MAP4K - MAPK/ERK 信号通路 - 按“信号通路”分类

NG25,TGF-β活化激酶（TAK1）抑制剂

规格或纯度 :

≥98%

CAS号: 1315355-93-1

分子式: C₂₉H₃₀F₃N₅O₂ 分子量: 537.58

IUPAC Name: N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide

SMILES: CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)OC4=C5C=CNC5=NC=C4)C(F)(F)F

InChIKey: SMPGEBOIKULBCT-UHFFFAOYSA-N

InChI: 1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11,16-17H,3,12-15,18H2,1-2H3,(H,33,34)(H,35,38)

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TL4-12,MAP4K2（GCK）抑制剂

规格或纯度 :

≥96%(HPLC)

CAS号: 1620820-12-3 Compound CID : 134812827

分子式: C₂₅H₂₇F₃N₆O₂ 分子量: 500.53

IUPAC Name: 4-methyl-3-[6-(methylamino)pyrimidin-4-yl]oxy-N-[3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]benzamide

SMILES: CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3CCN(CC3)C)OC4=NC=NC(=C4)NC

InChIKey: HXKJJIMUMNPQQY-UHFFFAOYSA-N

InChI: 1S/C25H27F3N6O2/c1-16-4-5-17(10-21(16)36-23-14-22(29-2)30-15-31-23)24(35)32-19-11-18(25(26,27)28)12-20(13-19)34-8-6-33(3)7-9-34/h4-5,10-15H,6-9H2,1-3H3,(H,32,35)(H,29,30,31)

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PF 06260933 二盐酸盐

规格或纯度 :

≥98%(HPLC)

CAS号: 1883548-86-4 Compound CID : 118701007

分子式: C₁₆H₁₃ClN₄.₂HCl 分子量: 369.68

IUPAC Name: 5-(6-aminopyridin-3-yl)-3-(4-chlorophenyl)pyridin-2-amine;dihydrochloride

SMILES: C1=CC(=CC=C1C2=C(N=CC(=C2)C3=CN=C(C=C3)N)N)Cl.Cl.Cl

InChIKey: VRQXEOPUAQLBQI-UHFFFAOYSA-N

InChI: 1S/C16H13ClN4.2ClH/c17-13-4-1-10(2-5-13)14-7-12(9-21-16(14)19)11-3-6-15(18)20-8-11;;/h1-9H,(H2,18,20)(H2,19,21);2*1H

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DMX-5084

规格或纯度 :

≥98%

CAS号: 2306178-56-1

分子式: C₂₁H₁₉N₃O₃ 分子量: 361.39

IUPAC Name: 5-[4-(2-methoxyethoxy)phenyl]-7-phenyl-3H-pyrrolo[2,3-d]pyrimidin-4-one

SMILES: COCCOC1=CC=C(C=C1)C2=CN(C3=C2C(=O)NC=N3)C4=CC=CC=C4

InChIKey: FUSHFOGORKZNNQ-UHFFFAOYSA-N

InChI: 1S/C21H19N3O3/c1-26-11-12-27-17-9-7-15(8-10-17)18-13-24(16-5-3-2-4-6-16)20-19(18)21(25)23-14-22-20/h2-10,13-14H,11-12H2,1H3,(H,22,23,25)

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PF-6260933

规格或纯度 :

≥98%

CAS号: 1811510-56-1 Compound CID : 118701008

分子式: C₁₆H₁₃ClN₄ 分子量: 296.75

IUPAC Name: 5-(6-aminopyridin-3-yl)-3-(4-chlorophenyl)pyridin-2-amine

SMILES: C1=CC(=CC=C1C2=C(N=CC(=C2)C3=CN=C(C=C3)N)N)Cl

InChIKey: KHPCIHZXOGHCLY-UHFFFAOYSA-N

InChI: 1S/C16H13ClN4/c17-13-4-1-10(2-5-13)14-7-12(9-21-16(14)19)11-3-6-15(18)20-8-11/h1-9H,(H2,18,20)(H2,19,21)

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NCB-0846

规格或纯度 :

≥99%

CAS号: 1792999-26-8

分子式: C₂₁H₂₁N₅O₂ 分子量: 375.42

IUPAC Name: 4-[2-(3H-benzimidazol-5-ylamino)quinazolin-8-yl]oxycyclohexan-1-ol

SMILES: C1CC(CCC1O)OC2=CC=CC3=CN=C(N=C32)NC4=CC5=C(C=C4)N=CN5

InChIKey: FYWRWBSYRGSWIQ-UHFFFAOYSA-N

InChI: 1S/C21H21N5O2/c27-15-5-7-16(8-6-15)28-19-3-1-2-13-11-22-21(26-20(13)19)25-14-4-9-17-18(10-14)24-12-23-17/h1-4,9-12,15-16,27H,5-8H2,(H,23,24)(H,22,25,26)

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DMX-5084

规格或纯度 :

10mM in DMSO

CAS号: 2306178-56-1

分子式: C₂₁H₁₉N₃O₃ 分子量: 361.39

IUPAC Name: 5-[4-(2-methoxyethoxy)phenyl]-7-phenyl-3H-pyrrolo[2,3-d]pyrimidin-4-one

SMILES: COCCOC1=CC=C(C=C1)C2=CN(C3=C2C(=O)NC=N3)C4=CC=CC=C4

InChIKey: FUSHFOGORKZNNQ-UHFFFAOYSA-N

InChI: 1S/C21H19N3O3/c1-26-11-12-27-17-9-7-15(8-10-17)18-13-24(16-5-3-2-4-6-16)20-19(18)21(25)23-14-22-20/h2-10,13-14H,11-12H2,1H3,(H,22,23,25)

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NG25

规格或纯度 :

Moligand™

10mM in DMSO

CAS号: 1315355-93-1

分子式: C₂₉H₃₀F₃N₅O₂ 分子量: 537.58

IUPAC Name: N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide

SMILES: CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)OC4=C5C=CNC5=NC=C4)C(F)(F)F

InChIKey: SMPGEBOIKULBCT-UHFFFAOYSA-N

InChI: 1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11,16-17H,3,12-15,18H2,1-2H3,(H,33,34)(H,35,38)

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PF-6260933

规格或纯度 :

10mM in DMSO

CAS号: 1811510-56-1 Compound CID : 118701008

分子式: C₁₆H₁₃ClN₄ 分子量: 296.75

IUPAC Name: 5-(6-aminopyridin-3-yl)-3-(4-chlorophenyl)pyridin-2-amine

SMILES: C1=CC(=CC=C1C2=C(N=CC(=C2)C3=CN=C(C=C3)N)N)Cl

InChIKey: KHPCIHZXOGHCLY-UHFFFAOYSA-N

InChI: 1S/C16H13ClN4/c17-13-4-1-10(2-5-13)14-7-12(9-21-16(14)19)11-3-6-15(18)20-8-11/h1-9H,(H2,18,20)(H2,19,21)

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HPK1-IN-34

CAS号: 2380300-99-0

分子式: C₂₅H₂₈N₄O₂S 分子量: 448.58

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HPK1-IN-7

规格或纯度 :

≥99%

CAS号: 2320462-65-3 Compound CID : 142587219

分子式: C₂₄H₂₂N₆O₄ 分子量: 458.5

IUPAC Name: 5-[[4-[[(1S)-2-hydroxy-1-phenylethyl]amino]-5-(1,3,4-oxadiazol-2-yl)pyrimidin-2-yl]amino]-3,3-dimethyl-2-benzofuran-1-one

SMILES: CC1(C2=C(C=CC(=C2)NC3=NC=C(C(=N3)NC(CO)C4=CC=CC=C4)C5=NN=CO5)C(=O)O1)C

InChIKey: RVSSNRBUPQUIEG-LJQANCHMSA-N

InChI: 1S/C24H22N6O4/c1-24(2)18-10-15(8-9-16(18)22(32)34-24)27-23-25-11-17(21-30-26-13-33-21)20(29-23)28-19(12-31)14-6-4-3-5-7-14/h3-11,13,19,31H,12H2,1-2H3,(H2,25,27,28,29)/t19-/m1/s1

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DB1113

规格或纯度 :

≥99%

CAS号: 2769753-53-7

分子式: C₅₉H₆₈F₃N₁₃O₆S 分子量: 1144.31

SMILES: O=C1N(C2=CC(NC(C3=CC(C(F)(F)F)=CC=C3)=O)=CC=C2C)CC4=CN=C(NC5=CN=C(N6CCN(CC6)CCCCC(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(N[C@H](C8=CC=C(C9=C(N=CS9)C)C=C8)C)=O)=O)=O)C=C5)N=C4N1C

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