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塞来昔布, 环氧化酶-2 抑制剂

选择性环氧合酶2（COX-2）抑制剂。非甾体抗炎药。
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货号 (SKU) 包装规格 是否现货 价格 数量
C129279-100mg
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C129279-1g
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C129279-5g
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C129279-10g
 10g 现货 Stock Image
C129279-25g
 25g 现货 Stock Image
C129279-100g
 100g 现货 Stock Image
C129279-500g
 500g 期货 Stock Image
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carbonic anhydrase 12 Inhibitor (16) COX (259) COX-1 Inhibitor (30) COX-2 Inhibitor (41) Immunology/Inflammation (1941)
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基本描述

别名 塞内昔布 | 4-[5-(4-甲苯基)-3-(三氟甲基)-1H-吡唑-1-基]甲磺酰胺 | 5-(4-甲苯基)-1-(4-磺酰基苯基)-3-(三氟甲基)吡唑
英文别名 JCX84Q7J1L | 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide | CELECOXIB (EP MONOGRAPH) | CELECOXIB [EP MONOGRAPH] | CELECOXIB [MART.] | CELECOXIB [USP MONOGRAPH] | DivK1c_000893 | DTXSID0022777 | KBio1_000893 | Celecoxib 100 mg |
规格或纯度 Moligand™, ≥99%
英文名称 Celecoxib
生化机理 塞来昔布是一种选择性环氧化酶 2（Cox-2）抑制剂（IC50 = 40 nM），对 Cox-1 的敏感性较低。塞来昔布是一种选择性环氧化酶-2（Cox-2）抑制剂（IC50 = 40 nM），对 Cox-1 的敏感性较低。塞来昔布对鼻咽癌（NPC）细胞系具有抗增殖作用，包括 HNE1（IC50 = 32.86 μM）和 CNE1-LMP1（IC50 = 61.31 μM）。非甾体抗炎药。增强体内肿瘤细胞的凋亡。口服有效。
储存温度 -20°C储存
运输条件 超低温冰袋运输
作用类型 抑制剂
作用机制 环氧化酶-2 抑制剂
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

Celecoxib是环氧合酶-2(COX-2)选择性抑制剂，IC50为40 nM。A selective Cox-2 inhibitor

Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM.
A selective Cox-2 inhibitor

产品属性

ALogP 3.4

关联靶点（人）

CYP2D6 Tclin 细胞色素 P450 2D6(Cytochrome P450 2D6) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
MT-CO2 Tchem 细胞色素 c 氧化酶亚基 2(Cytochrome c oxidase subunit 2) (3 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA5A Tclin 碳酸酐酶 5A，线粒体(Carbonic anhydrase 5A, mitochondrial) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PTGES Tchem 前列腺素E合酶(Prostaglandin E synthase) (3 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HDAC6 Tclin 组蛋白去乙酰化酶6(Histone deacetylase 6) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PTGS1 Tclin 前列腺素 G/H 合酶 1(Prostaglandin G/H synthase 1) (10 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PTGS2 Tclin 前列腺素 G/H 合酶 2(Prostaglandin G/H synthase 2) (172 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA5B Tclin 碳酸酐酶 5B，线粒体(Carbonic anhydrase 5B, mitochondrial) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA6 Tclin 碳酸酐酶6(Carbonic anhydrase 6) (3 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA13 Tclin 碳酸酐酶13(Carbonic anhydrase 13) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA2 Tclin 碳酸酐酶2(Carbonic anhydrase 2) (48 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA4 Tclin 碳酸酐酶4(Carbonic anhydrase 4) (4 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA12 Tclin 碳酸酐酶12(Carbonic anhydrase 12) (8 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA14 Tclin 碳酸酐酶14(Carbonic anhydrase 14) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CA9 Tclin 碳酸酐酶9(Carbonic anhydrase 9) (12 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PDE5A Tclin Phosphodiesterase 5A (5113 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
INSR Tclin Insulin receptor (5558 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CRHR1 Tclin Corticotropin releasing factor receptor 1 (2996 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GCGR Tclin Glucagon receptor (2563 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Htr7 Serotonin 7 (5-HT7) receptor (19 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Agtr2 Angiotensin II type 2 (AT-2) receptor (803 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ca7 Carbonic anhydrase VII (3 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Sigmar1 Sigma opioid receptor (160 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGES Prostaglandin E synthase (10 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cruzipain (33337 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cckar Cholecystokinin A receptor (90 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ntsr1 Neurotensin receptor 1 (48 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pde4d Phosphodiesterase 4D (4 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Bdkrb1 Bradykinin B1 receptor (77 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ppard Peroxisome proliferator-activated receptor delta (358 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ca13 Carbonic anhydrase XIII (322 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA4 Carbonic anhydrase IV (1713 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hdac1 Histone deacetylase 1 (93 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDE6A Phosphodiesterase 6A (40 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HD1 Histone deacetylase (38 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hcar2 Hydroxycarboxylic acid receptor 2 (55 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Carbonic anhydrase (69 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Salmonella typhimurium (15756 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus epidermidis (22802 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mycolicibacterium smegmatis (8003 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Canis familiaris (36305 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Oryctolagus cuniculus (11301 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
L1210 (27553 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Vero (26788 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
C6 (2371 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
B16-F10 (4610 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MC9 (107 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
norA Quinolone resistance protein norA (2171 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ca15 Carbonic anhydrase 15 (173 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MT-CO1 Cytochrome c oxidase subunit 1 (72 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504750587
EC号 685-962-5
分子类型 小分子
IUPAC Name 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
INCHI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
InChi Key RZEKVGVHFLEQIL-UHFFFAOYSA-N
Canonical SMILES CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F
Isomeric SMILES CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F
WGK Germany 3
RTECS DB2944937
关联CAS 169590-42-5
PubChem CID 2662
NSC Number 719627
MeSH Entry Terms 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide;Celebrex;celecoxib;SC 58635;SC-58635;SC58635
分子量 381.37

化学和物理性质

溶解性 Soluble in DMSO (76 mg/ml at 25 °C), methanol, ethanol (33 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and dichloromethane., Soluble in DMSO (76 mg/ml at 25 °C), methanol, ethanol (33 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and dichloromethane
敏感性 对热、光线敏感
熔点 163 °C
分子量 381.400 g/mol
XLogP3 3.400
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 7
可旋转键计数Rotatable Bond Count 3
精确质量Exact Mass 381.076 Da
单同位素质量Monoisotopic Mass 381.076 Da
拓扑极表面积Topological Polar Surface Area 86.400 Ų
重原子数Heavy Atom Count 26
形式电荷Formal Charge 0
复杂度Complexity 577.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS08
信号词 Danger
危险声明

H360: 可能损害生育力或未出生的孩子
预防措施声明

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P203: 使用前，获取、阅读并遵守所有安全说明。

P318: 如果暴露或担心，请就医。
WGK Germany 3
RTECS DB2944937
Merck Index 1956

 SDS英文版

质量标准

Carbon by Elemental Analysis 52.5-54（%）
Purity(HPLC) 98-100（%）
Nitrogen by Elemental Analysis 10.4-11.5（%）
Appearance（C129279) White to off-white solid
NMR spectrum Conforms to Structure

 质量标准

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C of A & Other Certificates(BSE/TSE, COO):
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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到19个结果

批号(Lot Number) 证书类型 日期 货号
I2406048 分析证书 24-06-13 C129279
H2231292 分析证书 24-06-13 C129279
I2208675 分析证书 24-06-13 C129279
D2410231 分析证书 24-03-26 C129279
D2410254 分析证书 24-03-26 C129279
A2404446 分析证书 23-12-04 C129279
A2404449 分析证书 23-12-04 C129279
A2404451 分析证书 23-12-04 C129279
L2115371 分析证书 23-09-22 C129279
H2201077 分析证书 22-08-04 C129279
H2201078 分析证书 22-08-04 C129279
G2308175 分析证书 22-07-04 C129279
K2309018 分析证书 22-07-04 C129279
K2309019 分析证书 22-07-04 C129279
L2312029 分析证书 22-07-04 C129279
D2411085 分析证书 22-07-04 C129279
J2422032 分析证书 22-07-04 C129279
H2231291 分析证书 22-07-04 C129279
H2231294 分析证书 22-07-04 C129279

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此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?
1. Yongjing Cao, Juan Li, Qiangwei Liang, Jiayu Yang, Xiaojie Zhang, Juntao Zhang, Min An, Jiawei Bi, Yanhua Liu.  (2023)  Tumor Microenvironment Sequential Drug/Gene Delivery Nanosystem for Realizing Multistage Boosting of Cancer–Immunity Cycle on Cancer Immunotherapy.  ACS Applied Materials & Interfaces,  [PMID:37963093] [10.1021/acsami.3c11394]
2. Xiaoyu Han, Fan Wang, Jieliang Shen, Shuyu Chen, Pengcheng Xiao, Ying Zhu, Weiwei Yi, Zhengyu Zhao, Zhengwei Cai, Wenguo Cui, Dingqun Bai.  (2023)  Ultrasound Nanobubble Coupling Agent for Effective Noninvasive Deep-Layer Drug Delivery.  ADVANCED MATERIALS,  (2306993).  [PMID:37851922] [10.1002/adma.202306993]
3. Shouchao Xu, Jiehong Yang, Haitong Wan, Li Yu, Yu He.  (2023)  Combination of Radix Astragali and Safflower Promotes Angiogenesis in Rats with Ischemic Stroke via Silencing PTGS2.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  24  (3): (2126).  [PMID:36768450] [10.3390/ijms24032126]
4. Chen An, Cai Peishan, Luo Minqian, Guo Minshan, Cai Ting.  (2023)  Melt Crystallization of Celecoxib-Carbamazepine Cocrystals with the Synchronized Release of Drugs.  PHARMACEUTICAL RESEARCH,  40  (2): (567-577).  [PMID:36348133] [10.1007/s11095-022-03427-3]
5. Xin Zhao, Lingyu Li, Shuang Li, Jinyu Liu, Hongya Wang, Yulin Lin, Dayong Cai.  (2022)  Diammonium glycyrrhizinate ameliorates portal hypertension by regulating portal macrophage oxidation and superoxide dismutase 3.  EUROPEAN JOURNAL OF PHARMACOLOGY,  929  (175115).  [PMID:35738453] [10.1016/j.ejphar.2022.175115]
6. Cong Zhang, Yuzhen Lu, Yingying Song, Liang Chen, Junjie Hu, Yan Meng, Xin Chen, Shan Li, Guohua Zheng, Zhenpeng Qiu.  (2022)  Celecoxib attenuates hepatosteatosis by impairing de novo lipogenesis via Akt-dependent lipogenic pathway.  JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,  26  (14): (3995-4006).  [PMID:35713152] [10.1111/jcmm.17435]
7. Jialiang Lin, Junchao Huang, Jiang Wu, Bo Tang, Congbin Li, Haijun Xiao.  (2022)  Poly(lactic acid-co-glycolic acid)-based celecoxib extended-release microspheres for the local treatment of traumatic heterotopic ossification.  JOURNAL OF BIOMATERIALS APPLICATIONS,  [PMID:35043696] [10.1177/08853282211056937]
8. Changyou Yu, Menghui Yao, Yiming Ma, Yanbo Liu, Shilin Guo, Shijie Xu, Sohrab Rohani, Mingyang Chen, Junbo Gong.  (2021)  Design of the spherical agglomerate size in crystallization by developing a two-step bridging mechanism and the model.  AICHE JOURNAL,  68  (2): (e17526).  [10.1002/aic.17526]
9. Muhammad Asim Farooq, Amna Jabeen, Bo Wang.  (2021)  Formulation, optimization, and characterization of whey protein isolate nanocrystals for celecoxib delivery.  JOURNAL OF MICROENCAPSULATION,  [PMID:33896352] [10.1080/02652048.2021.1915398]

参考文献

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2. Naji S et al..  (2019)  Cadmium Induces Migration of Colon Cancer Cells: Roles of Reactive Oxygen Species, P38 and Cyclooxygenase-2..  Cell Physiol Biochem,  52  (6): (1517-1534).  [PMID:31120230]
3. Chen L et al..  (2017)  L161982 alleviates collagen-induced arthritis in mice by increasing Treg cells and down-regulating Interleukin-17 and monocyte-chemoattractant protein-1 levels..  BMC Musculoskelet Disord,  18  (462).  [PMID:29145862]
4. Harati R et al..  (2020)  Loss of miR-101-3p Promotes Transmigration of Metastatic Breast Cancer Cells through the Brain Endothelium by Inducing COX-2/MMP1 Signaling..  Pharmaceuticals (Basel),  13  (7): [PMID:32645833]
5. Dey R & Bishayi B.  (2020)  TLR-2 neutralization potentiates microglial M1 to M2 switching by the combinatorial treatment of ciprofloxacin and dexamethasone during S. aureus infection..  J Neuroimmunol,  344  (577262).  [PMID:32450430]
6. Yongjing Cao, Juan Li, Qiangwei Liang, Jiayu Yang, Xiaojie Zhang, Juntao Zhang, Min An, Jiawei Bi, Yanhua Liu.  (2023)  Tumor Microenvironment Sequential Drug/Gene Delivery Nanosystem for Realizing Multistage Boosting of Cancer–Immunity Cycle on Cancer Immunotherapy.  ACS Applied Materials & Interfaces,  [PMID:37963093] [10.1021/acsami.3c11394]
7. Xiaoyu Han, Fan Wang, Jieliang Shen, Shuyu Chen, Pengcheng Xiao, Ying Zhu, Weiwei Yi, Zhengyu Zhao, Zhengwei Cai, Wenguo Cui, Dingqun Bai.  (2023)  Ultrasound Nanobubble Coupling Agent for Effective Noninvasive Deep-Layer Drug Delivery.  ADVANCED MATERIALS,  (2306993).  [PMID:37851922] [10.1002/adma.202306993]
8. Shouchao Xu, Jiehong Yang, Haitong Wan, Li Yu, Yu He.  (2023)  Combination of Radix Astragali and Safflower Promotes Angiogenesis in Rats with Ischemic Stroke via Silencing PTGS2.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  24  (3): (2126).  [PMID:36768450] [10.3390/ijms24032126]
9. Chen An, Cai Peishan, Luo Minqian, Guo Minshan, Cai Ting.  (2023)  Melt Crystallization of Celecoxib-Carbamazepine Cocrystals with the Synchronized Release of Drugs.  PHARMACEUTICAL RESEARCH,  40  (2): (567-577).  [PMID:36348133] [10.1007/s11095-022-03427-3]
10. Xin Zhao, Lingyu Li, Shuang Li, Jinyu Liu, Hongya Wang, Yulin Lin, Dayong Cai.  (2022)  Diammonium glycyrrhizinate ameliorates portal hypertension by regulating portal macrophage oxidation and superoxide dismutase 3.  EUROPEAN JOURNAL OF PHARMACOLOGY,  929  (175115).  [PMID:35738453] [10.1016/j.ejphar.2022.175115]
11. Cong Zhang, Yuzhen Lu, Yingying Song, Liang Chen, Junjie Hu, Yan Meng, Xin Chen, Shan Li, Guohua Zheng, Zhenpeng Qiu.  (2022)  Celecoxib attenuates hepatosteatosis by impairing de novo lipogenesis via Akt-dependent lipogenic pathway.  JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,  26  (14): (3995-4006).  [PMID:35713152] [10.1111/jcmm.17435]
12. Jialiang Lin, Junchao Huang, Jiang Wu, Bo Tang, Congbin Li, Haijun Xiao.  (2022)  Poly(lactic acid-co-glycolic acid)-based celecoxib extended-release microspheres for the local treatment of traumatic heterotopic ossification.  JOURNAL OF BIOMATERIALS APPLICATIONS,  [PMID:35043696] [10.1177/08853282211056937]
13. Changyou Yu, Menghui Yao, Yiming Ma, Yanbo Liu, Shilin Guo, Shijie Xu, Sohrab Rohani, Mingyang Chen, Junbo Gong.  (2021)  Design of the spherical agglomerate size in crystallization by developing a two-step bridging mechanism and the model.  AICHE JOURNAL,  68  (2): (e17526).  [10.1002/aic.17526]
14. Muhammad Asim Farooq, Amna Jabeen, Bo Wang.  (2021)  Formulation, optimization, and characterization of whey protein isolate nanocrystals for celecoxib delivery.  JOURNAL OF MICROENCAPSULATION,  [PMID:33896352] [10.1080/02652048.2021.1915398]

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