/j.apsb.2022.05.014]
19. Yi Wang, Jingwen Xu, Yihai Wang, Limin Xiang, Xiangjiu He.  (2022)  S-20, a steroidal saponin from the berries of black nightshade, exerts anti-multidrug resistance activity in K562/ADR cells through autophagic cell death and ERK activation.  Food & Function,  13  (4): (2200-2215).  [PMID:35119449] [10.1039/D1FO03191K]
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36. Lingmin Zhang, Qingqing Xia, Yingying Zhou, Jie Li.  (2019)  Endoplasmic reticulum stress and autophagy contribute to cadmium-induced cytotoxicity in retinal pigment epithelial cells.  TOXICOLOGY LETTERS,  311  (105).  [PMID:31054874] [10.1016/j.toxlet.2019.05.001]
37. Xiaoxiao Liang, Zhiqiang Hou, Yuanlong Xie, Feifei Yan, Sisi Li, Xiaobin Zhu, Lin Cai.  (2019)  Icariin promotes osteogenic differentiation of bone marrow stromal cells and prevents bone loss in OVX mice via activating autophagy.  JOURNAL OF CELLULAR BIOCHEMISTRY,  120  (8): (13121-13132).  [PMID:30887562] [10.1002/jcb.28585]
38. Shuang E, Quan-Xing Mao, Xiao-Li Yuan, Xiao-Lei Kong, Xu-Wei Chen, Jian-Hua Wang.  (2018)  Targeted imaging of the lysosome and endoplasmic reticulum and their pH monitoring with surface regulated carbon dots.  Nanoscale,  10  (26): (12788-12796).  [PMID:29947397] [10.1039/C8NR03453B]
39. Shaohong Fang,Xin Wan,Xiaoyi Zou,Song Sun,Xinran Hao,Chenchen Liang,Zhenming Zhang,Fangni Zhang,Bo Sun,Hulun Li,Bo Yu.  (2021-01-20)  Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway..  Cell death & disease,  12  ((1)): (88-88).  [PMID:33462182]

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