| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C408857-1ml |
1ml |
现货  |
|
| 英文别名 | Benzoic acid, 4-[4-[[5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]- |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | C646 |
| 生化机理 | C646 是组蛋白乙酰转移酶的抑制剂，在无细胞试验中对 p300 的Ki值为 400 nM。与其他乙酰转移酶相比，它对 p300 具有优先选择性。C646 可诱导细胞周期停滞、细胞凋亡和自噬。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | E1A 结合蛋白 p300 的抑制剂 |
| 产品介绍 |
C646 是一种histone acetyltransferase抑制剂，抑制p300，无细胞试验中Ki为400 nM，相比于其它乙酰转移酶，优先作用于p300。C646 可诱导细胞周期阻滞、细胞凋亡与自噬。 Information C646 C646 is an inhibitor for histone acetyltransferase , and inhibits p300 with a K i of 400 nM in a cell-free assay. Preferentially selective for p300 versus other acetyltransferases. C646 induces cell cycle arrest, apoptosis and autophagy . C646 is an inhibitor for histone acetyltransferase, inhibits p300 with a Ki of 400 nM and is selective versus other acetyltransferases. C646 produces 86% inhibition of p300 in vitro at 10 μM. C646 is a classical reversible p300 inhibitor. C646 treatment (25μM) reduces histone H3 and H4 acetylation levels and abrogates TSA-induced acetylation in cells. C646 (20μM) induces apoptosis in androgen-sensitive and castration-resistant prostate cancer cell lines by interfering with AR and NF-kB pathways. C646 blocks dynamic acetylation of H3K4me3 globally in mouse and fly cells, and locally across the promoter and start-site of inducible genes in the mouse, thereby disrupting RNA polymerase II association and the activation of these genes. In vivo C646 infused into the ILPFC immediately after weak extinction training enhances the consolidation of fear extinction memory. C646 attenuates mechanical allodynia and thermal hyperalgesia, accompanied by a suppressed COX-2 expression, in the spinal cord. cell lines： Concentrations：~25 μM Incubation Time：1 to 3 hr Powder Purity:≥97% |
| 分子类型 | 小分子 |
|---|---|
| Isomeric SMILES | CC1=CC(=C(C=C1C)[N+](=O)[O-])C2=CC=C(O2)/C=C\3/C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C |
| 分子量 | 445.42 |
| Reaxy-Rn | 20607912 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20607912&ln= |
| 象形图 | GHS09 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响 |
| 预防措施声明 |
P273: 避免释放到环境中。 P501: 将内容物/容器处理到。。。 P391: 收集溢出物 |
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