Porcupine - 干细胞及 Wnt 通路 - 按“信号通路”分类

IWP-2,PORCN抑制剂

规格或纯度 :

≥98%

CAS号: 686770-61-6

分子式: C₂₂H₁₈N₄O₂S₃ 分子量: 466.6

IUPAC Name: N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide

SMILES: CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4

InChIKey: WRKPZSMRWPJJDH-UHFFFAOYSA-N

InChI: 1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)

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IWP L6

规格或纯度 :

≥98%(HPLC)

CAS号: 1427782-89-5

分子式: C₂₅H₂₀N₄O₂S₂ 分子量: 472.58

IUPAC Name: 2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(5-phenylpyridin-2-yl)acetamide

SMILES: C1CSC2=C1N=C(N(C2=O)C3=CC=CC=C3)SCC(=O)NC4=NC=C(C=C4)C5=CC=CC=C5

InChIKey: QESQGTFWEQMCMH-UHFFFAOYSA-N

InChI: 1S/C25H20N4O2S2/c30-22(28-21-12-11-18(15-26-21)17-7-3-1-4-8-17)16-33-25-27-20-13-14-32-23(20)24(31)29(25)19-9-5-2-6-10-19/h1-12,15H,13-14,16H2,(H,26,28,30)

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LGK 974

规格或纯度 :

Moligand™

≥98%

CAS号: 1243244-14-5

分子式: C₂₃H₂₀N₆O 分子量: 396.4

IUPAC Name: 2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide

SMILES: CC1=CC(=CN=C1C2=CC(=NC=C2)C)CC(=O)NC3=NC=C(C=C3)C4=NC=CN=C4

InChIKey: XXYGTCZJJLTAGH-UHFFFAOYSA-N

InChI: 1S/C23H20N6O/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20/h3-10,12-14H,11H2,1-2H3,(H,27,29,30)

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Porcn-IN-1

规格或纯度 :

≥98%

CAS号: 2036044-77-4 Compound CID : 132578555

分子式: C₂₅H₁₉FN₄O 分子量: 410.44

IUPAC Name: N-[[5-fluoro-6-(2-methylpyridin-4-yl)pyridin-3-yl]methyl]-9H-carbazole-2-carboxamide

SMILES: CC1=NC=CC(=C1)C2=C(C=C(C=N2)CNC(=O)C3=CC4=C(C=C3)C5=CC=CC=C5N4)F

InChIKey: GOMFFTZBKYVUOE-UHFFFAOYSA-N

InChI: 1S/C25H19FN4O/c1-15-10-17(8-9-27-15)24-21(26)11-16(13-28-24)14-29-25(31)18-6-7-20-19-4-2-3-5-22(19)30-23(20)12-18/h2-13,30H,14H2,1H3,(H,29,31)

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ETC-159

规格或纯度 :

Moligand™

≥98%

CAS号: 1638250-96-0

分子式: C₁₉H₁₇N₇O₃ 分子量: 391.38

IUPAC Name: 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(6-phenylpyridazin-3-yl)acetamide

SMILES: CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(=O)NC3=NN=C(C=C3)C4=CC=CC=C4

InChIKey: QTRXIFVSTWXRJJ-UHFFFAOYSA-N

InChI: 1S/C19H17N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-20-17)10-15(27)21-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,21,23,27)

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IWP-O1

规格或纯度 :

≥98%

CAS号: 2074607-48-8

分子式: C₂₆H₂₀N₆O 分子量: 432.48

IUPAC Name: N-(5-phenylpyridin-2-yl)-2-(5-phenyl-4-pyridin-4-yltriazol-1-yl)acetamide

SMILES: C1=CC=C(C=C1)C2=CN=C(C=C2)NC(=O)CN3C(=C(N=N3)C4=CC=NC=C4)C5=CC=CC=C5

InChIKey: GYYDQHBKIHQHEB-UHFFFAOYSA-N

InChI: 1S/C26H20N6O/c33-24(29-23-12-11-22(17-28-23)19-7-3-1-4-8-19)18-32-26(21-9-5-2-6-10-21)25(30-31-32)20-13-15-27-16-14-20/h1-17H,18H2,(H,28,29,33)

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GNF-6231

规格或纯度 :

Moligand™

≥98%

CAS号: 1243245-18-2

分子式: C₂₄H₂₅FN₆O₂ 分子量: 448.49

IUPAC Name: N-[5-(4-acetylpiperazin-1-yl)pyridin-2-yl]-2-[6-(2-fluoropyridin-4-yl)-5-methylpyridin-3-yl]acetamide

SMILES: CC1=CC(=CN=C1C2=CC(=NC=C2)F)CC(=O)NC3=NC=C(C=C3)N4CCN(CC4)C(=O)C

InChIKey: AXXNRMISICMFNS-UHFFFAOYSA-N

InChI: 1S/C24H25FN6O2/c1-16-11-18(14-28-24(16)19-5-6-26-21(25)13-19)12-23(33)29-22-4-3-20(15-27-22)31-9-7-30(8-10-31)17(2)32/h3-6,11,13-15H,7-10,12H2,1-2H3,(H,27,29,33)

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ETC-159

规格或纯度 :

Moligand™

10mM in DMSO

CAS号: 1638250-96-0

分子式: C₁₉H₁₇N₇O₃ 分子量: 391.38

IUPAC Name: 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(6-phenylpyridazin-3-yl)acetamide

SMILES: CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(=O)NC3=NN=C(C=C3)C4=CC=CC=C4

InChIKey: QTRXIFVSTWXRJJ-UHFFFAOYSA-N

InChI: 1S/C19H17N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-20-17)10-15(27)21-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,21,23,27)

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GNF-6231

规格或纯度 :

Moligand™

10mM in DMSO

CAS号: 1243245-18-2

分子式: C₂₄H₂₅FN₆O₂ 分子量: 448.49

IUPAC Name: N-[5-(4-acetylpiperazin-1-yl)pyridin-2-yl]-2-[6-(2-fluoropyridin-4-yl)-5-methylpyridin-3-yl]acetamide

SMILES: CC1=CC(=CN=C1C2=CC(=NC=C2)F)CC(=O)NC3=NC=C(C=C3)N4CCN(CC4)C(=O)C

InChIKey: AXXNRMISICMFNS-UHFFFAOYSA-N

InChI: 1S/C24H25FN6O2/c1-16-11-18(14-28-24(16)19-5-6-26-21(25)13-19)12-23(33)29-22-4-3-20(15-27-22)31-9-7-30(8-10-31)17(2)32/h3-6,11,13-15H,7-10,12H2,1-2H3,(H,27,29,33)

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IWP L6

规格或纯度 :

10mM in DMSO

CAS号: 1427782-89-5

分子式: C₂₅H₂₀N₄O₂S₂ 分子量: 472.58

IUPAC Name: 2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(5-phenylpyridin-2-yl)acetamide

SMILES: C1CSC2=C1N=C(N(C2=O)C3=CC=CC=C3)SCC(=O)NC4=NC=C(C=C4)C5=CC=CC=C5

InChIKey: QESQGTFWEQMCMH-UHFFFAOYSA-N

InChI: 1S/C25H20N4O2S2/c30-22(28-21-12-11-18(15-26-21)17-7-3-1-4-8-17)16-33-25-27-20-13-14-32-23(20)24(31)29(25)19-9-5-2-6-10-19/h1-12,15H,13-14,16H2,(H,26,28,30)

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IWP-O1

规格或纯度 :

10mM in DMSO

CAS号: 2074607-48-8

分子式: C₂₆H₂₀N₆O 分子量: 432.48

IUPAC Name: N-(5-phenylpyridin-2-yl)-2-(5-phenyl-4-pyridin-4-yltriazol-1-yl)acetamide

SMILES: C1=CC=C(C=C1)C2=CN=C(C=C2)NC(=O)CN3C(=C(N=N3)C4=CC=NC=C4)C5=CC=CC=C5

InChIKey: GYYDQHBKIHQHEB-UHFFFAOYSA-N

InChI: 1S/C26H20N6O/c33-24(29-23-12-11-22(17-28-23)19-7-3-1-4-8-19)18-32-26(21-9-5-2-6-10-21)25(30-31-32)20-13-15-27-16-14-20/h1-17H,18H2,(H,28,29,33)

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IWP-2

规格或纯度 :

2mM in DMSO

CAS号: 686770-61-6

分子式: C₂₂H₁₈N₄O₂S₃ 分子量: 466.6

IUPAC Name: N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide

SMILES: CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4

InChIKey: WRKPZSMRWPJJDH-UHFFFAOYSA-N

InChI: 1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)

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